AutismKB 2.0

Annotation Detail for PRMT5


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Basic Information Top
Gene Symbol:PRMT5 ( HRMT1L5,IBP72,JBP1,SKB1,SKB1Hs )
Gene Full Name: protein arginine methyltransferase 5
Band: 14q11.2
Quick LinksEntrez ID:10419; OMIM: 604045; Uniprot ID:ANM5_HUMAN; ENSEMBL ID: ENSG00000100462; HGNC ID: 10894
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst5 / 6231980
fetus96 / 564012170
neonate7 / 31097225
infant21 / 23620889
juvenile54 / 55556971
adult252 / 1939121129
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor14 / 94178148
cervical tumor7 / 34366203
chondrosarcoma6 / 8282372
colorectal tumor12 / 114246105
esophageal tumor7 / 17290404
gastrointestinal tumor71 / 119369594
germ cell tumor82 / 263845310
glioma30 / 106883280
head and neck tumor27 / 136302198
kidney tumor7 / 68959101
leukemia16 / 95842166
liver tumor44 / 96359456
lung tumor27 / 103127261
lymphoma19 / 71755264
non-neoplasia10 / 97250102
normal511 / 3360307152
ovarian tumor13 / 76682169
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS81 / 125680644
prostate cancer15 / 102680146
retinoblastoma12 / 46356258
skin tumor19 / 124949152
soft tissue/muscle tissue tumor35 / 125191279
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland9 / 33197271
ascites58 / 400151449
bladder4 / 29757134
blood19 / 123478153
bone2 / 7165527
bone marrow6 / 48801122
brain284 / 1100989257
cervix15 / 48171311
connective tissue24 / 149255160
ear0 / 162120 
embryonic tissue26 / 215722120
esophagus8 / 20209395
eye22 / 211054104
heart12 / 89626133
intestine41 / 234472174
kidney48 / 211777226
larynx0 / 241450 
liver59 / 207743284
lung47 / 336974139
lymph10 / 44270225
lymph node5 / 9161054
mammary gland21 / 153271137
mouth22 / 67052328
muscle20 / 107715185
nerve0 / 157680 
ovary16 / 102051156
pancreas11 / 21481251
parathyroid2 / 2053997
pharynx1 / 4132824
pituitary gland2 / 16585120
placenta32 / 280825113
prostate32 / 189345169
salivary gland1 / 2015549
skin35 / 210574166
spleen14 / 53952259
stomach10 / 96619103
testis84 / 330442254
thymus17 / 81131209
thyroid13 / 47473273
tonsil0 / 169990 
trachea6 / 52413114
umbilical cord2 / 13680146
uterus36 / 232878154
vascular20 / 51780386
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217786_at
Cell line Expression level Expression bar
721_B_lymphoblasts350.95
Adipocyte34.9
AdrenalCortex19.05
Adrenalgland26
Amygdala23.85
Appendix21.05
AtrioventricularNode15.4
BDCA4+_DentriticCells108
Bonemarrow22.25
BronchialEpithelialCells161.4
CD105+_Endothelial104.45
CD14+_Monocytes34.5
CD19+_BCells(neg._sel.)27.05
CD33+_Myeloid57.5
CD34+195.15
CD4+_Tcells27.55
CD56+_NKCells27.65
CD71+_EarlyErythroid22.55
CD8+_Tcells23
CardiacMyocytes38.3
Caudatenucleus19.6
Cerebellum19.35
CerebellumPeduncles23.95
CiliaryGanglion11.45
CingulateCortex21.05
Colorectaladenocarcinoma69.4
DorsalRootGanglion16.4
FetalThyroid22.45
Fetalbrain24
Fetalliver29.55
Fetallung30.85
GlobusPallidus16.35
Heart42.3
Hypothalamus27.3
Kidney35.1
Leukemia_chronicMyelogenousK-56253.35
Leukemia_promyelocytic-HL-60127.8
Leukemialymphoblastic(MOLT-4)62.9
Liver30.6
Lung25.9
Lymphnode19
Lymphoma_burkitts(Daudi)112
Lymphoma_burkitts(Raji)35.75
MedullaOblongata21.05
OccipitalLobe20.6
OlfactoryBulb17.15
Ovary15.25
Pancreas13.6
PancreaticIslet38.45
ParietalLobe21.15
Pituitary26.75
Placenta33.05
Pons21.5
PrefrontalCortex27.25
Prostate44.5
Salivarygland17.55
SkeletalMuscle25
Skin12.5
SmoothMuscle59.25
Spinalcord23.5
SubthalamicNucleus20.2
SuperiorCervicalGanglion24.3
TemporalLobe20.95
Testis47.15
TestisGermCell22.5
TestisIntersitial23.15
TestisLeydigCell23.3
TestisSeminiferousTubule18.85
Thalamus23.3
Thymus35.65
Thyroid62.05
Tongue17.75
Tonsil24.35
Trachea19.4
TrigeminalGanglion11.35
Uterus19.15
UterusCorpus20
WholeBlood32.1
Wholebrain44.25
colon23.7
pineal_day32.88
pineal_night30.72
retina49.2
small_intestine25.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P298420
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.93 ± 0.71
Basal Forebrain3.72 ± 0.48
Basal Part of Pons3.8 ± 0.4
Cerebellar Cortex3.86 ± 0.4
Cerebellar Nuclei3.69 ± 0.47
Claustrum3.96 ± 0.81
Epithalamus4.08 ± 0.55
Frontal Lobe3.95 ± 0.51
Globus Pallidus3.54 ± 0.61
Hypothalamus3.64 ± 0.6
Insula3.86 ± 0.79
Limbic Lobe3.96 ± 0.47
Mesencephalon4 ± 0.56
Myelencephalon3.84 ± 0.55
Occipital Lobe3.81 ± 0.54
Parietal Lobe3.91 ± 0.47
Pontine Tegmentum3.79 ± 0.55
Striatum3.78 ± 0.47
Subthalamus3.57 ± 0.83
Temporal Lobe3.86 ± 0.46
Thalamus3.81 ± 0.47
White Matter2.78 ± 0.7
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Prmt5CBCerebellum13
18.64
Prmt5CTXCerebral cortex16.05
13.56
Prmt5HIPHippocampal region24.77
30.86
Prmt5HPFHippocampal formation25.05
28.09
Prmt5HYHypothalamus5.17
4.97
Prmt5LSXLateral septal complex39.61
32.32
Prmt5MBMidbrain5.21
6.44
Prmt5MYMedulla8.41
12.43
Prmt5OLFOlfactory bulb10.84
9.24
Prmt5PPons5
9.08
Prmt5PALPallidum3.41
3.19
Prmt5RHPRetrohippocampal region25.82
24.87
Prmt5sAMYStriatum-like amygdalar nuclei3.15
2.85
Prmt5STRStriatum4.28
3.83
Prmt5STRdStriatum dorsal region2.92
2.92
Prmt5STRvStriatum ventral region8.25
5.89
Prmt5THThalamus10.12
9.67
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ANM5_HUMAN_1 12 1 12 AAMAVGGAGGSR PRIDE
ANM5_HUMAN_2 12 2 13 AAMAVGGAGGSR PRIDE
ANM5_HUMAN_348 20 348 367 VPEEEKDTNVQVLMVLGAGR PRIDE
ANM5_HUMAN_35 14 35 48 QGFDFLCMPVFHPR PRIDE
ANM5_HUMAN_488 17 488 504 EKDRDPEAQFEMPYVVR PRIDE
ANM5_HUMAN_490 15 490 504 DRDPEAQFEMPYVVR PRIDE
ANM5_HUMAN_492 13 492 504 DPEAQFEMPYVVR PRIDE
PAp00001163 11 344 354 CLLDRVPEEEK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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