AutismKB 2.0

Annotation Detail for GLRX3


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Basic Information Top
Gene Symbol:GLRX3 ( FLJ11864,GLRX4,GRX3,GRX4,PICOT,TXNL2,TXNL3,bA500G10.4 )
Gene Full Name: glutaredoxin 3
Band: 10q26.3
Quick LinksEntrez ID:10539; OMIM: 612754; Uniprot ID:GLRX3_HUMAN; ENSEMBL ID: ENSG00000108010; HGNC ID: 15987
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body11 / 70761155
blastocyst7 / 62319112
fetus43 / 56401276
neonate2 / 3109764
infant0 / 236200 
juvenile4 / 5555671
adult142 / 193912173
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma7 / 17475400
breast (mammary gland) tumor11 / 94178116
cervical tumor5 / 34366145
chondrosarcoma9 / 82823108
colorectal tumor8 / 11424670
esophageal tumor2 / 17290115
gastrointestinal tumor7 / 11936958
germ cell tumor17 / 26384564
glioma7 / 10688365
head and neck tumor6 / 13630244
kidney tumor4 / 6895958
leukemia8 / 9584283
liver tumor5 / 9635951
lung tumor4 / 10312738
lymphoma4 / 7175555
non-neoplasia3 / 9725030
normal212 / 336030763
ovarian tumor3 / 7668239
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer3 / 10268029
retinoblastoma6 / 46356129
skin tumor14 / 124949112
soft tissue/muscle tissue tumor30 / 125191239
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland4 / 33197120
ascites4 / 4001599
bladder7 / 29757235
blood5 / 12347840
bone8 / 71655111
bone marrow8 / 48801163
brain69 / 110098962
cervix11 / 48171228
connective tissue22 / 149255147
ear0 / 162120 
embryonic tissue29 / 215722134
esophagus2 / 2020998
eye20 / 21105494
heart7 / 8962678
intestine18 / 23447276
kidney13 / 21177761
larynx1 / 2414541
liver13 / 20774362
lung13 / 33697438
lymph3 / 4427067
lymph node3 / 9161032
mammary gland13 / 15327184
mouth2 / 6705229
muscle9 / 10771583
nerve2 / 15768126
ovary4 / 10205139
pancreas13 / 21481260
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta15 / 28082553
prostate9 / 18934547
salivary gland1 / 2015549
skin21 / 21057499
spleen0 / 539520 
stomach3 / 9661931
testis38 / 330442114
thymus3 / 8113136
thyroid3 / 4747363
tonsil1 / 1699958
trachea3 / 5241357
umbilical cord2 / 13680146
uterus18 / 23287877
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209080_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts333.9
Adipocyte123.3
AdrenalCortex34.8
Adrenalgland47.05
Amygdala59.2
Appendix34.05
AtrioventricularNode15.95
BDCA4+_DentriticCells52.8
Bonemarrow43.8
BronchialEpithelialCells543.1
CD105+_Endothelial110.6
CD14+_Monocytes67.75
CD19+_BCells(neg._sel.)76.7
CD33+_Myeloid60.65
CD34+91.25
CD4+_Tcells41.25
CD56+_NKCells65.85
CD71+_EarlyErythroid97
CD8+_Tcells33.05
CardiacMyocytes113.85
Caudatenucleus44.55
Cerebellum44.85
CerebellumPeduncles59.7
CiliaryGanglion18.85
CingulateCortex54
Colorectaladenocarcinoma80.9
DorsalRootGanglion24
FetalThyroid54.25
Fetalbrain58.4
Fetalliver61.4
Fetallung52.55
GlobusPallidus26.3
Heart48.45
Hypothalamus62.45
Kidney43.8
Leukemia_chronicMyelogenousK-562199.4
Leukemia_promyelocytic-HL-60145.7
Leukemialymphoblastic(MOLT-4)91.85
Liver41.45
Lung18
Lymphnode45.1
Lymphoma_burkitts(Daudi)175.2
Lymphoma_burkitts(Raji)88.5
MedullaOblongata50.2
OccipitalLobe44.75
OlfactoryBulb35.15
Ovary25.5
Pancreas49.05
PancreaticIslet54.4
ParietalLobe54.2
Pituitary56.7
Placenta51
Pons53.3
PrefrontalCortex58.25
Prostate48
Salivarygland37.75
SkeletalMuscle53.7
Skin38.45
SmoothMuscle156.3
Spinalcord44.15
SubthalamicNucleus35.9
SuperiorCervicalGanglion53.8
TemporalLobe53.9
Testis89.95
TestisGermCell88.7
TestisIntersitial131.95
TestisLeydigCell80.3
TestisSeminiferousTubule73.2
Thalamus54.55
Thymus44.6
Thyroid62.25
Tongue48.25
Tonsil85.4
Trachea45.7
TrigeminalGanglion15.5
Uterus42.05
UterusCorpus45.6
WholeBlood59.3
Wholebrain63.8
colon66.45
pineal_day71.42
pineal_night68.46
retina46.15
small_intestine54.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14844_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.25 ± 0.2
Basal Forebrain9.33 ± 0.3
Basal Part of Pons9.42 ± 0.11
Cerebellar Cortex9.15 ± 0.19
Cerebellar Nuclei9.57 ± 0.23
Claustrum9.55 ± 0.3
Epithalamus8.83 ± 0.28
Frontal Lobe9.35 ± 0.23
Globus Pallidus9.47 ± 0.18
Hypothalamus9.28 ± 0.21
Insula9.22 ± 0.19
Limbic Lobe9.34 ± 0.23
Mesencephalon9.36 ± 0.3
Myelencephalon9.3 ± 0.25
Occipital Lobe9.28 ± 0.21
Parietal Lobe9.34 ± 0.24
Pontine Tegmentum9.34 ± 0.26
Striatum9.33 ± 0.2
Subthalamus9.49 ± 0.09
Temporal Lobe9.3 ± 0.23
Thalamus9.29 ± 0.15
White Matter9.38 ± 0.18
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Txnl2CBCerebellum5.36
7.79
Txnl2CTXCerebral cortex1.72
1.67
Txnl2HIPHippocampal region4.08
4.4
Txnl2HPFHippocampal formation4.03
3.68
Txnl2HYHypothalamus0.26
0.28
Txnl2LSXLateral septal complex0.19
0.28
Txnl2MBMidbrain2.61
2.88
Txnl2MYMedulla12.79
14.7
Txnl2OLFOlfactory bulb3.42
4.22
Txnl2PPons5.52
7.52
Txnl2PALPallidum0.84
0.72
Txnl2RHPRetrohippocampal region4.16
2.86
Txnl2sAMYStriatum-like amygdalar nuclei0.36
0.22
Txnl2STRStriatum0.46
0.39
Txnl2STRdStriatum dorsal region0.64
0.55
Txnl2STRvStriatum ventral region0.09
0.06
Txnl2THThalamus0.84
0.71
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
GLRX3_HUMAN_139 12 139 150 LTHAAPCMLFMK PRIDE
GLRX3_HUMAN_171 21 171 191 HNIQFSSFDIFSDEEVRQGLK PRIDE
GLRX3_HUMAN_2 11 2 12 AAGAAEAAVAA PRIDE
GLRX3_HUMAN_2 13 2 14 AAGAAEAAVAAVE PRIDE
GLRX3_HUMAN_2 14 2 15 AAGAAEAAVAAVEE PRIDE
GLRX3_HUMAN_2 19 2 20 AAGAAEAAVAAVEEVGSAG PRIDE
GLRX3_HUMAN_2 20 2 21 AAGAAEAAVAAVEEVGSAGQ PRIDE
GLRX3_HUMAN_2 21 2 22 AAGAAEAAVAAVEEVGSAGQF PRIDE
GLRX3_HUMAN_2 26 2 27 AAGAAEAAVAAVEEVGSAGQFEELLR PRIDE
GLRX3_HUMAN_245 8 245 252 ASVMLFMK PRIDE
GLRX3_HUMAN_294 14 294 307 AYSNWPTYPQLYVK PRIDE
GLRX3_HUMAN_308 11 308 318 GELVGGLDIVK PRIDE
GLRX3_HUMAN_67 25 67 91 LEAEGVPEVSEKYEISSVPTFLFFK PRIDE
GLRX3_HUMAN_79 13 79 91 YEISSVPTFLFFK PRIDE
PAp00004473 13 139 151 KLTHAAPCMLFMK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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