AutismKB 2.0

Annotation Detail for NDC80


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Basic Information Top
Gene Symbol:NDC80 ( HEC,HEC1,KNTC2,TID3,hsNDC80 )
Gene Full Name: NDC80 homolog, kinetochore complex component (S. cerevisiae)
Band: 18p11.32
Quick LinksEntrez ID:10403; OMIM: 607272; Uniprot ID:NDC80_HUMAN; ENSEMBL ID: ENSG00000080986; HGNC ID: 16909
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst2 / 6231932
fetus17 / 56401230
neonate5 / 31097160
infant3 / 23620127
juvenile7 / 55556125
adult43 / 193912122
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma4 / 17475228
breast (mammary gland) tumor4 / 9417842
cervical tumor7 / 34366203
chondrosarcoma5 / 8282360
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor17 / 26384564
glioma8 / 10688374
head and neck tumor4 / 13630229
kidney tumor1 / 6895914
leukemia7 / 9584273
liver tumor4 / 9635941
lung tumor0 / 1031270 
lymphoma3 / 7175541
non-neoplasia2 / 9725020
normal69 / 336030720
ovarian tumor1 / 7668213
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS14 / 125680111
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor7 / 12494956
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder6 / 29757201
blood5 / 12347840
bone3 / 7165541
bone marrow4 / 4880181
brain25 / 110098922
cervix7 / 48171145
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue15 / 21572269
esophagus0 / 202090 
eye0 / 2110540 
heart6 / 8962666
intestine5 / 23447221
kidney2 / 2117779
larynx0 / 241450 
liver11 / 20774352
lung3 / 3369748
lymph1 / 4427022
lymph node1 / 9161010
mammary gland9 / 15327158
mouth1 / 6705214
muscle3 / 10771527
nerve0 / 157680 
ovary1 / 1020519
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta6 / 28082521
prostate4 / 18934521
salivary gland0 / 201550 
skin10 / 21057447
spleen0 / 539520 
stomach1 / 9661910
testis13 / 33044239
thymus11 / 81131135
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus8 / 23287834
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204162_at
Cell line Expression level Expression bar
721_B_lymphoblasts135.4
Adipocyte9.8
AdrenalCortex15
Adrenalgland9.3
Amygdala8.2
Appendix14.1
AtrioventricularNode13.55
BDCA4+_DentriticCells10.25
Bonemarrow11.6
BronchialEpithelialCells9.75
CD105+_Endothelial95.85
CD14+_Monocytes10.75
CD19+_BCells(neg._sel.)10.45
CD33+_Myeloid12.45
CD34+34.75
CD4+_Tcells10.7
CD56+_NKCells11.7
CD71+_EarlyErythroid79.65
CD8+_Tcells9.45
CardiacMyocytes24.05
Caudatenucleus9.05
Cerebellum8.15
CerebellumPeduncles12.95
CiliaryGanglion13.3
CingulateCortex10.8
Colorectaladenocarcinoma10.95
DorsalRootGanglion11.55
FetalThyroid10.35
Fetalbrain9.45
Fetalliver19.15
Fetallung6.7
GlobusPallidus9
Heart16.25
Hypothalamus10.3
Kidney9.35
Leukemia_chronicMyelogenousK-56224.45
Leukemia_promyelocytic-HL-6027.65
Leukemialymphoblastic(MOLT-4)16.85
Liver15.6
Lung10.1
Lymphnode8.45
Lymphoma_burkitts(Daudi)38.6
Lymphoma_burkitts(Raji)16.5
MedullaOblongata8.25
OccipitalLobe8.95
OlfactoryBulb7.95
Ovary8.15
Pancreas8.8
PancreaticIslet11.2
ParietalLobe11.8
Pituitary11.95
Placenta8.95
Pons10.6
PrefrontalCortex10.5
Prostate10.55
Salivarygland9.05
SkeletalMuscle18.85
Skin11.15
SmoothMuscle11.5
Spinalcord11.15
SubthalamicNucleus10.1
SuperiorCervicalGanglion17.7
TemporalLobe9.7
Testis8.7
TestisGermCell10.95
TestisIntersitial10
TestisLeydigCell11.7
TestisSeminiferousTubule14.85
Thalamus10.7
Thymus7.95
Thyroid10
Tongue12.5
Tonsil10.6
Trachea8.15
TrigeminalGanglion15.2
Uterus7.75
UterusCorpus10.3
WholeBlood10.5
Wholebrain6.6
colon9.15
pineal_day11.62
pineal_night11.08
retina11.125
small_intestine8.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P14156
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala1.88 ± 0.97
Basal Forebrain1.42 ± 0.17
Basal Part of Pons1.11 ± 0.33
Cerebellar Cortex1.23 ± 0.66
Cerebellar Nuclei1.71 ± 0.7
Claustrum2.33 ± 0.84
Epithalamus1.17 ± 0.71
Frontal Lobe1.32 ± 0.65
Globus Pallidus2.07 ± 0.36
Hypothalamus1.56 ± 0.71
Insula1.31 ± 0.51
Limbic Lobe1.44 ± 0.6
Mesencephalon1.6 ± 0.72
Myelencephalon1.47 ± 0.64
Occipital Lobe1.48 ± 0.5
Parietal Lobe1.42 ± 0.65
Pontine Tegmentum1.49 ± 0.65
Striatum1.68 ± 0.61
Subthalamus1.54 ± 0.56
Temporal Lobe1.32 ± 0.59
Thalamus1.43 ± 0.57
White Matter1.97 ± 0.28
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Kntc2RHPRetrohippocampal region0.17
0.2
Kntc2sAMYStriatum-like amygdalar nuclei0.21
0.12
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
NDC80_HUMAN_53 7 53 59 KVSLFGK PRIDE
NDC80_HUMAN_60 8 60 67 RTSGHGSR PRIDE
NDC80_HUMAN_68 12 68 79 NSQLGIFSSSEK PRIDE
PAp00066424 12 463 474 ELLNETEEEINK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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