AutismKB 2.0

Annotation Detail for PRDX4


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Basic Information Top
Gene Symbol:PRDX4 ( AOE37-2,PRX-4 )
Gene Full Name: peroxiredoxin 4
Band: Xp22.11
Quick LinksEntrez ID:10549; OMIM: 606506; Uniprot ID:PRDX4_HUMAN; ENSEMBL ID: ENSG00000123131; HGNC ID: 17169
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst2 / 6231932
fetus169 / 564012299
neonate3 / 3109796
infant0 / 236200 
juvenile2 / 5555635
adult155 / 193912179
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor11 / 94178116
cervical tumor0 / 343660 
chondrosarcoma8 / 8282396
colorectal tumor9 / 11424678
esophageal tumor2 / 17290115
gastrointestinal tumor18 / 119369150
germ cell tumor8 / 26384530
glioma5 / 10688346
head and neck tumor6 / 13630244
kidney tumor5 / 6895972
leukemia3 / 9584231
liver tumor18 / 96359186
lung tumor15 / 103127145
lymphoma0 / 717550 
non-neoplasia6 / 9725061
normal322 / 336030795
ovarian tumor7 / 7668291
pancreatic tumor11 / 104616105
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer13 / 102680126
retinoblastoma1 / 4635621
skin tumor21 / 124949168
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites7 / 40015174
bladder2 / 2975767
blood3 / 12347824
bone11 / 71655153
bone marrow1 / 4880120
brain31 / 110098928
cervix0 / 481710 
connective tissue7 / 14925546
ear2 / 16212123
embryonic tissue12 / 21572255
esophagus2 / 2020998
eye12 / 21105456
heart12 / 89626133
intestine21 / 23447289
kidney137 / 211777646
larynx1 / 2414541
liver29 / 207743139
lung34 / 336974100
lymph0 / 442700 
lymph node3 / 9161032
mammary gland15 / 15327197
mouth2 / 6705229
muscle10 / 10771592
nerve0 / 157680 
ovary7 / 10205168
pancreas25 / 214812116
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland4 / 16585241
placenta13 / 28082546
prostate21 / 189345110
salivary gland1 / 2015549
skin30 / 210574142
spleen1 / 5395218
stomach14 / 96619144
testis22 / 33044266
thymus0 / 811310 
thyroid4 / 4747384
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord3 / 13680219
uterus15 / 23287864
vascular13 / 51780251
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201923_at
Cell line Expression level Expression bar
721_B_lymphoblasts355.45
Adipocyte565.2
AdrenalCortex17.35
Adrenalgland225.25
Amygdala42.25
Appendix34.95
AtrioventricularNode15.05
BDCA4+_DentriticCells273.25
Bonemarrow156.55
BronchialEpithelialCells985.4
CD105+_Endothelial414.25
CD14+_Monocytes111.05
CD19+_BCells(neg._sel.)113.85
CD33+_Myeloid129.5
CD34+339.95
CD4+_Tcells26.6
CD56+_NKCells126.95
CD71+_EarlyErythroid56.5
CD8+_Tcells21.4
CardiacMyocytes1030.75
Caudatenucleus37.1
Cerebellum22
CerebellumPeduncles26.1
CiliaryGanglion12.1
CingulateCortex17.1
Colorectaladenocarcinoma470
DorsalRootGanglion23.25
FetalThyroid177.65
Fetalbrain30.85
Fetalliver377.4
Fetallung221.1
GlobusPallidus10.6
Heart295.75
Hypothalamus73.95
Kidney120.45
Leukemia_chronicMyelogenousK-562292
Leukemia_promyelocytic-HL-60275.15
Leukemialymphoblastic(MOLT-4)114.1
Liver1817.05
Lung454.05
Lymphnode314.45
Lymphoma_burkitts(Daudi)352.6
Lymphoma_burkitts(Raji)436.2
MedullaOblongata21.7
OccipitalLobe7.95
OlfactoryBulb106.5
Ovary97.2
Pancreas1099.75
PancreaticIslet874.55
ParietalLobe9.9
Pituitary617.7
Placenta621.15
Pons11.85
PrefrontalCortex12.8
Prostate676.9
Salivarygland209.25
SkeletalMuscle7.65
Skin13.15
SmoothMuscle1336.2
Spinalcord113.8
SubthalamicNucleus5.8
SuperiorCervicalGanglion19.7
TemporalLobe9.75
Testis727.1
TestisGermCell363
TestisIntersitial301.1
TestisLeydigCell434.35
TestisSeminiferousTubule455.95
Thalamus29.65
Thymus147.35
Thyroid294.85
Tongue14
Tonsil104.55
Trachea404.9
TrigeminalGanglion22.65
Uterus328.8
UterusCorpus104.05
WholeBlood40.9
Wholebrain145.9
colon368.65
pineal_day201.8
pineal_night285.14
retina251.05
small_intestine444.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14531_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.79 ± 0.54
Basal Forebrain7.18 ± 0.32
Basal Part of Pons7.2 ± 0.51
Cerebellar Cortex7.33 ± 0.45
Cerebellar Nuclei7.58 ± 0.47
Claustrum6.25 ± 0.82
Epithalamus7.76 ± 0.4
Frontal Lobe7.41 ± 0.45
Globus Pallidus8.23 ± 0.27
Hypothalamus7.85 ± 0.38
Insula7.43 ± 0.41
Limbic Lobe6.84 ± 0.67
Mesencephalon7.19 ± 0.63
Myelencephalon7.21 ± 0.54
Occipital Lobe6.49 ± 0.47
Parietal Lobe6.93 ± 0.54
Pontine Tegmentum7.36 ± 0.42
Striatum7.28 ± 0.43
Subthalamus7.32 ± 0.49
Temporal Lobe7.25 ± 0.49
Thalamus7.33 ± 0.47
White Matter8.71 ± 0.69
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Prdx4CBCerebellum7.3
9.3
Prdx4CTXCerebral cortex8.6
8.06
Prdx4HIPHippocampal region2.25
2.56
Prdx4HPFHippocampal formation3.52
3.84
Prdx4HYHypothalamus3.99
3.92
Prdx4LSXLateral septal complex9.49
9.57
Prdx4MBMidbrain4.48
5.86
Prdx4MYMedulla4.2
6.23
Prdx4OLFOlfactory bulb14
12.51
Prdx4PPons3.3
4.78
Prdx4PALPallidum3.71
3.9
Prdx4RHPRetrohippocampal region6.18
6.2
Prdx4sAMYStriatum-like amygdalar nuclei2.4
2.07
Prdx4STRStriatum2.56
2.8
Prdx4STRdStriatum dorsal region2.05
2.5
Prdx4STRvStriatum ventral region1.42
1.35
Prdx4THThalamus19.64
18.56
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00001971 19 48 66 EEECHFYAGGQVYPGEASR Peptide Atlas
PRDX4_HUMAN_0 0 0 0 GLFIIDDK PRIDE
PRDX4_HUMAN_0 0 0 0 GLFIIDDKGILR PRIDE
PRDX4_HUMAN_0 0 0 0 LVQAFQYTDK PRIDE
PRDX4_HUMAN_164 22 164 185 RQGGLGPIRIPLLSDLTHQISK PRIDE
PRDX4_HUMAN_165 21 165 185 QGGLGPIRIPLLSDLTHQISK PRIDE
PRDX4_HUMAN_165 35 165 199 QGGLGPIRIPLLSDLTHQISKDYGVYLEDSGHTLR PRIDE
PRDX4_HUMAN_173 27 173 199 IPLLSDLTHQISKDYGVYLEDSGHTLR PRIDE
PRDX4_HUMAN_174 13 174 186 IPLLSDLTHQISK PRIDE
PRDX4_HUMAN_186 14 186 199 DYGVYLEDSGHTLR PRIDE
PRDX4_HUMAN_200 12 200 211 GLFIIDDKGILR PRIDE
PRDX4_HUMAN_200 8 200 207 GLFIIDDK PRIDE
PRDX4_HUMAN_212 11 212 222 QITLNDLPVGR PRIDE
PRDX4_HUMAN_213 11 213 223 QITLNDLPVGR PRIDE
PRDX4_HUMAN_230 10 230 239 LVQAFQYTDK PRIDE
PRDX4_HUMAN_230 33 230 262 LVQAFQYTDKHGEVCPAGWKPGSETIIPDPAGK PRIDE
PRDX4_HUMAN_231 10 231 240 LVQAFQYTDK PRIDE
PRDX4_HUMAN_37 9 37 45 GWETEERPR PRIDE
PRDX4_HUMAN_45 21 45 65 TREEECHFYAGGQVYPGEASR PRIDE
PRDX4_HUMAN_46 21 46 66 TREEECHFYAGGQVYPGEASR PRIDE
PRDX4_HUMAN_66 12 66 77 VSVADHSLHLSK PRIDE
PRDX4_HUMAN_80 19 80 98 ISKPAPYWEGTAVIDGEFK PRIDE
PRDX4_HUMAN_81 19 81 99 ISKPAPYWEGTAVIDGEFK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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