AutismKB 2.0

Annotation Detail for UBE2E3


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Basic Information Top
Gene Symbol:UBE2E3 ( UBCH9,UbcM2 )
Gene Full Name: ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
Band: 2q31.3
Quick LinksEntrez ID:10477; OMIM: 604151; Uniprot ID:UB2E3_HUMAN; ENSEMBL ID: ENSG00000170035; HGNC ID: 12479
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body11 / 70761155
blastocyst9 / 62319144
fetus52 / 56401292
neonate0 / 310970 
infant2 / 2362084
juvenile3 / 5555653
adult158 / 193912181
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor0 / 941780 
cervical tumor2 / 3436658
chondrosarcoma10 / 82823120
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor10 / 11936983
germ cell tumor9 / 26384534
glioma14 / 106883130
head and neck tumor10 / 13630273
kidney tumor5 / 6895972
leukemia4 / 9584241
liver tumor8 / 9635983
lung tumor7 / 10312767
lymphoma2 / 7175527
non-neoplasia4 / 9725041
normal196 / 336030758
ovarian tumor1 / 7668213
pancreatic tumor17 / 104616162
primitive neuroectodermal tumor of the CNS13 / 125680103
prostate cancer5 / 10268048
retinoblastoma9 / 46356194
skin tumor12 / 12494996
soft tissue/muscle tissue tumor70 / 125191559
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder3 / 29757100
blood4 / 12347832
bone7 / 7165597
bone marrow2 / 4880140
brain57 / 110098951
cervix5 / 48171103
connective tissue73 / 149255489
ear2 / 16212123
embryonic tissue31 / 215722143
esophagus0 / 202090 
eye26 / 211054123
heart20 / 89626223
intestine10 / 23447242
kidney9 / 21177742
larynx1 / 2414541
liver11 / 20774352
lung35 / 336974103
lymph1 / 4427022
lymph node12 / 91610130
mammary gland0 / 1532710 
mouth2 / 6705229
muscle5 / 10771546
nerve3 / 15768190
ovary1 / 1020519
pancreas22 / 214812102
parathyroid5 / 20539243
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta6 / 28082521
prostate8 / 18934542
salivary gland7 / 20155347
skin17 / 21057480
spleen1 / 5395218
stomach7 / 9661972
testis16 / 33044248
thymus1 / 8113112
thyroid1 / 4747321
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus14 / 23287860
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210024_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts219.95
Adipocyte226.85
AdrenalCortex23.3
Adrenalgland78.4
Amygdala485.8
Appendix20.8
AtrioventricularNode17.25
BDCA4+_DentriticCells553.75
Bonemarrow91.95
BronchialEpithelialCells212.1
CD105+_Endothelial471.55
CD14+_Monocytes235.1
CD19+_BCells(neg._sel.)183.85
CD33+_Myeloid243.75
CD34+358.45
CD4+_Tcells104.1
CD56+_NKCells519.4
CD71+_EarlyErythroid541.7
CD8+_Tcells137.45
CardiacMyocytes158.2
Caudatenucleus88.5
Cerebellum179.85
CerebellumPeduncles146.75
CiliaryGanglion12.4
CingulateCortex114.85
Colorectaladenocarcinoma472.25
DorsalRootGanglion56.15
FetalThyroid112.8
Fetalbrain524.6
Fetalliver182.4
Fetallung151.2
GlobusPallidus52.8
Heart94.3
Hypothalamus250.9
Kidney124.3
Leukemia_chronicMyelogenousK-562190.9
Leukemia_promyelocytic-HL-6010.75
Leukemialymphoblastic(MOLT-4)203.8
Liver58.95
Lung230.4
Lymphnode50.2
Lymphoma_burkitts(Daudi)119.85
Lymphoma_burkitts(Raji)20.15
MedullaOblongata102.9
OccipitalLobe226.55
OlfactoryBulb124.4
Ovary14.7
Pancreas57.45
PancreaticIslet116.6
ParietalLobe112.65
Pituitary96.8
Placenta221.6
Pons46.7
PrefrontalCortex251.9
Prostate159.85
Salivarygland93.35
SkeletalMuscle32.4
Skin37.3
SmoothMuscle226.85
Spinalcord126.95
SubthalamicNucleus96.2
SuperiorCervicalGanglion20.15
TemporalLobe84.25
Testis310.2
TestisGermCell183.9
TestisIntersitial78.35
TestisLeydigCell66.9
TestisSeminiferousTubule54.65
Thalamus114.9
Thymus210.5
Thyroid629.05
Tongue34.4
Tonsil46.1
Trachea97.95
TrigeminalGanglion11.75
Uterus118.25
UterusCorpus14.2
WholeBlood146.85
Wholebrain409.85
colon298.5
pineal_day921.64
pineal_night1020.56
retina364.15
small_intestine261.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P148450
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.16 ± 0.74
Basal Forebrain5.13 ± 0.4
Basal Part of Pons5.59 ± 0.72
Cerebellar Cortex6.02 ± 0.38
Cerebellar Nuclei4.82 ± 0.53
Claustrum4.7 ± 0.9
Epithalamus5.8 ± 0.37
Frontal Lobe5.79 ± 0.56
Globus Pallidus4.81 ± 0.28
Hypothalamus5.78 ± 0.56
Insula5.87 ± 0.4
Limbic Lobe5.48 ± 0.79
Mesencephalon5.38 ± 0.63
Myelencephalon5.47 ± 0.68
Occipital Lobe4.93 ± 0.66
Parietal Lobe5.57 ± 0.56
Pontine Tegmentum5.56 ± 0.63
Striatum4.63 ± 0.55
Subthalamus5.22 ± 0.37
Temporal Lobe5.77 ± 0.55
Thalamus5.41 ± 0.59
White Matter5.38 ± 0.48
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ube2e3CBCerebellum1.57
2.24
Ube2e3CTXCerebral cortex8.55
4.38
Ube2e3HIPHippocampal region6.37
5.25
Ube2e3HPFHippocampal formation9.1
6.92
Ube2e3HYHypothalamus1.48
0.65
Ube2e3LSXLateral septal complex2.27
0.92
Ube2e3MBMidbrain2.24
2.04
Ube2e3MYMedulla3.72
3.04
Ube2e3OLFOlfactory bulb23.56
13.11
Ube2e3PPons2.13
1.02
Ube2e3PALPallidum0.82
0.55
Ube2e3RHPRetrohippocampal region13.15
8.79
Ube2e3sAMYStriatum-like amygdalar nuclei1.35
0.56
Ube2e3STRStriatum0.86
0.5
Ube2e3STRdStriatum dorsal region0.43
0.38
Ube2e3STRvStriatum ventral region1.51
0.71
Ube2e3THThalamus7.95
4.59
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00015679 18 133 150 IYHCNINSQGVICLDILK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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