AutismKB 2.0

Annotation Detail for YAP1


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Basic Information Top
Gene Symbol:YAP1 ( YAP,YAP2,YAP65,YKI )
Gene Full Name: Yes-associated protein 1
Band: 11q22.1
Quick LinksEntrez ID:10413; OMIM: 606608; Uniprot ID:YAP1_HUMAN; ENSEMBL ID: ENSG00000137693; HGNC ID: 16262
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body14 / 70761197
blastocyst4 / 6231964
fetus41 / 56401272
neonate0 / 310970 
infant0 / 236200 
juvenile6 / 55556107
adult166 / 193912185
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor7 / 34366203
chondrosarcoma10 / 82823120
colorectal tumor15 / 114246131
esophageal tumor1 / 1729057
gastrointestinal tumor3 / 11936925
germ cell tumor6 / 26384522
glioma2 / 10688318
head and neck tumor6 / 13630244
kidney tumor4 / 6895958
leukemia4 / 9584241
liver tumor7 / 9635972
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia7 / 9725071
normal213 / 336030763
ovarian tumor2 / 7668226
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer6 / 10268058
retinoblastoma0 / 463560 
skin tumor4 / 12494932
soft tissue/muscle tissue tumor9 / 12519171
uterine tumor39 / 90257432
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder8 / 29757268
blood0 / 1234780 
bone7 / 7165597
bone marrow4 / 4880181
brain24 / 110098921
cervix7 / 48171145
connective tissue13 / 14925587
ear5 / 16212308
embryonic tissue34 / 215722157
esophagus1 / 2020949
eye7 / 21105433
heart9 / 89626100
intestine21 / 23447289
kidney11 / 21177751
larynx2 / 2414582
liver13 / 20774362
lung15 / 33697444
lymph0 / 442700 
lymph node0 / 916100 
mammary gland8 / 15327152
mouth2 / 6705229
muscle8 / 10771574
nerve0 / 157680 
ovary5 / 10205148
pancreas12 / 21481255
parathyroid10 / 20539486
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta22 / 28082578
prostate10 / 18934552
salivary gland1 / 2015549
skin33 / 210574156
spleen0 / 539520 
stomach1 / 9661910
testis3 / 3304429
thymus2 / 8113124
thyroid3 / 4747363
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus55 / 232878236
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213342_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.05
Adipocyte13.05
AdrenalCortex7.85
Adrenalgland6.25
Amygdala6.55
Appendix8.35
AtrioventricularNode7.95
BDCA4+_DentriticCells6.6
Bonemarrow7.2
BronchialEpithelialCells25.25
CD105+_Endothelial6.95
CD14+_Monocytes7.3
CD19+_BCells(neg._sel.)7.3
CD33+_Myeloid8.65
CD34+7.7
CD4+_Tcells6.6
CD56+_NKCells7.55
CD71+_EarlyErythroid6.6
CD8+_Tcells6
CardiacMyocytes9.95
Caudatenucleus6.25
Cerebellum5.6
CerebellumPeduncles8.25
CiliaryGanglion7.05
CingulateCortex7.2
Colorectaladenocarcinoma23.25
DorsalRootGanglion7.15
FetalThyroid6.85
Fetalbrain6.85
Fetalliver6.35
Fetallung9.45
GlobusPallidus5.45
Heart9.05
Hypothalamus7.1
Kidney6.35
Leukemia_chronicMyelogenousK-5626.3
Leukemia_promyelocytic-HL-606.25
Leukemialymphoblastic(MOLT-4)5.65
Liver9.65
Lung8.9
Lymphnode5.75
Lymphoma_burkitts(Daudi)9.1
Lymphoma_burkitts(Raji)9.95
MedullaOblongata6.25
OccipitalLobe6.2
OlfactoryBulb6.5
Ovary7.2
Pancreas7.6
PancreaticIslet7.7
ParietalLobe7.5
Pituitary8.2
Placenta14.45
Pons6.75
PrefrontalCortex8.35
Prostate10.15
Salivarygland5.65
SkeletalMuscle8.8
Skin6.4
SmoothMuscle8.15
Spinalcord7.45
SubthalamicNucleus6.4
SuperiorCervicalGanglion11.95
TemporalLobe6.45
Testis6
TestisGermCell5.9
TestisIntersitial5.95
TestisLeydigCell7.1
TestisSeminiferousTubule5.95
Thalamus7.1
Thymus5.3
Thyroid10.55
Tongue7.65
Tonsil6.85
Trachea7.75
TrigeminalGanglion10.7
Uterus17.65
UterusCorpus7.2
WholeBlood7.15
Wholebrain5.35
colon8.05
pineal_day8.24
pineal_night8.04
retina8.7
small_intestine8.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P104762
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.81 ± 0.34
Basal Forebrain8.19 ± 0.18
Basal Part of Pons6.69 ± 0.46
Cerebellar Cortex7.2 ± 0.28
Cerebellar Nuclei7.6 ± 0.34
Claustrum7.29 ± 0.48
Epithalamus9.22 ± 0.68
Frontal Lobe7.62 ± 0.53
Globus Pallidus9.22 ± 0.46
Hypothalamus7.97 ± 0.38
Insula7.72 ± 0.47
Limbic Lobe7.5 ± 0.7
Mesencephalon8 ± 0.49
Myelencephalon7.87 ± 0.66
Occipital Lobe7.84 ± 0.48
Parietal Lobe7.64 ± 0.56
Pontine Tegmentum7.86 ± 0.39
Striatum8.55 ± 0.43
Subthalamus7.27 ± 0.94
Temporal Lobe7.62 ± 0.43
Thalamus7.98 ± 0.38
White Matter6.8 ± 0.46
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Yap1CBCerebellum8.36
8.16
Yap1CTXCerebral cortex33.8
26.32
Yap1HIPHippocampal region28.61
30.87
Yap1HPFHippocampal formation28.54
27.91
Yap1HYHypothalamus10.81
8.29
Yap1LSXLateral septal complex5.69
5.35
Yap1MBMidbrain2.65
2.83
Yap1MYMedulla14.58
21.98
Yap1OLFOlfactory bulb41.1
34.83
Yap1PPons11.32
12.21
Yap1PALPallidum15.29
13.59
Yap1RHPRetrohippocampal region28.63
23.62
Yap1sAMYStriatum-like amygdalar nuclei30.13
22.03
Yap1STRStriatum14.26
10.21
Yap1STRdStriatum dorsal region12.81
9.06
Yap1STRvStriatum ventral region16.11
10.06
Yap1THThalamus7.85
7.12
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00131101 17 395 411 DESTDSGLSMSSYSVPR Peptide Atlas
YAP1_HUMAN_243 27 243 269 QPPPLAPQSPQGGVMGGSNSNQQQQMR PRIDE
YAP1_HUMAN_362 29 362 390 TPDDFLNSVDEMDTGDTINQSTLPSQQNR PRIDE
YAP1_HUMAN_77 11 77 87 TANVPQTVPMR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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