AutismKB 2.0

Annotation Detail for DNAJA2


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Basic Information Top
Gene Symbol:DNAJA2 ( CPR3,DJ3,DJA2,DNAJ,DNJ3,HIRIP4,PRO3015,RDJ2 )
Gene Full Name: DnaJ (Hsp40) homolog, subfamily A, member 2
Band: 16q11.2
Quick LinksEntrez ID:10294; OMIM: 611322; Uniprot ID:DNJA2_HUMAN; ENSEMBL ID: ENSG00000069345; HGNC ID: 14884
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst5 / 6231980
fetus36 / 56401263
neonate2 / 3109764
infant2 / 2362084
juvenile5 / 5555689
adult181 / 193912193
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor8 / 9417884
cervical tumor0 / 343660 
chondrosarcoma5 / 8282360
colorectal tumor23 / 114246201
esophageal tumor2 / 17290115
gastrointestinal tumor6 / 11936950
germ cell tumor32 / 263845121
glioma2 / 10688318
head and neck tumor19 / 136302139
kidney tumor2 / 6895929
leukemia6 / 9584262
liver tumor14 / 96359145
lung tumor3 / 10312729
lymphoma3 / 7175541
non-neoplasia2 / 9725020
normal250 / 336030774
ovarian tumor10 / 76682130
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer9 / 10268087
retinoblastoma2 / 4635643
skin tumor9 / 12494972
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor17 / 90257188
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites5 / 40015124
bladder2 / 2975767
blood12 / 12347897
bone14 / 71655195
bone marrow1 / 4880120
brain72 / 110098965
cervix1 / 4817120
connective tissue4 / 14925526
ear1 / 1621261
embryonic tissue11 / 21572250
esophagus2 / 2020998
eye12 / 21105456
heart4 / 8962644
intestine30 / 234472127
kidney5 / 21177723
larynx5 / 24145207
liver21 / 207743101
lung18 / 33697453
lymph1 / 4427022
lymph node4 / 9161043
mammary gland14 / 15327191
mouth6 / 6705289
muscle13 / 107715120
nerve0 / 157680 
ovary10 / 10205197
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland2 / 16585120
placenta29 / 280825103
prostate13 / 18934568
salivary gland1 / 2015549
skin13 / 21057461
spleen5 / 5395292
stomach4 / 9661941
testis42 / 330442127
thymus4 / 8113149
thyroid8 / 47473168
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus26 / 232878111
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209157_at
Cell line Expression level Expression bar
721_B_lymphoblasts67.2
Adipocyte12.8
AdrenalCortex10.8
Adrenalgland9.85
Amygdala33.4
Appendix12.1
AtrioventricularNode7.75
BDCA4+_DentriticCells23.15
Bonemarrow8.65
BronchialEpithelialCells67.3
CD105+_Endothelial12.9
CD14+_Monocytes24.1
CD19+_BCells(neg._sel.)27.15
CD33+_Myeloid36.2
CD34+24
CD4+_Tcells35.75
CD56+_NKCells57.4
CD71+_EarlyErythroid20.65
CD8+_Tcells39.05
CardiacMyocytes15.8
Caudatenucleus10.95
Cerebellum10.5
CerebellumPeduncles14
CiliaryGanglion6.25
CingulateCortex14.85
Colorectaladenocarcinoma17.15
DorsalRootGanglion6.15
FetalThyroid9.6
Fetalbrain11.2
Fetalliver10.35
Fetallung8.5
GlobusPallidus13.5
Heart13.75
Hypothalamus23.55
Kidney9.8
Leukemia_chronicMyelogenousK-5629.9
Leukemia_promyelocytic-HL-6026.15
Leukemialymphoblastic(MOLT-4)11.75
Liver13.8
Lung12.45
Lymphnode10.15
Lymphoma_burkitts(Daudi)15
Lymphoma_burkitts(Raji)22
MedullaOblongata10.65
OccipitalLobe16.55
OlfactoryBulb8.85
Ovary6.45
Pancreas9.8
PancreaticIslet20.5
ParietalLobe13.7
Pituitary11.3
Placenta23.5
Pons10.6
PrefrontalCortex31.85
Prostate15.45
Salivarygland10.85
SkeletalMuscle12.75
Skin7.3
SmoothMuscle21.05
Spinalcord11.7
SubthalamicNucleus11.4
SuperiorCervicalGanglion8.75
TemporalLobe11.9
Testis19.35
TestisGermCell22.05
TestisIntersitial11.25
TestisLeydigCell12.5
TestisSeminiferousTubule16.2
Thalamus17.3
Thymus10.4
Thyroid16.4
Tongue9.9
Tonsil10.1
Trachea10.55
TrigeminalGanglion10.3
Uterus20.5
UterusCorpus10
WholeBlood35.9
Wholebrain58.7
colon59.85
pineal_day51.32
pineal_night50.18
retina24.425
small_intestine68.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9029_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.12 ± 0.26
Basal Forebrain7.04 ± 0.22
Basal Part of Pons7.52 ± 0.18
Cerebellar Cortex7.01 ± 0.22
Cerebellar Nuclei7.28 ± 0.33
Claustrum7.06 ± 0.51
Epithalamus7.24 ± 0.15
Frontal Lobe7.29 ± 0.3
Globus Pallidus6.6 ± 0.31
Hypothalamus7.16 ± 0.47
Insula7.21 ± 0.24
Limbic Lobe7.15 ± 0.38
Mesencephalon7.15 ± 0.36
Myelencephalon7.15 ± 0.34
Occipital Lobe7.06 ± 0.43
Parietal Lobe7.24 ± 0.34
Pontine Tegmentum7.1 ± 0.25
Striatum7.17 ± 0.37
Subthalamus7.4 ± 0.24
Temporal Lobe7.25 ± 0.29
Thalamus7.21 ± 0.23
White Matter6.67 ± 0.11
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dnaja2CBCerebellum29.82
58.39
Dnaja2CTXCerebral cortex100
100
Dnaja2HIPHippocampal region86.57
100
Dnaja2HPFHippocampal formation91.38
100
Dnaja2HYHypothalamus56.64
52.68
Dnaja2LSXLateral septal complex77.82
71.26
Dnaja2MBMidbrain69.7
76.04
Dnaja2MYMedulla60.37
82.53
Dnaja2OLFOlfactory bulb60.92
62.39
Dnaja2PPons58.39
77.2
Dnaja2PALPallidum58.24
64.19
Dnaja2RHPRetrohippocampal region100
100
Dnaja2sAMYStriatum-like amygdalar nuclei53.73
48.77
Dnaja2STRStriatum63.01
53.09
Dnaja2STRdStriatum dorsal region68.14
57.65
Dnaja2STRvStriatum ventral region49.06
38
Dnaja2THThalamus77.28
83.93
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DNJA2_HUMAN_2 28 2 29 ANVADTKLYDILGVPPGASENELKKAYR PRIDE
DNJA2_HUMAN_230 32 230 261 ITFTGEADQAPGVEPGDIVLLLQEKEHEVFQR PRIDE
DNJA2_HUMAN_272 15 272 286 IGLVEALCGFQFTFK PRIDE
DNJA2_HUMAN_293 18 293 310 QIVVKYPPGKVIEPGCVR PRIDE
PAp00003809 15 273 287 IGLVEALCGFQFTFK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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