AutismKB 2.0

Annotation Detail for SPON2


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Basic Information Top
Gene Symbol:SPON2 ( DIL-1,DIL1,DKFZp686G21139,FLJ16313,FLJ22401,FLJ34460,M-spondin,Mindin )
Gene Full Name: spondin 2, extracellular matrix protein
Band: 4p16.3
Quick LinksEntrez ID:10417; OMIM: 605918; Uniprot ID:SPON2_HUMAN; ENSEMBL ID: ENSG00000159674; HGNC ID: 11253
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus15 / 56401226
neonate5 / 31097160
infant0 / 236200 
juvenile3 / 5555653
adult303 / 1939121156
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor5 / 34366145
chondrosarcoma7 / 8282384
colorectal tumor2 / 11424617
esophageal tumor4 / 17290231
gastrointestinal tumor5 / 11936941
germ cell tumor17 / 26384564
glioma4 / 10688337
head and neck tumor9 / 13630266
kidney tumor6 / 6895987
leukemia1 / 9584210
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal231 / 336030768
ovarian tumor4 / 7668252
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer163 / 1026801587
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites1 / 4001524
bladder1 / 2975733
blood9 / 12347872
bone3 / 7165541
bone marrow1 / 4880120
brain46 / 110098941
cervix6 / 48171124
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus5 / 20209247
eye3 / 21105414
heart5 / 8962655
intestine15 / 23447263
kidney15 / 21177770
larynx2 / 2414582
liver3 / 20774314
lung11 / 33697432
lymph0 / 442700 
lymph node0 / 916100 
mammary gland3 / 15327119
mouth0 / 670520 
muscle4 / 10771537
nerve12 / 15768761
ovary8 / 10205178
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta39 / 280825138
prostate188 / 189345992
salivary gland7 / 20155347
skin8 / 21057437
spleen4 / 5395274
stomach5 / 9661951
testis4 / 33044212
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord3 / 13680219
uterus39 / 232878167
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218638_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts15.1
Adipocyte702.9
AdrenalCortex55.4
Adrenalgland132.2
Amygdala22.2
Appendix110
AtrioventricularNode29.55
BDCA4+_DentriticCells210.5
Bonemarrow30.45
BronchialEpithelialCells16.85
CD105+_Endothelial13.45
CD14+_Monocytes8.05
CD19+_BCells(neg._sel.)21.15
CD33+_Myeloid22.05
CD34+29.3
CD4+_Tcells41.2
CD56+_NKCells7340.6
CD71+_EarlyErythroid9.95
CD8+_Tcells155.5
CardiacMyocytes25.45
Caudatenucleus30.95
Cerebellum74.85
CerebellumPeduncles74.4
CiliaryGanglion15.5
CingulateCortex31.45
Colorectaladenocarcinoma22
DorsalRootGanglion18.7
FetalThyroid32.45
Fetalbrain22.25
Fetalliver24
Fetallung156.6
GlobusPallidus16.5
Heart162.15
Hypothalamus23.2
Kidney37.3
Leukemia_chronicMyelogenousK-56222.1
Leukemia_promyelocytic-HL-6022.15
Leukemialymphoblastic(MOLT-4)164.5
Liver140.55
Lung343.4
Lymphnode40.75
Lymphoma_burkitts(Daudi)32.75
Lymphoma_burkitts(Raji)71.55
MedullaOblongata20.1
OccipitalLobe32.6
OlfactoryBulb21.4
Ovary14.8
Pancreas24.25
PancreaticIslet172.4
ParietalLobe38.9
Pituitary38.8
Placenta284.5
Pons24.6
PrefrontalCortex30.15
Prostate2075.85
Salivarygland24.85
SkeletalMuscle33.6
Skin45.45
SmoothMuscle53.55
Spinalcord26.25
SubthalamicNucleus21.1
SuperiorCervicalGanglion22.85
TemporalLobe30.05
Testis28.65
TestisGermCell34.7
TestisIntersitial23.6
TestisLeydigCell28.25
TestisSeminiferousTubule22.7
Thalamus21.1
Thymus19.1
Thyroid142.4
Tongue221.6
Tonsil24.6
Trachea52.45
TrigeminalGanglion22.05
Uterus465.3
UterusCorpus1015.75
WholeBlood99.7
Wholebrain23.4
colon29.7
pineal_day1429.18
pineal_night2914.52
retina47.025
small_intestine37.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P121533
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.59 ± 0.84
Basal Forebrain8.64 ± 0.47
Basal Part of Pons9.48 ± 0.32
Cerebellar Cortex8.78 ± 0.71
Cerebellar Nuclei6.69 ± 0.81
Claustrum6.68 ± 1.2
Epithalamus10.07 ± 0.73
Frontal Lobe8.39 ± 0.72
Globus Pallidus5.46 ± 0.88
Hypothalamus8.36 ± 1
Insula8.65 ± 0.57
Limbic Lobe7.65 ± 0.87
Mesencephalon7.32 ± 0.86
Myelencephalon7.74 ± 1.12
Occipital Lobe6.25 ± 0.68
Parietal Lobe7.2 ± 0.87
Pontine Tegmentum7.19 ± 0.76
Striatum7.91 ± 0.85
Subthalamus6.03 ± 0.89
Temporal Lobe7.82 ± 0.85
Thalamus6.98 ± 0.7
White Matter5.76 ± 0.41
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00042199 28 59 86 QYPLFRPPAQWSSLLGAAHSSDYSMWRK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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