AutismKB 2.0

Annotation Detail for TUBB3


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Basic Information Top
Gene Symbol:TUBB3 ( CFEOM3A,TUBB4,beta-4 )
Gene Full Name: tubulin, beta 3
Band: 16q24.3
Quick LinksEntrez ID:10381; OMIM: 602661; Uniprot ID:TBB3_HUMAN; ENSEMBL ID: ENSG00000198211; HGNC ID: 20772
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body22 / 70761310
blastocyst8 / 62319128
fetus503 / 564012891
neonate3 / 3109796
infant33 / 236201397
juvenile63 / 555561133
adult274 / 1939121141
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor13 / 94178138
cervical tumor3 / 3436687
chondrosarcoma4 / 8282348
colorectal tumor1 / 1142468
esophageal tumor4 / 17290231
gastrointestinal tumor14 / 119369117
germ cell tumor188 / 263845712
glioma23 / 106883215
head and neck tumor22 / 136302161
kidney tumor25 / 68959362
leukemia3 / 9584231
liver tumor15 / 96359155
lung tumor58 / 103127562
lymphoma18 / 71755250
non-neoplasia11 / 97250113
normal918 / 3360307273
ovarian tumor11 / 76682143
pancreatic tumor19 / 104616181
primitive neuroectodermal tumor of the CNS127 / 1256801010
prostate cancer11 / 102680107
retinoblastoma62 / 463561337
skin tumor38 / 124949304
soft tissue/muscle tissue tumor26 / 125191207
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone5 / 7165569
bone marrow1 / 4880120
brain887 / 1100989805
cervix3 / 4817162
connective tissue11 / 14925573
ear0 / 162120 
embryonic tissue62 / 215722287
esophagus4 / 20209197
eye89 / 211054421
heart1 / 8962611
intestine9 / 23447238
kidney45 / 211777212
larynx0 / 241450 
liver17 / 20774381
lung65 / 336974192
lymph6 / 44270135
lymph node2 / 9161021
mammary gland14 / 15327191
mouth2 / 6705229
muscle4 / 10771537
nerve17 / 157681078
ovary12 / 102051117
pancreas20 / 21481293
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland2 / 16585120
placenta6 / 28082521
prostate13 / 18934568
salivary gland14 / 20155694
skin48 / 210574227
spleen0 / 539520 
stomach9 / 9661993
testis64 / 330442193
thymus0 / 811310 
thyroid5 / 47473105
tonsil4 / 16999235
trachea1 / 5241319
umbilical cord1 / 1368073
uterus30 / 232878128
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213476_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts681.65
Adipocyte826.8
AdrenalCortex166.2
Adrenalgland165.85
Amygdala7951.1
Appendix130.55
AtrioventricularNode16.55
BDCA4+_DentriticCells282.85
Bonemarrow289.25
BronchialEpithelialCells1583.3
CD105+_Endothelial1460.9
CD14+_Monocytes117.75
CD19+_BCells(neg._sel.)76.8
CD33+_Myeloid311.3
CD34+488.05
CD4+_Tcells38.45
CD56+_NKCells81.75
CD71+_EarlyErythroid2024
CD8+_Tcells49
CardiacMyocytes2995.15
Caudatenucleus1779.55
Cerebellum3510.6
CerebellumPeduncles3434.9
CiliaryGanglion684.4
CingulateCortex2240.4
Colorectaladenocarcinoma3162.85
DorsalRootGanglion2151.05
FetalThyroid350.2
Fetalbrain13658.45
Fetalliver382.1
Fetallung435.15
GlobusPallidus1735.05
Heart875.05
Hypothalamus6121.9
Kidney133.65
Leukemia_chronicMyelogenousK-562934.9
Leukemia_promyelocytic-HL-60481.05
Leukemialymphoblastic(MOLT-4)366.7
Liver578.7
Lung1044.5
Lymphnode57.5
Lymphoma_burkitts(Daudi)733.05
Lymphoma_burkitts(Raji)525.35
MedullaOblongata2173.1
OccipitalLobe4344.1
OlfactoryBulb517.8
Ovary74.4
Pancreas125.65
PancreaticIslet232
ParietalLobe3230.65
Pituitary398.1
Placenta605.2
Pons1887.7
PrefrontalCortex4362.2
Prostate925.25
Salivarygland50.8
SkeletalMuscle28.05
Skin102.5
SmoothMuscle2586.6
Spinalcord2222.55
SubthalamicNucleus2577.95
SuperiorCervicalGanglion156.9
TemporalLobe3934.2
Testis2290.95
TestisGermCell1394.25
TestisIntersitial1748.45
TestisLeydigCell1275.25
TestisSeminiferousTubule1137.7
Thalamus5338.7
Thymus490.4
Thyroid361.3
Tongue367.5
Tonsil427.1
Trachea273.85
TrigeminalGanglion697.7
Uterus534.2
UterusCorpus143.7
WholeBlood105.45
Wholebrain7461.8
colon623.3
pineal_day2268.28
pineal_night1801.42
retina1696.95
small_intestine657.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P258633
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.69 ± 0.71
Basal Forebrain10.92 ± 0.43
Basal Part of Pons11.81 ± 0.39
Cerebellar Cortex11.29 ± 0.27
Cerebellar Nuclei11.12 ± 0.34
Claustrum10.9 ± 0.66
Epithalamus11.49 ± 0.52
Frontal Lobe11.45 ± 0.5
Globus Pallidus10.12 ± 0.54
Hypothalamus11.89 ± 0.52
Insula11.51 ± 0.31
Limbic Lobe11.05 ± 0.78
Mesencephalon10.99 ± 0.57
Myelencephalon11.06 ± 0.81
Occipital Lobe10.32 ± 0.8
Parietal Lobe11.05 ± 0.56
Pontine Tegmentum11.02 ± 0.65
Striatum9.96 ± 0.64
Subthalamus11.62 ± 0.42
Temporal Lobe11.45 ± 0.54
Thalamus11.16 ± 0.5
White Matter9.06 ± 0.26
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tubb3CBCerebellum100
100
Tubb3CTXCerebral cortex100
100
Tubb3HIPHippocampal region100
100
Tubb3HPFHippocampal formation100
100
Tubb3HYHypothalamus100
100
Tubb3LSXLateral septal complex100
100
Tubb3MBMidbrain100
100
Tubb3MYMedulla91.72
100
Tubb3OLFOlfactory bulb100
100
Tubb3PPons98.69
100
Tubb3PALPallidum100
100
Tubb3RHPRetrohippocampal region100
100
Tubb3sAMYStriatum-like amygdalar nuclei100
100
Tubb3STRStriatum100
100
Tubb3STRdStriatum dorsal region100
100
Tubb3STRvStriatum ventral region100
100
Tubb3THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000436 15 63 77 AILVDLEPGTMDSVR Peptide Atlas
TBB3_HUMAN_0 0 0 0 MREIVHIQAGQCGNQIGAK PRIDE
TBB3_HUMAN_103 18 103 120 GHYTEGAELVDSVLDVVR PRIDE
TBB3_HUMAN_103 19 103 121 GHYTEGAELVDSVLDVVRK PRIDE
TBB3_HUMAN_154 20 154 173 VREEYPDRIMNTFSVVPSPK PRIDE
TBB3_HUMAN_162 12 162 173 IMNTFSVVPSPK PRIDE
TBB3_HUMAN_2 17 2 18 EIVHIQAGQCGNQIGAK PRIDE
TBB3_HUMAN_216 25 216 240 LATPTYGDLNHLVSATMSGVTTSLR PRIDE
TBB3_HUMAN_216 35 216 250 LATPTYGDLNHLVSATMSGVTTSLRFPGQLNADLR PRIDE
TBB3_HUMAN_217 25 217 241 LATPTYGDLNHLVSATMSGVTTSLR PRIDE
TBB3_HUMAN_241 10 241 250 FPGQLNADLR PRIDE
TBB3_HUMAN_241 11 241 251 FPGQLNADLRK PRIDE
TBB3_HUMAN_242 10 242 251 FPGQLNADLR PRIDE
TBB3_HUMAN_251 11 251 261 KLAVNMVPFPR PRIDE
TBB3_HUMAN_252 10 252 261 LAVNMVPFPR PRIDE
TBB3_HUMAN_252 11 252 262 KLAVNMVPFPR PRIDE
TBB3_HUMAN_262 14 262 275 LHFFMPGFAPLTAR PRIDE
TBB3_HUMAN_263 14 263 276 LHFFMPGFAPLTAR PRIDE
TBB3_HUMAN_282 15 282 296 ALTVPELTQQMFDAK PRIDE
TBB3_HUMAN_297 9 297 305 NMMAACDPR PRIDE
TBB3_HUMAN_309 9 309 317 YLTVATVFR PRIDE
TBB3_HUMAN_324 12 324 335 EVDEQMLAIQSK PRIDE
TBB3_HUMAN_325 12 325 336 EVDEQMLAIQSK PRIDE
TBB3_HUMAN_336 14 336 349 NSSYFVEWIPNNVK PRIDE
TBB3_HUMAN_379 11 379 389 RISEQFTAMFR PRIDE
TBB3_HUMAN_380 10 380 389 ISEQFTAMFR PRIDE
TBB3_HUMAN_46 12 46 57 ISVYYNEASSHK PRIDE
TBB3_HUMAN_46 16 46 61 ISVYYNEASSHKYVPR PRIDE
TBB3_HUMAN_62 15 62 76 AILVDLEPGTMDSVR PRIDE
TBB3_HUMAN_77 26 77 102 SGAFGHLFRPDNFIFGQSGAGNNWAK PRIDE
TBB3_HUMAN_78 9 78 86 SGAFGHLFR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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