AutismKB 2.0

Annotation Detail for SEC23B


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Basic Information Top
Gene Symbol:SEC23B ( CDA-II,CDAII,CDAN2,HEMPAS )
Gene Full Name: Sec23 homolog B (S. cerevisiae)
Band: 20p11.23
Quick LinksEntrez ID:10483; OMIM: 224100,610512; Uniprot ID:SC23B_HUMAN; ENSEMBL ID: ENSG00000101310; HGNC ID: 10702
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst9 / 62319144
fetus75 / 564012132
neonate2 / 3109764
infant2 / 2362084
juvenile6 / 55556107
adult209 / 1939121107
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma1 / 1747557
breast (mammary gland) tumor4 / 9417842
cervical tumor3 / 3436687
chondrosarcoma9 / 82823108
colorectal tumor12 / 114246105
esophageal tumor1 / 1729057
gastrointestinal tumor11 / 11936992
germ cell tumor53 / 263845200
glioma22 / 106883205
head and neck tumor24 / 136302176
kidney tumor5 / 6895972
leukemia14 / 95842146
liver tumor6 / 9635962
lung tumor6 / 10312758
lymphoma2 / 7175527
non-neoplasia8 / 9725082
normal393 / 3360307116
ovarian tumor0 / 766820 
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer6 / 10268058
retinoblastoma5 / 46356107
skin tumor19 / 124949152
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland4 / 33197120
ascites6 / 40015149
bladder5 / 29757168
blood22 / 123478178
bone6 / 7165583
bone marrow1 / 4880120
brain163 / 1100989148
cervix3 / 4817162
connective tissue14 / 14925593
ear1 / 1621261
embryonic tissue16 / 21572274
esophagus1 / 2020949
eye15 / 21105471
heart9 / 89626100
intestine18 / 23447276
kidney29 / 211777136
larynx1 / 2414541
liver10 / 20774348
lung21 / 33697462
lymph1 / 4427022
lymph node5 / 9161054
mammary gland6 / 15327139
mouth24 / 67052357
muscle9 / 10771583
nerve3 / 15768190
ovary2 / 10205119
pancreas19 / 21481288
parathyroid3 / 20539146
pharynx9 / 41328217
pituitary gland4 / 16585241
placenta34 / 280825121
prostate33 / 189345174
salivary gland0 / 201550 
skin25 / 210574118
spleen9 / 53952166
stomach10 / 96619103
testis76 / 330442229
thymus10 / 81131123
thyroid4 / 4747384
tonsil0 / 169990 
trachea18 / 52413343
umbilical cord0 / 136800 
uterus16 / 23287868
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201582_at
Cell line Expression level Expression bar
721_B_lymphoblasts10.7
Adipocyte5.5
AdrenalCortex6.35
Adrenalgland9.1
Amygdala6.55
Appendix11.05
AtrioventricularNode5.1
BDCA4+_DentriticCells12.7
Bonemarrow5.95
BronchialEpithelialCells5.85
CD105+_Endothelial5.8
CD14+_Monocytes8.55
CD19+_BCells(neg._sel.)5.95
CD33+_Myeloid25.2
CD34+7.85
CD4+_Tcells6.15
CD56+_NKCells10.35
CD71+_EarlyErythroid5.15
CD8+_Tcells5.45
CardiacMyocytes7.65
Caudatenucleus5.6
Cerebellum4.75
CerebellumPeduncles6.7
CiliaryGanglion7.75
CingulateCortex6
Colorectaladenocarcinoma5.7
DorsalRootGanglion4.95
FetalThyroid5.7
Fetalbrain6.6
Fetalliver7.9
Fetallung4.7
GlobusPallidus4.3
Heart8.05
Hypothalamus6.65
Kidney5.25
Leukemia_chronicMyelogenousK-5625.15
Leukemia_promyelocytic-HL-605.1
Leukemialymphoblastic(MOLT-4)4.75
Liver7.75
Lung6.35
Lymphnode5.1
Lymphoma_burkitts(Daudi)7.25
Lymphoma_burkitts(Raji)8.25
MedullaOblongata9.25
OccipitalLobe5.2
OlfactoryBulb4.55
Ovary4.05
Pancreas4.75
PancreaticIslet6.4
ParietalLobe6.25
Pituitary9.1
Placenta5.75
Pons5.55
PrefrontalCortex7.45
Prostate7.25
Salivarygland6.55
SkeletalMuscle7.15
Skin4.7
SmoothMuscle6.4
Spinalcord9.1
SubthalamicNucleus5.4
SuperiorCervicalGanglion17.6
TemporalLobe5.25
Testis5.05
TestisGermCell4.5
TestisIntersitial4.65
TestisLeydigCell5.75
TestisSeminiferousTubule4.85
Thalamus6
Thymus4.65
Thyroid11.55
Tongue5.8
Tonsil5.65
Trachea7.4
TrigeminalGanglion6.2
Uterus4.6
UterusCorpus5.35
WholeBlood7.3
Wholebrain5.15
colon7.8
pineal_day16.56
pineal_night13.1
retina7.45
small_intestine6.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P6119
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.79 ± 0.71
Basal Forebrain3.34 ± 0.53
Basal Part of Pons4.22 ± 0.51
Cerebellar Cortex4.27 ± 0.43
Cerebellar Nuclei3.93 ± 0.46
Claustrum3.52 ± 0.65
Epithalamus4.26 ± 0.66
Frontal Lobe3.99 ± 0.55
Globus Pallidus3.96 ± 0.46
Hypothalamus3.8 ± 0.59
Insula4.08 ± 0.51
Limbic Lobe3.79 ± 0.58
Mesencephalon3.9 ± 0.67
Myelencephalon3.83 ± 0.56
Occipital Lobe3.65 ± 0.63
Parietal Lobe3.87 ± 0.61
Pontine Tegmentum3.94 ± 0.62
Striatum3.89 ± 0.51
Subthalamus4.05 ± 0.15
Temporal Lobe3.93 ± 0.66
Thalamus3.91 ± 0.57
White Matter4.89 ± 0.47
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Sec23bCBCerebellum15.32
24.7
Sec23bCTXCerebral cortex70.9
55.57
Sec23bHIPHippocampal region41.98
61.04
Sec23bHPFHippocampal formation56.55
64.01
Sec23bHYHypothalamus15.88
14.23
Sec23bLSXLateral septal complex9.03
5.64
Sec23bMBMidbrain17.23
17.8
Sec23bMYMedulla19.62
24.33
Sec23bOLFOlfactory bulb56.2
47.44
Sec23bPPons24.69
28.08
Sec23bPALPallidum36.94
37.56
Sec23bRHPRetrohippocampal region82.86
69.96
Sec23bsAMYStriatum-like amygdalar nuclei63.64
48.33
Sec23bSTRStriatum41.41
31.19
Sec23bSTRdStriatum dorsal region39.88
30.64
Sec23bSTRvStriatum ventral region40.49
28.33
Sec23bTHThalamus38.5
35.07
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000783 12 68 79 AVLNPLCQVDYR Peptide Atlas
SC23B_HUMAN_2 13 2 14 ATYLEFIQQNEER PRIDE
SC23B_HUMAN_218 13 218 230 PAQPQEHPFASSR PRIDE
SC23B_HUMAN_64 16 64 79 PTCKAVLNPLCQVDYR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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