AutismKB 2.0

Annotation Detail for NOD1


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Basic Information Top
Gene Symbol:NOD1 ( CARD4,CLR7.1,NLRC1 )
Gene Full Name: nucleotide-binding oligomerization domain containing 1
Band: 7p14.3
Quick LinksEntrez ID:10392; OMIM: 605980; Uniprot ID:NOD1_HUMAN; ENSEMBL ID: ENSG00000106100; HGNC ID: 16390
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst0 / 623190 
fetus14 / 56401224
neonate1 / 3109732
infant0 / 236200 
juvenile1 / 5555617
adult44 / 193912122
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor2 / 3436658
chondrosarcoma6 / 8282372
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor10 / 26384537
glioma7 / 10688365
head and neck tumor5 / 13630236
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor0 / 963590 
lung tumor5 / 10312748
lymphoma1 / 7175513
non-neoplasia2 / 9725020
normal56 / 336030716
ovarian tumor5 / 7668265
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma3 / 4635664
skin tumor1 / 1249498
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites2 / 4001549
bladder0 / 297570 
blood4 / 12347832
bone2 / 7165527
bone marrow1 / 4880120
brain16 / 110098914
cervix2 / 4817141
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye4 / 21105418
heart0 / 896260 
intestine7 / 23447229
kidney1 / 2117774
larynx3 / 24145124
liver2 / 2077439
lung19 / 33697456
lymph1 / 4427022
lymph node1 / 9161010
mammary gland0 / 1532710 
mouth1 / 6705214
muscle5 / 10771546
nerve2 / 15768126
ovary5 / 10205148
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate1 / 1893455
salivary gland0 / 201550 
skin3 / 21057414
spleen3 / 5395255
stomach0 / 966190 
testis8 / 33044224
thymus1 / 8113112
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus9 / 23287838
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221073_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.55
Adipocyte6.05
AdrenalCortex10.3
Adrenalgland11.1
Amygdala6.15
Appendix8.7
AtrioventricularNode5.1
BDCA4+_DentriticCells9.85
Bonemarrow23
BronchialEpithelialCells5.95
CD105+_Endothelial6.3
CD14+_Monocytes6.35
CD19+_BCells(neg._sel.)15.4
CD33+_Myeloid10.45
CD34+17.15
CD4+_Tcells10.8
CD56+_NKCells9.9
CD71+_EarlyErythroid5.6
CD8+_Tcells9.4
CardiacMyocytes7.8
Caudatenucleus5.35
Cerebellum8.75
CerebellumPeduncles7.15
CiliaryGanglion22.4
CingulateCortex12.85
Colorectaladenocarcinoma11.75
DorsalRootGanglion11.15
FetalThyroid16.3
Fetalbrain5.9
Fetalliver5.5
Fetallung9.25
GlobusPallidus4.55
Heart7.85
Hypothalamus6.5
Kidney5.3
Leukemia_chronicMyelogenousK-5625.4
Leukemia_promyelocytic-HL-607.95
Leukemialymphoblastic(MOLT-4)10.7
Liver7.95
Lung9.6
Lymphnode13.65
Lymphoma_burkitts(Daudi)11.6
Lymphoma_burkitts(Raji)9.95
MedullaOblongata6.4
OccipitalLobe5.45
OlfactoryBulb7.95
Ovary13.5
Pancreas5.9
PancreaticIslet7.6
ParietalLobe6.45
Pituitary7.3
Placenta6.4
Pons6
PrefrontalCortex7.75
Prostate7.2
Salivarygland6.45
SkeletalMuscle8.05
Skin17.75
SmoothMuscle6.2
Spinalcord6.25
SubthalamicNucleus5.45
SuperiorCervicalGanglion8.95
TemporalLobe8.65
Testis5.35
TestisGermCell5.1
TestisIntersitial4.8
TestisLeydigCell6.35
TestisSeminiferousTubule5.8
Thalamus6.3
Thymus6.55
Thyroid7.6
Tongue6.3
Tonsil8.15
Trachea7.6
TrigeminalGanglion6.35
Uterus6.5
UterusCorpus12.85
WholeBlood6.45
Wholebrain5.35
colon6
pineal_day7.28
pineal_night7.1
retina7.225
small_intestine5.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16008_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.86 ± 1.09
Basal Forebrain2.24 ± 0.16
Basal Part of Pons2.09 ± 0.67
Cerebellar Cortex2.44 ± 0.84
Cerebellar Nuclei2.95 ± 0.84
Claustrum3.33 ± 0.9
Epithalamus2.44 ± 0.83
Frontal Lobe2.35 ± 0.73
Globus Pallidus3.01 ± 0.42
Hypothalamus2.4 ± 0.83
Insula2.29 ± 0.61
Limbic Lobe2.48 ± 0.65
Mesencephalon2.64 ± 0.74
Myelencephalon2.58 ± 0.73
Occipital Lobe2.64 ± 0.81
Parietal Lobe2.4 ± 0.72
Pontine Tegmentum2.51 ± 0.75
Striatum2.73 ± 0.63
Subthalamus2.55 ± 0.69
Temporal Lobe2.44 ± 0.72
Thalamus2.49 ± 0.63
White Matter2.73 ± 0.26
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Card4CBCerebellum3.38
3.22
Card4CTXCerebral cortex0.75
0.59
Card4HIPHippocampal region0.7
0.77
Card4HPFHippocampal formation0.59
0.58
Card4HYHypothalamus0.69
0.26
Card4LSXLateral septal complex0.3
0.24
Card4MBMidbrain1.02
0.75
Card4MYMedulla9.49
5.65
Card4OLFOlfactory bulb1.22
1.83
Card4PPons2.06
1.12
Card4PALPallidum0.42
0.25
Card4RHPRetrohippocampal region0.45
0.35
Card4sAMYStriatum-like amygdalar nuclei0.69
0.52
Card4STRStriatum0.58
0.44
Card4STRdStriatum dorsal region0.69
0.53
Card4STRvStriatum ventral region0.09
0.09
Card4THThalamus0.73
0.58
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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