AutismKB 2.0

Annotation Detail for UBE4B


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Basic Information Top
Gene Symbol:UBE4B ( E4,HDNB1,KIAA0684,UBOX3,UFD2,UFD2A )
Gene Full Name: ubiquitination factor E4B (UFD2 homolog, yeast)
Band: 1p36.22
Quick LinksEntrez ID:10277; OMIM: 613565; Uniprot ID:UBE4B_HUMAN; ENSEMBL ID: ENSG00000130939; HGNC ID: 12500
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst7 / 62319112
fetus45 / 56401279
neonate2 / 3109764
infant0 / 236200 
juvenile4 / 5555671
adult159 / 193912181
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor5 / 9417853
cervical tumor4 / 34366116
chondrosarcoma7 / 8282384
colorectal tumor4 / 11424635
esophageal tumor2 / 17290115
gastrointestinal tumor3 / 11936925
germ cell tumor13 / 26384549
glioma7 / 10688365
head and neck tumor11 / 13630280
kidney tumor2 / 6895929
leukemia4 / 9584241
liver tumor11 / 96359114
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia11 / 97250113
normal241 / 336030771
ovarian tumor15 / 76682195
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer7 / 10268068
retinoblastoma5 / 46356107
skin tumor5 / 12494940
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites2 / 4001549
bladder1 / 2975733
blood1 / 1234788
bone6 / 7165583
bone marrow1 / 4880120
brain67 / 110098960
cervix4 / 4817183
connective tissue10 / 14925566
ear2 / 16212123
embryonic tissue21 / 21572297
esophagus2 / 2020998
eye22 / 211054104
heart12 / 89626133
intestine11 / 23447246
kidney10 / 21177747
larynx3 / 24145124
liver15 / 20774372
lung41 / 336974121
lymph0 / 442700 
lymph node24 / 91610261
mammary gland9 / 15327158
mouth5 / 6705274
muscle2 / 10771518
nerve1 / 1576863
ovary16 / 102051156
pancreas15 / 21481269
parathyroid23 / 205391119
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta24 / 28082585
prostate12 / 18934563
salivary gland0 / 201550 
skin18 / 21057485
spleen2 / 5395237
stomach9 / 9661993
testis16 / 33044248
thymus3 / 8113136
thyroid3 / 4747363
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus16 / 23287868
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210685_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts23.35
Adipocyte13.95
AdrenalCortex21.2
Adrenalgland13.05
Amygdala13.25
Appendix16.75
AtrioventricularNode18.25
BDCA4+_DentriticCells15.55
Bonemarrow17.1
BronchialEpithelialCells13.2
CD105+_Endothelial29.35
CD14+_Monocytes16.2
CD19+_BCells(neg._sel.)14.6
CD33+_Myeloid19.85
CD34+26.65
CD4+_Tcells14.1
CD56+_NKCells16.6
CD71+_EarlyErythroid31.15
CD8+_Tcells13.2
CardiacMyocytes30.5
Caudatenucleus13.15
Cerebellum12.3
CerebellumPeduncles19.05
CiliaryGanglion19.15
CingulateCortex15.9
Colorectaladenocarcinoma19.25
DorsalRootGanglion14.65
FetalThyroid14.6
Fetalbrain14.9
Fetalliver11.95
Fetallung10
GlobusPallidus14.35
Heart30.2
Hypothalamus16.85
Kidney13.8
Leukemia_chronicMyelogenousK-56212.7
Leukemia_promyelocytic-HL-6013.05
Leukemialymphoblastic(MOLT-4)10.15
Liver21.9
Lung15.1
Lymphnode11.15
Lymphoma_burkitts(Daudi)20.45
Lymphoma_burkitts(Raji)23.95
MedullaOblongata12.85
OccipitalLobe14.6
OlfactoryBulb10.15
Ovary11.85
Pancreas12
PancreaticIslet14.95
ParietalLobe17.75
Pituitary16.2
Placenta12.35
Pons14.4
PrefrontalCortex20.05
Prostate15.35
Salivarygland12.3
SkeletalMuscle26.55
Skin15.9
SmoothMuscle16.65
Spinalcord14.95
SubthalamicNucleus14.9
SuperiorCervicalGanglion27.8
TemporalLobe13.6
Testis11.8
TestisGermCell10.15
TestisIntersitial12.95
TestisLeydigCell15.4
TestisSeminiferousTubule12
Thalamus15.75
Thymus10.2
Thyroid32.55
Tongue18.8
Tonsil14.15
Trachea11
TrigeminalGanglion22.45
Uterus17.6
UterusCorpus13.95
WholeBlood15.45
Wholebrain14.65
colon13.2
pineal_day19.46
pineal_night27.06
retina20.525
small_intestine15.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_6119_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.47 ± 0.51
Basal Forebrain5.41 ± 0.36
Basal Part of Pons5.32 ± 0.36
Cerebellar Cortex5.22 ± 0.39
Cerebellar Nuclei5.45 ± 0.35
Claustrum5.79 ± 0.52
Epithalamus4.76 ± 0.4
Frontal Lobe5.14 ± 0.43
Globus Pallidus5.63 ± 0.24
Hypothalamus4.79 ± 0.41
Insula4.98 ± 0.28
Limbic Lobe5.47 ± 0.5
Mesencephalon5.25 ± 0.49
Myelencephalon5.27 ± 0.4
Occipital Lobe5.71 ± 0.51
Parietal Lobe5.33 ± 0.37
Pontine Tegmentum5.36 ± 0.43
Striatum5.46 ± 0.5
Subthalamus5 ± 0.12
Temporal Lobe5.18 ± 0.37
Thalamus5.35 ± 0.42
White Matter6.08 ± 0.51
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ube4bCBCerebellum40.41
54.29
Ube4bCTXCerebral cortex100
89.54
Ube4bHIPHippocampal region54.78
87.41
Ube4bHPFHippocampal formation76.2
89.24
Ube4bHYHypothalamus51.13
33.63
Ube4bLSXLateral septal complex65.05
38.31
Ube4bMBMidbrain67.11
58.59
Ube4bMYMedulla69.87
80.81
Ube4bOLFOlfactory bulb79.6
64.34
Ube4bPPons65.42
66.45
Ube4bPALPallidum56.62
42.26
Ube4bRHPRetrohippocampal region95.37
86.68
Ube4bsAMYStriatum-like amygdalar nuclei83.58
54.12
Ube4bSTRStriatum100
81.36
Ube4bSTRdStriatum dorsal region100
89.39
Ube4bSTRvStriatum ventral region100
86.18
Ube4bTHThalamus88.35
74.31
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00067877 17 844 860 FYTDVEHTGATSEFYDK Peptide Atlas
UBE4B_HUMAN_1 10 1 10 MEELSADEIR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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