AutismKB 2.0

Annotation Detail for IPO8


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Basic Information Top
Gene Symbol:IPO8 ( FLJ21954,FLJ26580,RANBP8 )
Gene Full Name: importin 8
Band: 12p11.21
Quick LinksEntrez ID:10526; OMIM: 605600; Uniprot ID:IPO8_HUMAN; ENSEMBL ID: ENSG00000133704; HGNC ID: 9853
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst3 / 6231948
fetus23 / 56401240
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult78 / 193912140
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor8 / 11424670
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor20 / 26384575
glioma5 / 10688346
head and neck tumor9 / 13630266
kidney tumor2 / 6895929
leukemia1 / 9584210
liver tumor7 / 9635972
lung tumor2 / 10312719
lymphoma2 / 7175527
non-neoplasia2 / 9725020
normal131 / 336030738
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites2 / 4001549
bladder1 / 2975733
blood4 / 12347832
bone5 / 7165569
bone marrow2 / 4880140
brain35 / 110098931
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus0 / 202090 
eye2 / 2110549
heart3 / 8962633
intestine13 / 23447255
kidney5 / 21177723
larynx1 / 2414541
liver11 / 20774352
lung8 / 33697423
lymph1 / 4427022
lymph node4 / 9161043
mammary gland2 / 15327113
mouth5 / 6705274
muscle6 / 10771555
nerve1 / 1576863
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta11 / 28082539
prostate7 / 18934536
salivary gland1 / 2015549
skin16 / 21057475
spleen3 / 5395255
stomach1 / 9661910
testis44 / 330442133
thymus3 / 8113136
thyroid2 / 4747342
tonsil0 / 169990 
trachea7 / 52413133
umbilical cord0 / 136800 
uterus12 / 23287851
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205701_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.3
Adipocyte4.75
AdrenalCortex5.15
Adrenalgland4.15
Amygdala4.95
Appendix5.7
AtrioventricularNode4.1
BDCA4+_DentriticCells5.8
Bonemarrow4.8
BronchialEpithelialCells4.5
CD105+_Endothelial4.8
CD14+_Monocytes5
CD19+_BCells(neg._sel.)5.05
CD33+_Myeloid6.4
CD34+6.1
CD4+_Tcells12.45
CD56+_NKCells5.6
CD71+_EarlyErythroid4.5
CD8+_Tcells6.2
CardiacMyocytes6.5
Caudatenucleus4.35
Cerebellum3.95
CerebellumPeduncles5.5
CiliaryGanglion4.45
CingulateCortex4.95
Colorectaladenocarcinoma4.85
DorsalRootGanglion3.9
FetalThyroid4.65
Fetalbrain4.75
Fetalliver4.15
Fetallung3.85
GlobusPallidus3.6
Heart6.05
Hypothalamus5.05
Kidney4.1
Leukemia_chronicMyelogenousK-5624.3
Leukemia_promyelocytic-HL-604.25
Leukemialymphoblastic(MOLT-4)4.25
Liver6.4
Lung5.2
Lymphnode4
Lymphoma_burkitts(Daudi)6.25
Lymphoma_burkitts(Raji)6.85
MedullaOblongata7.95
OccipitalLobe4.45
OlfactoryBulb3.75
Ovary3.95
Pancreas3.7
PancreaticIslet5.15
ParietalLobe5.1
Pituitary5.6
Placenta4.85
Pons5.3
PrefrontalCortex5.9
Prostate5.55
Salivarygland3.9
SkeletalMuscle6.1
Skin3.95
SmoothMuscle5.45
Spinalcord5.1
SubthalamicNucleus4.8
SuperiorCervicalGanglion6.15
TemporalLobe4.4
Testis4.15
TestisGermCell3.95
TestisIntersitial6.5
TestisLeydigCell4.85
TestisSeminiferousTubule4.2
Thalamus5
Thymus3.75
Thyroid5.65
Tongue4.9
Tonsil4.65
Trachea4.05
TrigeminalGanglion5.1
Uterus3.85
UterusCorpus4.4
WholeBlood5
Wholebrain3.95
colon4.85
pineal_day5.94
pineal_night5.88
retina5.8
small_intestine4.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12532_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.59 ± 0.33
Basal Forebrain7.56 ± 0.16
Basal Part of Pons6.98 ± 0.21
Cerebellar Cortex7.33 ± 0.28
Cerebellar Nuclei7.93 ± 0.19
Claustrum7.95 ± 0.44
Epithalamus7.34 ± 0.16
Frontal Lobe7.38 ± 0.32
Globus Pallidus8.06 ± 0.2
Hypothalamus7.42 ± 0.26
Insula7.4 ± 0.23
Limbic Lobe7.62 ± 0.29
Mesencephalon7.53 ± 0.36
Myelencephalon7.49 ± 0.35
Occipital Lobe7.6 ± 0.31
Parietal Lobe7.46 ± 0.35
Pontine Tegmentum7.56 ± 0.26
Striatum7.51 ± 0.4
Subthalamus7.41 ± 0.31
Temporal Lobe7.42 ± 0.35
Thalamus7.32 ± 0.25
White Matter7.68 ± 0.29
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ipo8CBCerebellum7.4
7.23
Ipo8CTXCerebral cortex12.83
8.72
Ipo8HIPHippocampal region14.58
13.81
Ipo8HPFHippocampal formation13.13
11.22
Ipo8HYHypothalamus4.43
3.53
Ipo8LSXLateral septal complex1.79
1.17
Ipo8MBMidbrain7.2
6.52
Ipo8MYMedulla19.08
19.79
Ipo8OLFOlfactory bulb6.8
5.41
Ipo8PPons9.6
9.52
Ipo8PALPallidum7.05
6.69
Ipo8RHPRetrohippocampal region10.55
7.49
Ipo8sAMYStriatum-like amygdalar nuclei4.28
2.85
Ipo8STRStriatum2.41
1.67
Ipo8STRdStriatum dorsal region1.86
1.38
Ipo8STRvStriatum ventral region3.71
2.22
Ipo8THThalamus4.36
3.38
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
IPO8_HUMAN_314 8 314 321 QKEYVAPR PRIDE
PAp00066853 13 553 565 ETENDDVTNVIQK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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