AutismKB 2.0

Annotation Detail for VAV3


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Basic Information Top
Gene Symbol:VAV3 ( FLJ40431 )
Gene Full Name: vav 3 guanine nucleotide exchange factor
Band: 1p13.3
Quick LinksEntrez ID:10451; OMIM: 605541; Uniprot ID:VAV3_HUMAN; ENSEMBL ID: ENSG00000134215; HGNC ID: 12659
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst2 / 6231932
fetus12 / 56401221
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult49 / 193912125
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor1 / 1729057
gastrointestinal tumor1 / 1193698
germ cell tumor7 / 26384526
glioma0 / 1068830 
head and neck tumor10 / 13630273
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia7 / 9725071
normal81 / 336030724
ovarian tumor2 / 7668226
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder2 / 2975767
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain15 / 110098913
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus1 / 2020949
eye6 / 21105428
heart2 / 8962622
intestine8 / 23447234
kidney11 / 21177751
larynx0 / 241450 
liver5 / 20774324
lung1 / 3369742
lymph0 / 442700 
lymph node3 / 9161032
mammary gland6 / 15327139
mouth10 / 67052149
muscle3 / 10771527
nerve0 / 157680 
ovary2 / 10205119
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta22 / 28082578
prostate1 / 1893455
salivary gland0 / 201550 
skin4 / 21057418
spleen0 / 539520 
stomach0 / 966190 
testis7 / 33044221
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea8 / 52413152
umbilical cord0 / 136800 
uterus9 / 23287838
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218807_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.6
Adipocyte6.7
AdrenalCortex7.65
Adrenalgland5.8
Amygdala8.9
Appendix9.45
AtrioventricularNode5.5
BDCA4+_DentriticCells14.65
Bonemarrow7.1
BronchialEpithelialCells8.4
CD105+_Endothelial6.85
CD14+_Monocytes15.35
CD19+_BCells(neg._sel.)86.75
CD33+_Myeloid11.25
CD34+39.85
CD4+_Tcells7.35
CD56+_NKCells84.45
CD71+_EarlyErythroid6.25
CD8+_Tcells8.9
CardiacMyocytes9.55
Caudatenucleus6.25
Cerebellum13.5
CerebellumPeduncles8.25
CiliaryGanglion5.9
CingulateCortex8.65
Colorectaladenocarcinoma6.85
DorsalRootGanglion6.9
FetalThyroid6.8
Fetalbrain6.95
Fetalliver5.95
Fetallung5.55
GlobusPallidus5.25
Heart9.25
Hypothalamus9.8
Kidney78.85
Leukemia_chronicMyelogenousK-5626.1
Leukemia_promyelocytic-HL-605.9
Leukemialymphoblastic(MOLT-4)19.6
Liver9
Lung7.6
Lymphnode10.65
Lymphoma_burkitts(Daudi)9.4
Lymphoma_burkitts(Raji)10.2
MedullaOblongata7.05
OccipitalLobe6.2
OlfactoryBulb5.5
Ovary5.3
Pancreas11.55
PancreaticIslet7.3
ParietalLobe7.55
Pituitary8.1
Placenta190.75
Pons6.6
PrefrontalCortex8.5
Prostate12.45
Salivarygland5.65
SkeletalMuscle8.95
Skin14.7
SmoothMuscle7.35
Spinalcord7.2
SubthalamicNucleus6.3
SuperiorCervicalGanglion12.15
TemporalLobe6.45
Testis6.05
TestisGermCell5.9
TestisIntersitial5.7
TestisLeydigCell6.95
TestisSeminiferousTubule6.45
Thalamus10.8
Thymus5.7
Thyroid11.05
Tongue97.65
Tonsil10.25
Trachea7.25
TrigeminalGanglion7.7
Uterus6.45
UterusCorpus10.9
WholeBlood42.95
Wholebrain6
colon84.1
pineal_day8.12
pineal_night8.04
retina8.925
small_intestine10.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P201551
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.35 ± 0.39
Basal Forebrain6.96 ± 0.26
Basal Part of Pons7.92 ± 0.24
Cerebellar Cortex7.64 ± 0.27
Cerebellar Nuclei8.06 ± 0.45
Claustrum5.78 ± 1.03
Epithalamus6.41 ± 2.22
Frontal Lobe6.95 ± 0.76
Globus Pallidus7.77 ± 0.64
Hypothalamus6.93 ± 0.62
Insula6.87 ± 0.56
Limbic Lobe6.37 ± 0.69
Mesencephalon7.39 ± 0.97
Myelencephalon7 ± 1.08
Occipital Lobe8.32 ± 0.86
Parietal Lobe7.55 ± 0.88
Pontine Tegmentum6.97 ± 0.86
Striatum6.13 ± 0.96
Subthalamus7.4 ± 0.16
Temporal Lobe6.93 ± 0.7
Thalamus8.11 ± 0.87
White Matter2.94 ± 0.76
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Vav3CBCerebellum32.38
50.2
Vav3CTXCerebral cortex14.3
9.64
Vav3HIPHippocampal region10.89
14.15
Vav3HPFHippocampal formation10.73
11.42
Vav3HYHypothalamus11.51
8.82
Vav3LSXLateral septal complex5.08
3.25
Vav3MBMidbrain13.3
12.18
Vav3MYMedulla16.51
16.94
Vav3OLFOlfactory bulb15.51
12.4
Vav3PPons13.57
14.09
Vav3PALPallidum11.29
9.34
Vav3RHPRetrohippocampal region10.43
7.32
Vav3sAMYStriatum-like amygdalar nuclei14.39
9.7
Vav3STRStriatum13.7
9.63
Vav3STRdStriatum dorsal region13.59
9.89
Vav3STRvStriatum ventral region14.99
9.53
Vav3THThalamus51.63
41.27
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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