AutismKB 2.0

Annotation Detail for TUBA1B


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Basic Information Top
Gene Symbol:TUBA1B ( K-ALPHA-1 )
Gene Full Name: tubulin, alpha 1b
Band: 12q13.12
Quick LinksEntrez ID:10376; OMIM: 602530; Uniprot ID:TBA1B_HUMAN; ENSEMBL ID: ENSG00000123416; HGNC ID: 18809
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body203 / 707612868
blastocyst194 / 623193113
fetus881 / 5640121562
neonate46 / 310971479
infant945 / 2362040008
juvenile532 / 555569575
adult3340 / 19391211722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor30 / 127942344
bladder carcinoma12 / 17475686
breast (mammary gland) tumor136 / 941781444
cervical tumor283 / 343668234
chondrosarcoma103 / 828231243
colorectal tumor406 / 1142463553
esophageal tumor20 / 172901156
gastrointestinal tumor437 / 1193693660
germ cell tumor1140 / 2638454320
glioma189 / 1068831768
head and neck tumor97 / 136302711
kidney tumor319 / 689594625
leukemia206 / 958422149
liver tumor540 / 963595604
lung tumor973 / 1031279434
lymphoma430 / 717555992
non-neoplasia689 / 972507084
normal6182 / 33603071839
ovarian tumor170 / 766822216
pancreatic tumor248 / 1046162370
primitive neuroectodermal tumor of the CNS2466 / 12568019621
prostate cancer236 / 1026802298
retinoblastoma498 / 4635610742
skin tumor472 / 1249493777
soft tissue/muscle tissue tumor679 / 1251915423
uterine tumor153 / 902571695
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue14 / 131061068
adrenal gland56 / 331971686
ascites245 / 400156122
bladder20 / 29757672
blood253 / 1234782048
bone122 / 716551702
bone marrow92 / 488011885
brain5251 / 11009894769
cervix323 / 481716705
connective tissue196 / 1492551313
ear12 / 16212740
embryonic tissue766 / 2157223550
esophagus41 / 202092028
eye683 / 2110543236
heart160 / 896261785
intestine625 / 2344722665
kidney374 / 2117771766
larynx9 / 24145372
liver679 / 2077433268
lung1285 / 3369743813
lymph321 / 442707250
lymph node130 / 916101419
mammary gland188 / 1532711226
mouth16 / 67052238
muscle361 / 1077153351
nerve32 / 157682029
ovary293 / 1020512871
pancreas330 / 2148121536
parathyroid6 / 20539292
pharynx66 / 413281596
pituitary gland11 / 16585663
placenta598 / 2808252129
prostate252 / 1893451330
salivary gland71 / 201553522
skin526 / 2105742497
spleen59 / 539521093
stomach164 / 966191697
testis876 / 3304422650
thymus146 / 811311799
thyroid6 / 47473126
tonsil73 / 169994294
trachea2 / 5241338
umbilical cord31 / 136802266
uterus549 / 2328782357
vascular44 / 51780849
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212639_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts9635.5
Adipocyte2466.9
AdrenalCortex1245.05
Adrenalgland1257.35
Amygdala12444.7
Appendix1263.95
AtrioventricularNode768.7
BDCA4+_DentriticCells3379.05
Bonemarrow3496.3
BronchialEpithelialCells5242
CD105+_Endothelial8106.5
CD14+_Monocytes2909.35
CD19+_BCells(neg._sel.)1440.3
CD33+_Myeloid5167
CD34+9117.5
CD4+_Tcells1486.55
CD56+_NKCells2499.55
CD71+_EarlyErythroid9080.5
CD8+_Tcells1189.1
CardiacMyocytes10254.85
Caudatenucleus6139.25
Cerebellum7015
CerebellumPeduncles10232.15
CiliaryGanglion2388.75
CingulateCortex8959.05
Colorectaladenocarcinoma8165.8
DorsalRootGanglion5091.25
FetalThyroid1772.5
Fetalbrain19748.25
Fetalliver2826.4
Fetallung3237.8
GlobusPallidus6953.8
Heart3325.4
Hypothalamus14495.95
Kidney549.75
Leukemia_chronicMyelogenousK-5625642.05
Leukemia_promyelocytic-HL-605596.65
Leukemialymphoblastic(MOLT-4)7725.05
Liver1245.3
Lung3196.3
Lymphnode1381.2
Lymphoma_burkitts(Daudi)6704.7
Lymphoma_burkitts(Raji)3413.5
MedullaOblongata10100.25
OccipitalLobe11831.8
OlfactoryBulb5614.05
Ovary1031.8
Pancreas990.75
PancreaticIslet2522.7
ParietalLobe12434.05
Pituitary2358.25
Placenta3349.75
Pons7887.45
PrefrontalCortex16156.05
Prostate1618.95
Salivarygland740.45
SkeletalMuscle703.2
Skin709.25
SmoothMuscle8785.35
Spinalcord14702.35
SubthalamicNucleus8743.35
SuperiorCervicalGanglion1229.95
TemporalLobe11486.8
Testis3125.85
TestisGermCell3977.85
TestisIntersitial2700.55
TestisLeydigCell1991.65
TestisSeminiferousTubule2115.3
Thalamus13259.8
Thymus4842.35
Thyroid1380.45
Tongue1655.7
Tonsil3342.05
Trachea1121.55
TrigeminalGanglion3456.55
Uterus2089.65
UterusCorpus4786.45
WholeBlood3555.5
Wholebrain12475.55
colon2281.8
pineal_day13442.62
pineal_night11661.52
retina8384.65
small_intestine2782.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P119998
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.54 ± 0.59
Basal Forebrain6.66 ± 0.28
Basal Part of Pons7.43 ± 0.29
Cerebellar Cortex6.77 ± 0.43
Cerebellar Nuclei6.87 ± 0.25
Claustrum6.86 ± 0.49
Epithalamus6.65 ± 0.36
Frontal Lobe7.06 ± 0.48
Globus Pallidus6.53 ± 0.49
Hypothalamus7.17 ± 0.42
Insula7.07 ± 0.37
Limbic Lobe6.97 ± 0.51
Mesencephalon6.81 ± 0.56
Myelencephalon6.86 ± 0.58
Occipital Lobe6.59 ± 0.5
Parietal Lobe6.81 ± 0.53
Pontine Tegmentum6.81 ± 0.51
Striatum6.05 ± 0.61
Subthalamus6.95 ± 0.46
Temporal Lobe7.11 ± 0.44
Thalamus7.01 ± 0.51
White Matter7.21 ± 0.7
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000326 20 403 422 AFVHWYVGEGMEEGEFSEAR Peptide Atlas
TBA1A_HUMAN_105 16 105 120 GHYTIGKEIIDLVLDR PRIDE
TBA1A_HUMAN_105 18 105 122 GHYTIGKEIIDLVLDRIR PRIDE
TBA1A_HUMAN_112 9 112 120 EIIDLVLDR PRIDE
TBA1A_HUMAN_123 33 123 155 KLADQCTGLQGFLVFHSFGGGTGSGFTSLLMER PRIDE
TBA1A_HUMAN_124 32 124 155 LADQCTGLQGFLVFHSFGGGTGSGFTSLLMER PRIDE
TBA1A_HUMAN_214 15 214 228 RNLDIERPTYTNLNR PRIDE
TBA1A_HUMAN_215 14 215 228 NLDIERPTYTNLNR PRIDE
TBA1A_HUMAN_229 14 229 242 LIGQIVSSITASLR PRIDE
TBA1A_HUMAN_243 21 243 263 FDGALNVDLTEFQTNLVPYPR PRIDE
TBA1A_HUMAN_264 16 264 279 IHFPLATYAPVISAEK PRIDE
TBA1A_HUMAN_280 24 280 303 AYHEQLSVAEITNACFEPANQMVK PRIDE
TBA1A_HUMAN_311 9 311 319 YMACCLLYR PRIDE
TBA1A_HUMAN_326 10 326 335 DVNAAIATIK PRIDE
TBA1A_HUMAN_338 14 338 351 RTIQFVDWCPTGFK PRIDE
TBA1A_HUMAN_339 13 339 351 TIQFVDWCPTGFK PRIDE
TBA1A_HUMAN_352 18 352 369 VGINYQPPTVVPGGDLAK PRIDE
TBA1A_HUMAN_373 17 373 389 AVCMLSNTTAIAEAWAR PRIDE
TBA1A_HUMAN_390 11 390 400 LDHKFDLMYAK PRIDE
TBA1A_HUMAN_390 12 390 401 LDHKFDLMYAKR PRIDE
TBA1A_HUMAN_40 20 40 59 TIGGGDDSFNTFFSETGAGK PRIDE
TBA1A_HUMAN_402 20 402 421 AFVHWYVGEGMEEGEFSEAR PRIDE
TBA1A_HUMAN_64 15 64 78 AVFVDLEPTVIDEVR PRIDE
TBA1A_HUMAN_66 14 66 79 VFVDLEPTVIDEVR PRIDE
TBA1A_HUMAN_84 12 84 95 QLFHPEQLITGK PRIDE
TBA1A_HUMAN_84 21 84 104 QLFHPEQLITGKEDAANNYAR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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