AutismKB 2.0

Annotation Detail for SPRY2


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Basic Information Top
Gene Symbol:SPRY2 ( MGC23039,hSPRY2 )
Gene Full Name: sprouty homolog 2 (Drosophila)
Band: 13q31.1
Quick LinksEntrez ID:10253; OMIM: 602466; Uniprot ID:SPY2_HUMAN; ENSEMBL ID: ENSG00000136158; HGNC ID: 11270
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst1 / 6231916
fetus21 / 56401237
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult45 / 193912123
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma5 / 8282360
colorectal tumor5 / 11424643
esophageal tumor0 / 172900 
gastrointestinal tumor10 / 11936983
germ cell tumor3 / 26384511
glioma4 / 10688337
head and neck tumor1 / 1363027
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor3 / 9635931
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia4 / 9725041
normal86 / 336030725
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor4 / 12494932
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder1 / 2975733
blood0 / 1234780 
bone2 / 7165527
bone marrow0 / 488010 
brain31 / 110098928
cervix0 / 481710 
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue10 / 21572246
esophagus0 / 202090 
eye15 / 21105471
heart1 / 8962611
intestine13 / 23447255
kidney3 / 21177714
larynx1 / 2414541
liver3 / 20774314
lung9 / 33697426
lymph1 / 4427022
lymph node0 / 916100 
mammary gland3 / 15327119
mouth0 / 670520 
muscle5 / 10771546
nerve2 / 15768126
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta3 / 28082510
prostate1 / 1893455
salivary gland0 / 201550 
skin4 / 21057418
spleen0 / 539520 
stomach6 / 9661962
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204011_at
Cell line Expression level Expression bar
721_B_lymphoblasts14.85
Adipocyte14
AdrenalCortex22.4
Adrenalgland49.65
Amygdala134.35
Appendix44.7
AtrioventricularNode27.7
BDCA4+_DentriticCells7.4
Bonemarrow22.3
BronchialEpithelialCells18.35
CD105+_Endothelial6.3
CD14+_Monocytes9.25
CD19+_BCells(neg._sel.)6.55
CD33+_Myeloid13.85
CD34+13.35
CD4+_Tcells8.05
CD56+_NKCells13.1
CD71+_EarlyErythroid6
CD8+_Tcells5.95
CardiacMyocytes23.75
Caudatenucleus46.35
Cerebellum358.35
CerebellumPeduncles253.8
CiliaryGanglion13.9
CingulateCortex51.45
Colorectaladenocarcinoma14.15
DorsalRootGanglion20.5
FetalThyroid15.55
Fetalbrain106.3
Fetalliver13.35
Fetallung33.15
GlobusPallidus17.4
Heart72.35
Hypothalamus51.3
Kidney21.7
Leukemia_chronicMyelogenousK-56211.1
Leukemia_promyelocytic-HL-608.3
Leukemialymphoblastic(MOLT-4)9.2
Liver24
Lung109.25
Lymphnode10.35
Lymphoma_burkitts(Daudi)16.3
Lymphoma_burkitts(Raji)16.75
MedullaOblongata58.45
OccipitalLobe111.3
OlfactoryBulb39.95
Ovary9.7
Pancreas114.3
PancreaticIslet19.1
ParietalLobe38.25
Pituitary22.4
Placenta29.15
Pons43.75
PrefrontalCortex152.25
Prostate25.05
Salivarygland21.25
SkeletalMuscle34.45
Skin18.8
SmoothMuscle17.85
Spinalcord88.4
SubthalamicNucleus32.6
SuperiorCervicalGanglion23.15
TemporalLobe47.35
Testis9.95
TestisGermCell10.05
TestisIntersitial10.1
TestisLeydigCell15.35
TestisSeminiferousTubule9.9
Thalamus32.8
Thymus25.25
Thyroid32.75
Tongue20.4
Tonsil12.25
Trachea56.5
TrigeminalGanglion14.45
Uterus45.4
UterusCorpus13.55
WholeBlood10
Wholebrain216.75
colon127.45
pineal_day18.98
pineal_night17.12
retina149.575
small_intestine128.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15996_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.14 ± 0.64
Basal Forebrain3.8 ± 0.3
Basal Part of Pons3.79 ± 0.52
Cerebellar Cortex4.18 ± 0.3
Cerebellar Nuclei3.81 ± 0.71
Claustrum4.62 ± 0.75
Epithalamus3.89 ± 0.57
Frontal Lobe3.78 ± 0.55
Globus Pallidus3.99 ± 0.52
Hypothalamus3.74 ± 0.54
Insula3.86 ± 0.37
Limbic Lobe3.94 ± 0.61
Mesencephalon3.89 ± 0.59
Myelencephalon3.9 ± 0.56
Occipital Lobe3.97 ± 0.6
Parietal Lobe3.95 ± 0.57
Pontine Tegmentum3.95 ± 0.63
Striatum3.78 ± 0.62
Subthalamus3.73 ± 0.16
Temporal Lobe3.8 ± 0.5
Thalamus3.78 ± 0.58
White Matter3.83 ± 0.15
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Spry2CBCerebellum26.26
37.62
Spry2CTXCerebral cortex100
100
Spry2HIPHippocampal region31.46
48.6
Spry2HPFHippocampal formation34.87
44.18
Spry2HYHypothalamus7.64
7.07
Spry2LSXLateral septal complex16.45
15.07
Spry2MBMidbrain10.67
10.29
Spry2MYMedulla10.93
10.52
Spry2OLFOlfactory bulb59.12
57.66
Spry2PPons10.8
11.91
Spry2PALPallidum7.45
7.67
Spry2RHPRetrohippocampal region40.21
38.54
Spry2sAMYStriatum-like amygdalar nuclei10.35
9.52
Spry2STRStriatum100
99.49
Spry2STRdStriatum dorsal region100
100
Spry2STRvStriatum ventral region99.48
100
Spry2THThalamus14.36
14.99
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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