Annotation Detail for NDRG1
Basic Information Top
| Gene Symbol: | NDRG1 ( CAP43,CMT4D,DRG1,GC4,HMSNL,NDR1,NMSL,PROXY1,RIT42,RTP,TARG1,TDD5 ) |
|---|---|
| Gene Full Name: | N-myc downstream regulated 1 |
| Band: | 8q24.22 |
| Quick Links | Entrez ID:10397; OMIM: 605262; Uniprot ID:NDRG1_HUMAN; ENSEMBL ID: ENSG00000104419; HGNC ID: 7679 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.618002
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 13 / 70761 | 183 |  |
| blastocyst | 4 / 62319 | 64 | |
| fetus | 448 / 564012 | 794 |  |
| neonate | 22 / 31097 | 707 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 7 / 55556 | 125 | |
| adult | 574 / 1939121 | 296 | |
| embryoid body | 0 / 70761 | 0 | |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 0 / 564012 | 0 | |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 0 / 55556 | 0 | |
| adult | 3 / 1939121 | 1 |  |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 3 / 12794 | 234 | |
| bladder carcinoma | 3 / 17475 | 171 | |
| breast (mammary gland) tumor | 21 / 94178 | 222 | |
| cervical tumor | 15 / 34366 | 436 | |
| chondrosarcoma | 35 / 82823 | 422 | |
| colorectal tumor | 16 / 114246 | 140 | |
| esophageal tumor | 18 / 17290 | 1041 |  |
| gastrointestinal tumor | 25 / 119369 | 209 | |
| germ cell tumor | 16 / 263845 | 60 | |
| glioma | 36 / 106883 | 336 | |
| head and neck tumor | 744 / 136302 | 5458 | |
| kidney tumor | 61 / 68959 | 884 | |
| leukemia | 20 / 95842 | 208 | |
| liver tumor | 15 / 96359 | 155 | |
| lung tumor | 54 / 103127 | 523 | |
| lymphoma | 1 / 71755 | 13 |  |
| non-neoplasia | 111 / 97250 | 1141 | |
| normal | 2087 / 3360307 | 621 | |
| ovarian tumor | 27 / 76682 | 352 | |
| pancreatic tumor | 21 / 104616 | 200 | |
| primitive neuroectodermal tumor of the CNS | 10 / 125680 | 79 | |
| prostate cancer | 56 / 102680 | 545 | |
| retinoblastoma | 2 / 46356 | 43 | |
| skin tumor | 13 / 124949 | 104 | |
| soft tissue/muscle tissue tumor | 8 / 125191 | 63 | |
| uterine tumor | 20 / 90257 | 221 | |
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 0 / 94178 | 0 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 1 / 82823 | 12 | |
| colorectal tumor | 0 / 114246 | 0 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 0 / 119369 | 0 | |
| germ cell tumor | 0 / 263845 | 0 | |
| glioma | 0 / 106883 | 0 | |
| head and neck tumor | 0 / 136302 | 0 | |
| kidney tumor | 0 / 68959 | 0 | |
| leukemia | 0 / 95842 | 0 | |
| liver tumor | 0 / 96359 | 0 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 0 / 97250 | 0 | |
| normal | 3 / 3360307 | 0 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 0 / 104616 | 0 | |
| primitive neuroectodermal tumor of the CNS | 0 / 125680 | 0 | |
| prostate cancer | 1 / 102680 | 9 |  |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 0 / 124949 | 0 | |
| soft tissue/muscle tissue tumor | 0 / 125191 | 0 | |
| uterine tumor | 0 / 90257 | 0 |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 5 / 13106 | 381 | |
| adrenal gland | 19 / 33197 | 572 | |
| ascites | 5 / 40015 | 124 | |
| bladder | 18 / 29757 | 604 | |
| blood | 24 / 123478 | 194 | |
| bone | 23 / 71655 | 320 | |
| bone marrow | 9 / 48801 | 184 | |
| brain | 1263 / 1100989 | 1147 | |
| cervix | 19 / 48171 | 394 | |
| connective tissue | 122 / 149255 | 817 | |
| ear | 5 / 16212 | 308 | |
| embryonic tissue | 20 / 215722 | 92 | |
| esophagus | 19 / 20209 | 940 | |
| eye | 44 / 211054 | 208 | |
| heart | 29 / 89626 | 323 | |
| intestine | 79 / 234472 | 336 | |
| kidney | 178 / 211777 | 840 | |
| larynx | 19 / 24145 | 786 | |
| liver | 34 / 207743 | 163 | |
| lung | 140 / 336974 | 415 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 8 / 91610 | 87 | |
| mammary gland | 37 / 153271 | 241 | |
| mouth | 754 / 67052 | 11245 | |
| muscle | 8 / 107715 | 74 | |
| nerve | 7 / 15768 | 443 | |
| ovary | 32 / 102051 | 313 | |
| pancreas | 29 / 214812 | 135 | |
| parathyroid | 4 / 20539 | 194 | |
| pharynx | 16 / 41328 | 387 | |
| pituitary gland | 3 / 16585 | 180 | |
| placenta | 83 / 280825 | 295 | |
| prostate | 263 / 189345 | 1388 | |
| salivary gland | 1 / 20155 | 49 | |
| skin | 60 / 210574 | 284 | |
| spleen | 27 / 53952 | 500 | |
| stomach | 30 / 96619 | 310 | |
| testis | 89 / 330442 | 269 | |
| thymus | 188 / 81131 | 2317 | |
| thyroid | 13 / 47473 | 273 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 23 / 52413 | 438 | |
| umbilical cord | 2 / 13680 | 146 | |
| uterus | 80 / 232878 | 343 | |
| vascular | 42 / 51780 | 811 | |
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 0 / 123478 | 0 | |
| bone | 1 / 71655 | 13 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 1 / 1100989 | 0 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 0 / 149255 | 0 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 0 / 215722 | 0 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 1 / 211054 | 4 | |
| heart | 0 / 89626 | 0 | |
| intestine | 0 / 234472 | 0 | |
| kidney | 0 / 211777 | 0 | |
| larynx | 0 / 24145 | 0 | |
| liver | 0 / 207743 | 0 | |
| lung | 0 / 336974 | 0 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 0 / 91610 | 0 | |
| mammary gland | 0 / 153271 | 0 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 0 / 107715 | 0 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 0 / 102051 | 0 | |
| pancreas | 0 / 214812 | 0 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 1 / 280825 | 3 | |
| prostate | 1 / 189345 | 5 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 0 / 210574 | 0 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 0 / 96619 | 0 | |
| testis | 0 / 330442 | 0 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 0 / 232878 | 0 | |
| vascular | 0 / 51780 | 0 |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 200632_s_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 8.25 | |
| Adipocyte | 220.55 | |
| AdrenalCortex | 441.8 | |
| Adrenalgland | 201.1 | |
| Amygdala | 440.75 | |
| Appendix | 351.4 | |
| AtrioventricularNode | 828.75 | |
| BDCA4+_DentriticCells | 843.85 | |
| Bonemarrow | 98.7 | |
| BronchialEpithelialCells | 2103.05 | |
| CD105+_Endothelial | 65.15 | |
| CD14+_Monocytes | 363.55 | |
| CD19+_BCells(neg._sel.) | 124.55 | |
| CD33+_Myeloid | 391.8 | |
| CD34+ | 169 | |
| CD4+_Tcells | 177.55 | |
| CD56+_NKCells | 198 | |
| CD71+_EarlyErythroid | 44.2 | |
| CD8+_Tcells | 155.45 | |
| CardiacMyocytes | 215.55 | |
| Caudatenucleus | 526.7 | |
| Cerebellum | 156.4 | |
| CerebellumPeduncles | 307.3 | |
| CiliaryGanglion | 632.95 | |
| CingulateCortex | 613.65 | |
| Colorectaladenocarcinoma | 137.1 | |
| DorsalRootGanglion | 1041.1 | |
| FetalThyroid | 291.3 | |
| Fetalbrain | 441.5 | |
| Fetalliver | 109.95 | |
| Fetallung | 463.9 | |
| GlobusPallidus | 215 | |
| Heart | 141.45 | |
| Hypothalamus | 1110.05 | |
| Kidney | 722.2 | |
| Leukemia_chronicMyelogenousK-562 | 37.4 | |
| Leukemia_promyelocytic-HL-60 | 22.65 | |
| Leukemialymphoblastic(MOLT-4) | 35.75 | |
| Liver | 66 | |
| Lung | 575.6 | |
| Lymphnode | 185.65 | |
| Lymphoma_burkitts(Daudi) | 23.1 | |
| Lymphoma_burkitts(Raji) | 10.1 | |
| MedullaOblongata | 537.3 | |
| OccipitalLobe | 509.55 | |
| OlfactoryBulb | 3019.35 | |
| Ovary | 238.4 | |
| Pancreas | 710.25 | |
| PancreaticIslet | 373.1 | |
| ParietalLobe | 605.6 | |
| Pituitary | 413.25 | |
| Placenta | 810.35 | |
| Pons | 391 | |
| PrefrontalCortex | 984.25 | |
| Prostate | 2839.55 | |
| Salivarygland | 225 | |
| SkeletalMuscle | 49.45 | |
| Skin | 593.2 | |
| SmoothMuscle | 260.75 | |
| Spinalcord | 1403.25 | |
| SubthalamicNucleus | 453.7 | |
| SuperiorCervicalGanglion | 409.2 | |
| TemporalLobe | 329.4 | |
| Testis | 186.65 | |
| TestisGermCell | 326 | |
| TestisIntersitial | 88.6 | |
| TestisLeydigCell | 102.65 | |
| TestisSeminiferousTubule | 149.45 | |
| Thalamus | 925.95 | |
| Thymus | 181.65 | |
| Thyroid | 358.6 | |
| Tongue | 1135.65 | |
| Tonsil | 331.1 | |
| Trachea | 219.35 | |
| TrigeminalGanglion | 1052 | |
| Uterus | 247.95 | |
| UterusCorpus | 682.75 | |
| WholeBlood | 271.2 | |
| Wholebrain | 429.75 | |
| colon | 251.75 | |
| pineal_day | 364.8 | |
| pineal_night | 431.5 | |
| retina | 659.1 | |
| small_intestine | 563.2 | |
- Probe name: A_23_P20494
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 9.43 ± 0.65 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 10.69 ± 0.42 | |
| Basal Part of Pons | 10.25 ± 0.69 | |
| Cerebellar Cortex | 9.58 ± 0.35 | |
| Cerebellar Nuclei | 11.24 ± 0.59 | |
| Claustrum | 9.57 ± 1.19 | |
| Epithalamus | 9.76 ± 0.9 | |
| Frontal Lobe | 10.26 ± 0.8 | |
| Globus Pallidus | 12.17 ± 0.33 | |
| Hypothalamus | 9.98 ± 0.41 | |
| Insula | 9.83 ± 0.36 | |
| Limbic Lobe | 9.62 ± 0.67 | |
| Mesencephalon | 10.43 ± 0.92 | |
| Myelencephalon | 10.3 ± 0.73 | |
| Occipital Lobe | 9.98 ± 0.71 | |
| Parietal Lobe | 10.19 ± 0.72 | |
| Pontine Tegmentum | 10.45 ± 0.54 | |
| Striatum | 11.03 ± 0.6 | |
| Subthalamus | 10.95 ± 0.3 | |
| Temporal Lobe | 10.1 ± 0.53 | |
| Thalamus | 10.79 ± 0.53 | |
| White Matter | 12.89 ± 0.55 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Ndrg1 | CB | Cerebellum | 62.38 | |
| 78.83 | | |||
| Ndrg1 | CTX | Cerebral cortex | 61.66 | |
| 50.39 | | |||
| Ndrg1 | HIP | Hippocampal region | 61.25 | |
| 75 | | |||
| Ndrg1 | HPF | Hippocampal formation | 71.86 | |
| 78.62 | | |||
| Ndrg1 | HY | Hypothalamus | 92.88 | |
| 77.32 | | |||
| Ndrg1 | LSX | Lateral septal complex | 71.85 | |
| 61.95 | | |||
| Ndrg1 | MB | Midbrain | 100 | |
| 91.77 | | |||
| Ndrg1 | MY | Medulla | 100 | |
| 100 | | |||
| Ndrg1 | OLF | Olfactory bulb | 58.71 | |
| 51.86 | | |||
| Ndrg1 | P | Pons | 100 | |
| 100 | | |||
| Ndrg1 | PAL | Pallidum | 96.87 | |
| 85.45 | | |||
| Ndrg1 | RHP | Retrohippocampal region | 89.7 | |
| 83.06 | | |||
| Ndrg1 | sAMY | Striatum-like amygdalar nuclei | 62.86 | |
| 49.09 | | |||
| Ndrg1 | STR | Striatum | 73.53 | |
| 61.77 | | |||
| Ndrg1 | STRd | Striatum dorsal region | 82.87 | |
| 72.69 | | |||
| Ndrg1 | STRv | Striatum ventral region | 51.47 | |
| 37.33 | | |||
| Ndrg1 | TH | Thalamus | 100 | |
| 100 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| NDRG1_HUMAN_132 | 16 | 132 | 147 | SIIGMGTGAGAYILTR | PRIDE |
| NDRG1_HUMAN_285 | 15 | 285 | 299 | MADCGGLPQISQPAK | PRIDE |
| NDRG1_HUMAN_361 | 27 | 361 | 387 | SRSHTSEGAHLDITPNSGAAGNSAGPK | PRIDE |
| PAp00005489 | 15 | 286 | 300 | MADCGGLPQISQPAK | Peptide Atlas |