AutismKB 2.0

Annotation Detail for DENND4A


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Basic Information Top
Gene Symbol:DENND4A ( FLJ33949,IRLB,KIAA0476,MYCPBP )
Gene Full Name: DENN/MADD domain containing 4A
Band: 15q22.31
Quick LinksEntrez ID:10260; OMIM: 600382; Uniprot ID:MYCPP_HUMAN; ENSEMBL ID: ENSG00000174485; HGNC ID: 24321
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus15 / 56401226
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult23 / 193912111
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor3 / 3436687
chondrosarcoma1 / 8282312
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor2 / 2638457
glioma0 / 1068830 
head and neck tumor5 / 13630236
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma2 / 7175527
non-neoplasia7 / 9725071
normal73 / 336030721
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone3 / 7165541
bone marrow0 / 488010 
brain20 / 110098918
cervix3 / 4817162
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye7 / 21105433
heart1 / 8962611
intestine2 / 2344728
kidney2 / 2117779
larynx1 / 2414541
liver3 / 20774314
lung1 / 3369742
lymph2 / 4427045
lymph node17 / 91610185
mammary gland1 / 1532716
mouth4 / 6705259
muscle3 / 10771527
nerve2 / 15768126
ovary2 / 10205119
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate0 / 1893450 
salivary gland0 / 201550 
skin1 / 2105744
spleen2 / 5395237
stomach3 / 9661931
testis4 / 33044212
thymus1 / 8113112
thyroid0 / 474730 
tonsil1 / 1699958
trachea1 / 5241319
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 214787_at
Cell line Expression level Expression bar
721_B_lymphoblasts11.65
Adipocyte5.3
AdrenalCortex6.3
Adrenalgland4.7
Amygdala5.6
Appendix7.65
AtrioventricularNode4.8
BDCA4+_DentriticCells5.55
Bonemarrow5.8
BronchialEpithelialCells5.2
CD105+_Endothelial6
CD14+_Monocytes6.4
CD19+_BCells(neg._sel.)6.25
CD33+_Myeloid6.7
CD34+7
CD4+_Tcells5.8
CD56+_NKCells6.4
CD71+_EarlyErythroid7.55
CD8+_Tcells6.45
CardiacMyocytes7.95
Caudatenucleus4.9
Cerebellum4.4
CerebellumPeduncles6.55
CiliaryGanglion4.35
CingulateCortex5.75
Colorectaladenocarcinoma5.45
DorsalRootGanglion4.6
FetalThyroid5.35
Fetalbrain5.25
Fetalliver7.2
Fetallung4.25
GlobusPallidus4.2
Heart7.8
Hypothalamus5.7
Kidney4.75
Leukemia_chronicMyelogenousK-5624.9
Leukemia_promyelocytic-HL-604.85
Leukemialymphoblastic(MOLT-4)4.2
Liver7.85
Lung6
Lymphnode4.65
Lymphoma_burkitts(Daudi)7.2
Lymphoma_burkitts(Raji)8.15
MedullaOblongata4.95
OccipitalLobe4.85
OlfactoryBulb4.25
Ovary4
Pancreas4.5
PancreaticIslet5.9
ParietalLobe6
Pituitary6.4
Placenta5.45
Pons5.35
PrefrontalCortex6.9
Prostate6.3
Salivarygland4.55
SkeletalMuscle7.1
Skin5.3
SmoothMuscle6.2
Spinalcord5.85
SubthalamicNucleus5.25
SuperiorCervicalGanglion7.05
TemporalLobe5.35
Testis4.65
TestisGermCell4.45
TestisIntersitial4.7
TestisLeydigCell5.55
TestisSeminiferousTubule4.65
Thalamus5.65
Thymus4.15
Thyroid6.85
Tongue5.75
Tonsil5.35
Trachea4.5
TrigeminalGanglion6.05
Uterus4.45
UterusCorpus5.55
WholeBlood6.05
Wholebrain4.4
colon5.5
pineal_day11.78
pineal_night16.66
retina6.625
small_intestine5.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P384329
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.65 ± 0.24
Basal Forebrain6.68 ± 0.26
Basal Part of Pons6.24 ± 0.44
Cerebellar Cortex6.91 ± 0.28
Cerebellar Nuclei6.56 ± 0.28
Claustrum6.53 ± 0.62
Epithalamus6.68 ± 0.31
Frontal Lobe6.37 ± 0.46
Globus Pallidus6.03 ± 0.34
Hypothalamus6.71 ± 0.36
Insula6.38 ± 0.35
Limbic Lobe6.52 ± 0.49
Mesencephalon6.46 ± 0.52
Myelencephalon6.48 ± 0.46
Occipital Lobe6.84 ± 0.31
Parietal Lobe6.62 ± 0.4
Pontine Tegmentum6.53 ± 0.45
Striatum6.49 ± 0.46
Subthalamus6.47 ± 0.8
Temporal Lobe6.49 ± 0.39
Thalamus6.41 ± 0.33
White Matter6.6 ± 0.49
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
AI115600CBCerebellum1.37
2.34
AI115600CTXCerebral cortex2.57
2.19
AI115600HIPHippocampal region1.14
2.01
AI115600HPFHippocampal formation0.79
1.16
AI115600HYHypothalamus0.13
0.1
AI115600LSXLateral septal complex0.26
0
AI115600MBMidbrain1.59
2.16
AI115600MYMedulla0.61
0.91
AI115600OLFOlfactory bulb1.65
1.8
AI115600PPons0.49
0.55
AI115600PALPallidum0.81
0.82
AI115600RHPRetrohippocampal region0.43
0.4
AI115600sAMYStriatum-like amygdalar nuclei1.01
0.85
AI115600STRStriatum1.19
1.39
AI115600STRdStriatum dorsal region1.47
1.85
AI115600STRvStriatum ventral region0.43
0.31
AI115600THThalamus1.33
1.54
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00504077 22 1161 1182 TDVATGFDPLSLLVAETEQQQK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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