AutismKB 2.0

Annotation Detail for SEMA4D


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Basic Information Top
Gene Symbol:SEMA4D ( C9orf164,CD100,FLJ33485,FLJ34282,FLJ39737,FLJ46484,M-sema-G,MGC169138,MGC169141,SEMAJ,coll-4 )
Gene Full Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Band: 9q22.2
Quick LinksEntrez ID:10507; OMIM: 601866; Uniprot ID:SEM4D_HUMAN; ENSEMBL ID: ENSG00000187764; HGNC ID: 10732
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst3 / 6231948
fetus17 / 56401230
neonate0 / 310970 
infant1 / 2362042
juvenile6 / 55556107
adult102 / 193912152
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor9 / 26384534
glioma4 / 10688337
head and neck tumor5 / 13630236
kidney tumor1 / 6895914
leukemia10 / 95842104
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia11 / 97250113
normal171 / 336030750
ovarian tumor2 / 7668226
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer5 / 10268048
retinoblastoma2 / 4635643
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood18 / 123478145
bone0 / 716550 
bone marrow2 / 4880140
brain72 / 110098965
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye7 / 21105433
heart0 / 896260 
intestine7 / 23447229
kidney7 / 21177733
larynx3 / 24145124
liver1 / 2077434
lung13 / 33697438
lymph0 / 442700 
lymph node21 / 91610229
mammary gland4 / 15327126
mouth0 / 670520 
muscle4 / 10771537
nerve2 / 15768126
ovary2 / 10205119
pancreas7 / 21481232
parathyroid3 / 20539146
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta4 / 28082514
prostate16 / 18934584
salivary gland0 / 201550 
skin3 / 21057414
spleen1 / 5395218
stomach0 / 966190 
testis8 / 33044224
thymus7 / 8113186
thyroid3 / 4747363
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus12 / 23287851
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203528_at
Cell line Expression level Expression bar
721_B_lymphoblasts275.95
Adipocyte12.8
AdrenalCortex15
Adrenalgland19.4
Amygdala44.95
Appendix16.5
AtrioventricularNode6.9
BDCA4+_DentriticCells291.25
Bonemarrow126.5
BronchialEpithelialCells12.6
CD105+_Endothelial56.9
CD14+_Monocytes431.6
CD19+_BCells(neg._sel.)43.7
CD33+_Myeloid1048.2
CD34+492.95
CD4+_Tcells1437.8
CD56+_NKCells1598.5
CD71+_EarlyErythroid17.95
CD8+_Tcells1613.7
CardiacMyocytes18.05
Caudatenucleus30.45
Cerebellum14.65
CerebellumPeduncles18.15
CiliaryGanglion10.2
CingulateCortex34.55
Colorectaladenocarcinoma39.95
DorsalRootGanglion8.05
FetalThyroid16.1
Fetalbrain16.35
Fetalliver13.8
Fetallung12.35
GlobusPallidus12.05
Heart19.45
Hypothalamus153.35
Kidney20.25
Leukemia_chronicMyelogenousK-56214.3
Leukemia_promyelocytic-HL-6012.95
Leukemialymphoblastic(MOLT-4)447.2
Liver21.45
Lung82.45
Lymphnode238.3
Lymphoma_burkitts(Daudi)162.6
Lymphoma_burkitts(Raji)105.85
MedullaOblongata71.5
OccipitalLobe46.8
OlfactoryBulb29.1
Ovary9.35
Pancreas12.3
PancreaticIslet17.05
ParietalLobe57.5
Pituitary16.8
Placenta15.7
Pons17.7
PrefrontalCortex35.1
Prostate54.8
Salivarygland22.4
SkeletalMuscle19.95
Skin11.55
SmoothMuscle14.45
Spinalcord119
SubthalamicNucleus27.75
SuperiorCervicalGanglion16.75
TemporalLobe13.7
Testis24.35
TestisGermCell21.35
TestisIntersitial12.3
TestisLeydigCell14.85
TestisSeminiferousTubule13.85
Thalamus44.25
Thymus344.55
Thyroid21.15
Tongue28.1
Tonsil104.55
Trachea15.8
TrigeminalGanglion14.75
Uterus18.35
UterusCorpus13.7
WholeBlood1107.9
Wholebrain80.7
colon18.4
pineal_day14.62
pineal_night13.68
retina69.9
small_intestine23.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P261169
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.17 ± 0.77
Basal Forebrain2.8 ± 0.45
Basal Part of Pons3.08 ± 0.58
Cerebellar Cortex2.84 ± 0.56
Cerebellar Nuclei3.34 ± 0.53
Claustrum3.51 ± 0.66
Epithalamus3.33 ± 0.97
Frontal Lobe3.28 ± 0.64
Globus Pallidus4.04 ± 0.47
Hypothalamus3.33 ± 0.82
Insula3.38 ± 0.52
Limbic Lobe2.94 ± 0.75
Mesencephalon3.31 ± 0.82
Myelencephalon3.12 ± 0.7
Occipital Lobe3 ± 0.66
Parietal Lobe3.04 ± 0.77
Pontine Tegmentum3.24 ± 0.73
Striatum2.84 ± 0.77
Subthalamus3.33 ± 0.36
Temporal Lobe3.13 ± 0.69
Thalamus3.3 ± 0.66
White Matter5.06 ± 0.4
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Sema4dCBCerebellum0.72
0.93
Sema4dCTXCerebral cortex0.61
0.66
Sema4dHIPHippocampal region0.59
0.68
Sema4dHPFHippocampal formation0.57
0.61
Sema4dHYHypothalamus0.69
0.8
Sema4dLSXLateral septal complex0.58
0.57
Sema4dMBMidbrain0.84
1.07
Sema4dMYMedulla0.82
0.91
Sema4dOLFOlfactory bulb2.3
1.58
Sema4dPPons0.9
1.15
Sema4dPALPallidum1.11
1.29
Sema4dRHPRetrohippocampal region0.51
0.48
Sema4dsAMYStriatum-like amygdalar nuclei0.58
0.63
Sema4dSTRStriatum0.72
0.76
Sema4dSTRdStriatum dorsal region0.77
0.84
Sema4dSTRvStriatum ventral region0.66
0.65
Sema4dTHThalamus0.99
1.06
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00039416 31 451 481 AISLEHAVHIIEETQLFQDFEPVQTLLLSSK Peptide Atlas
SEM4D_HUMAN_367 10 367 376 PGACIDSEAR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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