AutismKB 2.0

Annotation Detail for IKZF1


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Basic Information Top
Gene Symbol:IKZF1 ( Hs.54452,IK1,IKAROS,LYF1,PRO0758,ZNFN1A1,hIk-1 )
Gene Full Name: IKAROS family zinc finger 1 (Ikaros)
Band: 7p12.2
Quick LinksEntrez ID:10320; OMIM: 603023; Uniprot ID:IKZF1_HUMAN; ENSEMBL ID: ENSG00000185811; HGNC ID: 13176
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus24 / 56401242
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult31 / 193912115
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus4 / 5640127
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult3 / 19391211
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor16 / 26384560
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia11 / 95842114
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma16 / 71755222
non-neoplasia0 / 972500 
normal116 / 336030734
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma3 / 7175541
non-neoplasia0 / 972500 
normal19 / 33603075
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood15 / 123478121
bone1 / 7165513
bone marrow6 / 48801122
brain2 / 11009891
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart1 / 8962611
intestine2 / 2344728
kidney0 / 2117770 
larynx0 / 241450 
liver5 / 20774324
lung3 / 3369748
lymph9 / 44270203
lymph node37 / 91610403
mammary gland3 / 15327119
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid1 / 2053948
pharynx6 / 41328145
pituitary gland0 / 165850 
placenta1 / 2808253
prostate4 / 18934521
salivary gland2 / 2015599
skin0 / 2105740 
spleen11 / 53952203
stomach3 / 9661931
testis3 / 3304429
thymus10 / 81131123
thyroid1 / 4747321
tonsil4 / 16999235
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular1 / 5178019
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow2 / 4880140
brain0 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye1 / 2110544
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung1 / 3369742
lymph2 / 4427045
lymph node4 / 9161043
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen5 / 5395292
stomach1 / 9661910
testis3 / 3304429
thymus4 / 8113149
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205039_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts231.45
Adipocyte102.3
AdrenalCortex121.25
Adrenalgland100.8
Amygdala106.55
Appendix106.7
AtrioventricularNode83.85
BDCA4+_DentriticCells696.2
Bonemarrow263.7
BronchialEpithelialCells100.85
CD105+_Endothelial469.2
CD14+_Monocytes160.4
CD19+_BCells(neg._sel.)1071.15
CD33+_Myeloid628.85
CD34+550.15
CD4+_Tcells788.2
CD56+_NKCells1587.55
CD71+_EarlyErythroid610.6
CD8+_Tcells694.9
CardiacMyocytes131.4
Caudatenucleus95.45
Cerebellum84.85
CerebellumPeduncles159.8
CiliaryGanglion62.8
CingulateCortex106.8
Colorectaladenocarcinoma92.5
DorsalRootGanglion79.8
FetalThyroid108.8
Fetalbrain106.7
Fetalliver117.95
Fetallung88.35
GlobusPallidus76.55
Heart140.2
Hypothalamus107.8
Kidney87.05
Leukemia_chronicMyelogenousK-562101.2
Leukemia_promyelocytic-HL-60106.45
Leukemialymphoblastic(MOLT-4)346.95
Liver136.3
Lung113.25
Lymphnode164.35
Lymphoma_burkitts(Daudi)168.1
Lymphoma_burkitts(Raji)163.25
MedullaOblongata93.65
OccipitalLobe96.6
OlfactoryBulb74.2
Ovary76.65
Pancreas86.2
PancreaticIslet109.95
ParietalLobe126.75
Pituitary134.4
Placenta104.55
Pons134.4
PrefrontalCortex107
Prostate121.6
Salivarygland97.4
SkeletalMuscle127.25
Skin73.9
SmoothMuscle100.45
Spinalcord110.4
SubthalamicNucleus95.45
SuperiorCervicalGanglion120.75
TemporalLobe107.55
Testis88.6
TestisGermCell84.25
TestisIntersitial117.4
TestisLeydigCell103.35
TestisSeminiferousTubule105
Thalamus106.3
Thymus408.6
Thyroid127.85
Tongue104.7
Tonsil267.9
Trachea94.25
TrigeminalGanglion112.55
Uterus75.1
UterusCorpus121.25
WholeBlood337.75
Wholebrain85.2
colon103.65
pineal_day50.98
pineal_night41.88
retina103.6
small_intestine100
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P190631
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.52 ± 0.99
Basal Forebrain2.3 ± 0.38
Basal Part of Pons2.53 ± 0.66
Cerebellar Cortex1.81 ± 0.54
Cerebellar Nuclei2.48 ± 0.68
Claustrum2.97 ± 1
Epithalamus2.29 ± 0.79
Frontal Lobe1.92 ± 0.62
Globus Pallidus3.24 ± 0.76
Hypothalamus2.17 ± 0.82
Insula1.92 ± 0.67
Limbic Lobe1.97 ± 0.62
Mesencephalon2.22 ± 0.6
Myelencephalon2.12 ± 0.63
Occipital Lobe2.05 ± 0.55
Parietal Lobe2.09 ± 0.78
Pontine Tegmentum1.96 ± 0.79
Striatum2.34 ± 0.59
Subthalamus2.23 ± 0.74
Temporal Lobe2.07 ± 0.74
Thalamus2.11 ± 0.67
White Matter3.27 ± 0.84
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ikzf1CBCerebellum3.44
4.08
Ikzf1CTXCerebral cortex2.9
2.28
Ikzf1HIPHippocampal region6.44
4.21
Ikzf1HPFHippocampal formation5.79
3.95
Ikzf1HYHypothalamus1.77
1.07
Ikzf1LSXLateral septal complex0.92
0.59
Ikzf1MBMidbrain1.75
1.46
Ikzf1MYMedulla5.47
6.14
Ikzf1OLFOlfactory bulb7.76
5.85
Ikzf1PPons5.37
3.96
Ikzf1PALPallidum1.67
1.09
Ikzf1RHPRetrohippocampal region4.39
3.35
Ikzf1sAMYStriatum-like amygdalar nuclei2.44
1.67
Ikzf1STRStriatum1.93
1.16
Ikzf1STRdStriatum dorsal region1.78
1.08
Ikzf1STRvStriatum ventral region2.89
1.57
Ikzf1THThalamus2.44
1.48
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00009501 9 175 183 CHLCNYACR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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