AutismKB 2.0

Annotation Detail for PGRMC2


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Basic Information Top
Gene Symbol:PGRMC2 ( DG6,PMBP )
Gene Full Name: progesterone receptor membrane component 2
Band: 4q28.2
Quick LinksEntrez ID:10424; OMIM: 607735; Uniprot ID:; ENSEMBL ID: ENSG00000164040; HGNC ID: 16089
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body10 / 70761141
blastocyst6 / 6231996
fetus70 / 564012124
neonate4 / 31097128
infant3 / 23620127
juvenile4 / 5555671
adult195 / 1939121100
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor7 / 9417874
cervical tumor3 / 3436687
chondrosarcoma12 / 82823144
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor11 / 11936992
germ cell tumor9 / 26384534
glioma7 / 10688365
head and neck tumor7 / 13630251
kidney tumor8 / 68959116
leukemia6 / 9584262
liver tumor9 / 9635993
lung tumor3 / 10312729
lymphoma4 / 7175555
non-neoplasia14 / 97250143
normal333 / 336030799
ovarian tumor7 / 7668291
pancreatic tumor11 / 104616105
primitive neuroectodermal tumor of the CNS11 / 12568087
prostate cancer5 / 10268048
retinoblastoma1 / 4635621
skin tumor6 / 12494948
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder2 / 2975767
blood8 / 12347864
bone9 / 71655125
bone marrow3 / 4880161
brain64 / 110098958
cervix7 / 48171145
connective tissue14 / 14925593
ear2 / 16212123
embryonic tissue19 / 21572288
esophagus0 / 202090 
eye21 / 21105499
heart11 / 89626122
intestine11 / 23447246
kidney32 / 211777151
larynx1 / 2414541
liver23 / 207743110
lung19 / 33697456
lymph0 / 442700 
lymph node7 / 9161076
mammary gland17 / 153271110
mouth2 / 6705229
muscle5 / 10771546
nerve0 / 157680 
ovary7 / 10205168
pancreas20 / 21481293
parathyroid9 / 20539438
pharynx0 / 413280 
pituitary gland4 / 16585241
placenta63 / 280825224
prostate10 / 18934552
salivary gland0 / 201550 
skin31 / 210574147
spleen1 / 5395218
stomach14 / 96619144
testis28 / 33044284
thymus3 / 8113136
thyroid6 / 47473126
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord4 / 13680292
uterus10 / 23287842
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213227_at
Cell line Expression level Expression bar
721_B_lymphoblasts32.25
Adipocyte102.35
AdrenalCortex53.95
Adrenalgland36.6
Amygdala182.8
Appendix79.65
AtrioventricularNode27.7
BDCA4+_DentriticCells32.8
Bonemarrow31.55
BronchialEpithelialCells28.15
CD105+_Endothelial165.95
CD14+_Monocytes34.45
CD19+_BCells(neg._sel.)32.55
CD33+_Myeloid34.75
CD34+61.9
CD4+_Tcells32.3
CD56+_NKCells67.3
CD71+_EarlyErythroid258.85
CD8+_Tcells29.25
CardiacMyocytes61.35
Caudatenucleus71.15
Cerebellum81.35
CerebellumPeduncles53.6
CiliaryGanglion33.7
CingulateCortex47.6
Colorectaladenocarcinoma29.6
DorsalRootGanglion46.6
FetalThyroid51.4
Fetalbrain71.35
Fetalliver130.25
Fetallung36.1
GlobusPallidus40.5
Heart43.1
Hypothalamus155.65
Kidney34.65
Leukemia_chronicMyelogenousK-56226.2
Leukemia_promyelocytic-HL-6026.3
Leukemialymphoblastic(MOLT-4)27.75
Liver49.2
Lung32.45
Lymphnode29.75
Lymphoma_burkitts(Daudi)43.15
Lymphoma_burkitts(Raji)55.5
MedullaOblongata85
OccipitalLobe69.05
OlfactoryBulb42.05
Ovary29.5
Pancreas34.55
PancreaticIslet53.1
ParietalLobe44.35
Pituitary185.35
Placenta98.6
Pons59
PrefrontalCortex112.15
Prostate78.45
Salivarygland35.2
SkeletalMuscle57.75
Skin33.95
SmoothMuscle35.1
Spinalcord77.45
SubthalamicNucleus33.6
SuperiorCervicalGanglion92.7
TemporalLobe56.65
Testis38.85
TestisGermCell25.05
TestisIntersitial27.9
TestisLeydigCell32.45
TestisSeminiferousTubule31.6
Thalamus73.55
Thymus20.9
Thyroid248.1
Tongue43.25
Tonsil31.05
Trachea33.1
TrigeminalGanglion39.9
Uterus56.8
UterusCorpus55.55
WholeBlood32.05
Wholebrain86.5
colon95.2
pineal_day278.36
pineal_night244.52
retina189.95
small_intestine107.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P155868
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10 ± 0.27
Basal Forebrain9.99 ± 0.26
Basal Part of Pons9.69 ± 0.29
Cerebellar Cortex9.71 ± 0.32
Cerebellar Nuclei10.03 ± 0.2
Claustrum10.24 ± 0.42
Epithalamus9.94 ± 0.23
Frontal Lobe9.78 ± 0.29
Globus Pallidus10.17 ± 0.08
Hypothalamus10.23 ± 0.24
Insula9.79 ± 0.27
Limbic Lobe9.93 ± 0.34
Mesencephalon10.06 ± 0.28
Myelencephalon9.91 ± 0.26
Occipital Lobe10.12 ± 0.3
Parietal Lobe9.94 ± 0.29
Pontine Tegmentum9.94 ± 0.28
Striatum10.01 ± 0.26
Subthalamus10.22 ± 0.07
Temporal Lobe9.83 ± 0.26
Thalamus9.83 ± 0.22
White Matter10.2 ± 0.42
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Pgrmc2CBCerebellum28.45
40.36
Pgrmc2CTXCerebral cortex67
42.86
Pgrmc2HIPHippocampal region40.82
59.67
Pgrmc2HPFHippocampal formation50.87
51.89
Pgrmc2HYHypothalamus55.86
37.75
Pgrmc2LSXLateral septal complex34.02
17.53
Pgrmc2MBMidbrain39.09
30.63
Pgrmc2MYMedulla49.44
49.78
Pgrmc2OLFOlfactory bulb55.31
37.74
Pgrmc2PPons47.83
43.61
Pgrmc2PALPallidum43.03
32.41
Pgrmc2RHPRetrohippocampal region63.7
43.31
Pgrmc2sAMYStriatum-like amygdalar nuclei57.7
33.78
Pgrmc2STRStriatum44.57
25.95
Pgrmc2STRdStriatum dorsal region48.01
28.83
Pgrmc2STRvStriatum ventral region33.49
19.12
Pgrmc2THThalamus24.92
15.82
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PGRC2_HUMAN_0 0 0 0 FYGPAGPYGIFAGR PRIDE
PGRC2_HUMAN_101 8 101 108 DFSLEQLR PRIDE
PGRC2_HUMAN_102 8 102 109 DFSLEQLR PRIDE
PGRC2_HUMAN_135 14 135 148 FYGPAGPYGIFAGR PRIDE
PGRC2_HUMAN_136 14 136 149 FYGPAGPYGIFAGR PRIDE
PGRC2_HUMAN_153 9 153 161 GLATFCLDK PRIDE
PGRC2_HUMAN_185 7 185 191 EWEMQFK PRIDE
PGRC2_HUMAN_77 20 77 96 RGLGAGAGAGEESPATSLPR PRIDE
PGRC2_HUMAN_78 19 78 96 GLGAGAGAGEESPATSLPR PRIDE
PGRC2_HUMAN_79 19 79 97 GLGAGAGAGEESPATSLPR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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