AutismKB 2.0

Annotation Detail for IRF9


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Basic Information Top
Gene Symbol:IRF9 ( IRF-9,ISGF3,ISGF3G,p48 )
Gene Full Name: interferon regulatory factor 9
Band: 14q12
Quick LinksEntrez ID:10379; OMIM: 147574; Uniprot ID:IRF9_HUMAN; ENSEMBL ID: ENSG00000213928; HGNC ID: 6131
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst3 / 6231948
fetus9 / 56401215
neonate0 / 310970 
infant0 / 236200 
juvenile3 / 5555653
adult149 / 193912176
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor2 / 3436658
chondrosarcoma7 / 8282384
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor19 / 119369159
germ cell tumor0 / 2638450 
glioma8 / 10688374
head and neck tumor6 / 13630244
kidney tumor0 / 689590 
leukemia5 / 9584252
liver tumor1 / 9635910
lung tumor3 / 10312729
lymphoma1 / 7175513
non-neoplasia6 / 9725061
normal172 / 336030751
ovarian tumor7 / 7668291
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor4 / 12494932
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland4 / 33197120
ascites3 / 4001574
bladder1 / 2975733
blood10 / 12347880
bone3 / 7165541
bone marrow0 / 488010 
brain44 / 110098939
cervix2 / 4817141
connective tissue7 / 14925546
ear1 / 1621261
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye6 / 21105428
heart1 / 8962611
intestine8 / 23447234
kidney4 / 21177718
larynx0 / 241450 
liver2 / 2077439
lung9 / 33697426
lymph0 / 442700 
lymph node5 / 9161054
mammary gland7 / 15327145
mouth2 / 6705229
muscle2 / 10771518
nerve1 / 1576863
ovary10 / 10205197
pancreas9 / 21481241
parathyroid3 / 20539146
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta37 / 280825131
prostate3 / 18934515
salivary gland2 / 2015599
skin6 / 21057428
spleen4 / 5395274
stomach32 / 96619331
testis6 / 33044218
thymus20 / 81131246
thyroid2 / 4747342
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus10 / 23287842
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203882_at
Cell line Expression level Expression bar
721_B_lymphoblasts337.45
Adipocyte45.4
AdrenalCortex50.45
Adrenalgland152.05
Amygdala87.75
Appendix100
AtrioventricularNode31.05
BDCA4+_DentriticCells702.05
Bonemarrow145.25
BronchialEpithelialCells56.3
CD105+_Endothelial52.55
CD14+_Monocytes421.7
CD19+_BCells(neg._sel.)337.8
CD33+_Myeloid302.45
CD34+86.1
CD4+_Tcells861.4
CD56+_NKCells514.95
CD71+_EarlyErythroid341.9
CD8+_Tcells822
CardiacMyocytes62.7
Caudatenucleus84.7
Cerebellum88.8
CerebellumPeduncles53.85
CiliaryGanglion37.8
CingulateCortex80.35
Colorectaladenocarcinoma32.4
DorsalRootGanglion18.75
FetalThyroid123.05
Fetalbrain51.55
Fetalliver68.65
Fetallung115.8
GlobusPallidus21.7
Heart396
Hypothalamus182.5
Kidney91.6
Leukemia_chronicMyelogenousK-56238.3
Leukemia_promyelocytic-HL-6042.4
Leukemialymphoblastic(MOLT-4)31.2
Liver292.55
Lung498.8
Lymphnode202.5
Lymphoma_burkitts(Daudi)168.35
Lymphoma_burkitts(Raji)114.05
MedullaOblongata90.35
OccipitalLobe58.85
OlfactoryBulb117.05
Ovary16
Pancreas129.35
PancreaticIslet114.2
ParietalLobe84.4
Pituitary258.85
Placenta165.1
Pons55.55
PrefrontalCortex140.5
Prostate322.35
Salivarygland83.4
SkeletalMuscle48.85
Skin43.35
SmoothMuscle96.8
Spinalcord145.95
SubthalamicNucleus51.7
SuperiorCervicalGanglion61.85
TemporalLobe41.8
Testis74.45
TestisGermCell62.1
TestisIntersitial27.65
TestisLeydigCell46.1
TestisSeminiferousTubule39.3
Thalamus125.2
Thymus434.2
Thyroid162.75
Tongue52.15
Tonsil283.95
Trachea204.4
TrigeminalGanglion20.85
Uterus176.65
UterusCorpus168.3
WholeBlood1338.8
Wholebrain208.2
colon131.4
pineal_day86.32
pineal_night73.14
retina245.25
small_intestine99.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14220_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.17 ± 0.56
Basal Forebrain4.98 ± 0.27
Basal Part of Pons4.95 ± 0.31
Cerebellar Cortex4.74 ± 0.22
Cerebellar Nuclei5.22 ± 0.32
Claustrum5.43 ± 0.49
Epithalamus4.79 ± 0.25
Frontal Lobe4.95 ± 0.34
Globus Pallidus5.7 ± 0.27
Hypothalamus4.87 ± 0.27
Insula4.86 ± 0.46
Limbic Lobe5.05 ± 0.47
Mesencephalon5.09 ± 0.47
Myelencephalon5.1 ± 0.44
Occipital Lobe5.09 ± 0.37
Parietal Lobe4.98 ± 0.41
Pontine Tegmentum5 ± 0.39
Striatum5.29 ± 0.4
Subthalamus5 ± 0.45
Temporal Lobe4.99 ± 0.44
Thalamus5.19 ± 0.31
White Matter5.18 ± 0.3
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Isgf3gCBCerebellum62.41
64.33
Isgf3gCTXCerebral cortex72.14
65.52
Isgf3gHIPHippocampal region70.25
75.59
Isgf3gHPFHippocampal formation84.55
77.81
Isgf3gHYHypothalamus69.48
47.9
Isgf3gLSXLateral septal complex55.18
44.92
Isgf3gMBMidbrain62.35
49.08
Isgf3gMYMedulla81.99
83.38
Isgf3gOLFOlfactory bulb78.24
66.93
Isgf3gPPons74.08
69.42
Isgf3gPALPallidum69.71
64.65
Isgf3gRHPRetrohippocampal region94.37
82.8
Isgf3gsAMYStriatum-like amygdalar nuclei67.12
51.36
Isgf3gSTRStriatum60.71
37.95
Isgf3gSTRdStriatum dorsal region58.05
33.54
Isgf3gSTRvStriatum ventral region66.87
41.62
Isgf3gTHThalamus71.47
55.25
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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