AutismKB 2.0

Annotation Detail for UNC13B


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Basic Information Top
Gene Symbol:UNC13B ( MGC133279,MGC133280,MUNC13,UNC13,Unc13h2,hmunc13 )
Gene Full Name: unc-13 homolog B (C. elegans)
Band: 9p13.3
Quick LinksEntrez ID:10497; OMIM: 605836; Uniprot ID:UN13B_HUMAN; ENSEMBL ID: ENSG00000198722; HGNC ID: 12566
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst6 / 6231996
fetus39 / 56401269
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult123 / 193912163
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor3 / 3436687
chondrosarcoma2 / 8282324
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor8 / 11936967
germ cell tumor4 / 26384515
glioma14 / 106883130
head and neck tumor6 / 13630244
kidney tumor4 / 6895958
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor8 / 10312777
lymphoma0 / 717550 
non-neoplasia6 / 9725061
normal209 / 336030762
ovarian tumor0 / 766820 
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer4 / 10268038
retinoblastoma3 / 4635664
skin tumor6 / 12494948
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland3 / 3319790
ascites0 / 400150 
bladder1 / 2975733
blood0 / 1234780 
bone2 / 7165527
bone marrow2 / 4880140
brain65 / 110098959
cervix3 / 4817162
connective tissue2 / 14925513
ear1 / 1621261
embryonic tissue15 / 21572269
esophagus0 / 202090 
eye10 / 21105447
heart4 / 8962644
intestine13 / 23447255
kidney7 / 21177733
larynx0 / 241450 
liver4 / 20774319
lung28 / 33697483
lymph0 / 442700 
lymph node1 / 9161010
mammary gland10 / 15327165
mouth4 / 6705259
muscle7 / 10771564
nerve2 / 15768126
ovary0 / 1020510 
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta5 / 28082517
prostate7 / 18934536
salivary gland0 / 201550 
skin53 / 210574251
spleen0 / 539520 
stomach7 / 9661972
testis20 / 33044260
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord4 / 13680292
uterus4 / 23287817
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202893_at
Cell line Expression level Expression bar
721_B_lymphoblasts12.75
Adipocyte15.85
AdrenalCortex10.9
Adrenalgland7.7
Amygdala16.6
Appendix12.95
AtrioventricularNode14.3
BDCA4+_DentriticCells5.1
Bonemarrow8.7
BronchialEpithelialCells9.35
CD105+_Endothelial8.3
CD14+_Monocytes6.4
CD19+_BCells(neg._sel.)5.35
CD33+_Myeloid8.05
CD34+11.55
CD4+_Tcells6.2
CD56+_NKCells5.9
CD71+_EarlyErythroid8.45
CD8+_Tcells5.25
CardiacMyocytes12.8
Caudatenucleus14.5
Cerebellum7.75
CerebellumPeduncles9.9
CiliaryGanglion9.85
CingulateCortex17.1
Colorectaladenocarcinoma8.4
DorsalRootGanglion7.25
FetalThyroid12.65
Fetalbrain9.75
Fetalliver8.3
Fetallung64.5
GlobusPallidus8.7
Heart8.8
Hypothalamus10.75
Kidney16.45
Leukemia_chronicMyelogenousK-5628.65
Leukemia_promyelocytic-HL-607.15
Leukemialymphoblastic(MOLT-4)7.55
Liver12
Lung42.8
Lymphnode7.7
Lymphoma_burkitts(Daudi)12.05
Lymphoma_burkitts(Raji)8.15
MedullaOblongata14.45
OccipitalLobe14.45
OlfactoryBulb14.45
Ovary6.7
Pancreas23.7
PancreaticIslet35
ParietalLobe12.55
Pituitary13.35
Placenta9.4
Pons20.4
PrefrontalCortex60.65
Prostate35.7
Salivarygland16.75
SkeletalMuscle18.95
Skin9.55
SmoothMuscle10.4
Spinalcord14.95
SubthalamicNucleus17.7
SuperiorCervicalGanglion22.8
TemporalLobe13.75
Testis28.15
TestisGermCell30.95
TestisIntersitial14.95
TestisLeydigCell10.3
TestisSeminiferousTubule16.9
Thalamus12.9
Thymus5.6
Thyroid11.95
Tongue9.5
Tonsil9.25
Trachea9.95
TrigeminalGanglion14.65
Uterus8
UterusCorpus9.15
WholeBlood5.95
Wholebrain26.3
colon20.45
pineal_day903.2
pineal_night852.42
retina82.825
small_intestine9.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13033_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.11 ± 0.33
Basal Forebrain4.86 ± 0.36
Basal Part of Pons4.45 ± 0.48
Cerebellar Cortex4.29 ± 0.38
Cerebellar Nuclei4.4 ± 0.4
Claustrum5.54 ± 0.6
Epithalamus4.37 ± 0.56
Frontal Lobe4.4 ± 0.44
Globus Pallidus4.29 ± 0.43
Hypothalamus4.49 ± 0.52
Insula4.56 ± 0.49
Limbic Lobe4.89 ± 0.55
Mesencephalon4.72 ± 0.61
Myelencephalon4.74 ± 0.52
Occipital Lobe5.35 ± 0.55
Parietal Lobe4.75 ± 0.47
Pontine Tegmentum4.74 ± 0.58
Striatum5.07 ± 0.42
Subthalamus4.28 ± 0.49
Temporal Lobe4.86 ± 0.33
Thalamus4.48 ± 0.56
White Matter4.06 ± 0.81
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Unc13bCBCerebellum14.92
17.31
Unc13bCTXCerebral cortex86.05
61.9
Unc13bHIPHippocampal region32.43
42.72
Unc13bHPFHippocampal formation45.14
46.83
Unc13bHYHypothalamus9.57
6.67
Unc13bLSXLateral septal complex3.53
3.26
Unc13bMBMidbrain14.54
11.02
Unc13bMYMedulla5.68
4.98
Unc13bOLFOlfactory bulb52.65
45.25
Unc13bPPons5.36
4.75
Unc13bPALPallidum9.22
7.53
Unc13bRHPRetrohippocampal region74.82
58.33
Unc13bsAMYStriatum-like amygdalar nuclei24.58
18.92
Unc13bSTRStriatum7.68
5.7
Unc13bSTRdStriatum dorsal region4.57
3.35
Unc13bSTRvStriatum ventral region6.46
3.85
Unc13bTHThalamus23.69
17.81
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00043275 13 1017 1029 YALEEHEKDHLCK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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