AutismKB 2.0

Annotation Detail for AKAP8


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Basic Information Top
Gene Symbol:AKAP8 ( AKAP95,DKFZp586B1222 )
Gene Full Name: A kinase (PRKA) anchor protein 8
Band: 19p13.12
Quick LinksEntrez ID:10270; OMIM: 604692; Uniprot ID:AKAP8_HUMAN; ENSEMBL ID: ENSG00000105127; HGNC ID: 378
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus2 / 5640123
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult14 / 19391217
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal17 / 33603075
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain0 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye1 / 2110544
heart2 / 8962622
intestine0 / 2344720 
kidney1 / 2117774
larynx1 / 2414541
liver0 / 2077430 
lung3 / 3369748
lymph0 / 442700 
lymph node1 / 9161010
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas2 / 2148129
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta3 / 28082510
prostate0 / 1893450 
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach2 / 9661920
testis4 / 33044212
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203847_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts69.75
Adipocyte48.05
AdrenalCortex54.35
Adrenalgland42.7
Amygdala55.45
Appendix64.6
AtrioventricularNode40.1
BDCA4+_DentriticCells83.55
Bonemarrow56.3
BronchialEpithelialCells53.4
CD105+_Endothelial55.25
CD14+_Monocytes57.75
CD19+_BCells(neg._sel.)70.45
CD33+_Myeloid70.75
CD34+72.95
CD4+_Tcells73.55
CD56+_NKCells65.85
CD71+_EarlyErythroid59.15
CD8+_Tcells70.1
CardiacMyocytes65.65
Caudatenucleus46.55
Cerebellum43.45
CerebellumPeduncles59.95
CiliaryGanglion36.1
CingulateCortex52.95
Colorectaladenocarcinoma57.2
DorsalRootGanglion39.5
FetalThyroid50.15
Fetalbrain56.8
Fetalliver44.7
Fetallung45.6
GlobusPallidus38.25
Heart64.45
Hypothalamus55
Kidney42.25
Leukemia_chronicMyelogenousK-56250.05
Leukemia_promyelocytic-HL-6061.05
Leukemialymphoblastic(MOLT-4)61.8
Liver67.3
Lung59.95
Lymphnode50.9
Lymphoma_burkitts(Daudi)67.85
Lymphoma_burkitts(Raji)84.25
MedullaOblongata49.15
OccipitalLobe45.55
OlfactoryBulb38.95
Ovary42.7
Pancreas40.8
PancreaticIslet56.7
ParietalLobe55.2
Pituitary62.95
Placenta60.9
Pons52.75
PrefrontalCortex64
Prostate63.55
Salivarygland41.05
SkeletalMuscle65.65
Skin39.55
SmoothMuscle57.3
Spinalcord48.15
SubthalamicNucleus48.55
SuperiorCervicalGanglion58.75
TemporalLobe50.7
Testis45.35
TestisGermCell46.4
TestisIntersitial48.75
TestisLeydigCell54.7
TestisSeminiferousTubule52.55
Thalamus52.6
Thymus44.45
Thyroid67.7
Tongue51.85
Tonsil63.2
Trachea45.05
TrigeminalGanglion51.7
Uterus45.15
UterusCorpus58.6
WholeBlood52.15
Wholebrain45.55
colon49.55
pineal_day61.34
pineal_night62.1
retina65.625
small_intestine39.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10339_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.14 ± 0.64
Basal Forebrain5.03 ± 0.18
Basal Part of Pons4.63 ± 0.36
Cerebellar Cortex4.92 ± 0.38
Cerebellar Nuclei4.8 ± 0.31
Claustrum5.33 ± 0.61
Epithalamus4.9 ± 0.33
Frontal Lobe4.7 ± 0.5
Globus Pallidus4.58 ± 0.63
Hypothalamus4.53 ± 0.38
Insula4.75 ± 0.39
Limbic Lobe4.87 ± 0.5
Mesencephalon4.72 ± 0.6
Myelencephalon4.72 ± 0.57
Occipital Lobe4.98 ± 0.45
Parietal Lobe4.77 ± 0.52
Pontine Tegmentum4.9 ± 0.58
Striatum4.97 ± 0.53
Subthalamus4.08 ± 0.15
Temporal Lobe4.73 ± 0.45
Thalamus4.61 ± 0.55
White Matter5.48 ± 0.68
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Akap8CBCerebellum9.61
9.34
Akap8CTXCerebral cortex5.06
2.73
Akap8HIPHippocampal region18.09
8.69
Akap8HPFHippocampal formation13.09
6.03
Akap8HYHypothalamus8.31
3.94
Akap8LSXLateral septal complex1.32
1.33
Akap8MBMidbrain5.25
3.7
Akap8MYMedulla9.71
8.15
Akap8OLFOlfactory bulb12.29
7.88
Akap8PPons11.46
8.7
Akap8PALPallidum3.92
2.32
Akap8RHPRetrohippocampal region3.87
2.04
Akap8sAMYStriatum-like amygdalar nuclei6.5
3.06
Akap8STRStriatum2.06
1.08
Akap8STRdStriatum dorsal region1.43
0.79
Akap8STRvStriatum ventral region6.64
3.82
Akap8THThalamus5.51
3.19
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00009291 33 63 95 ANDGGLAAGAPAMHMASYGPEPCTDNSDSLIAK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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