AutismKB 2.0

Annotation Detail for MXD4


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Basic Information Top
Gene Symbol:MXD4 ( MAD4,MST149,MSTP149,bHLHc12 )
Gene Full Name: MAX dimerization protein 4
Band: 4p16.3
Quick LinksEntrez ID:10608; OMIM: NA; Uniprot ID:MAD4_HUMAN; ENSEMBL ID: ENSG00000123933; HGNC ID: 13906
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst2 / 6231932
fetus53 / 56401293
neonate2 / 3109764
infant1 / 2362042
juvenile5 / 5555689
adult152 / 193912178
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor1 / 3436629
chondrosarcoma13 / 82823156
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor17 / 26384564
glioma16 / 106883149
head and neck tumor3 / 13630222
kidney tumor3 / 6895943
leukemia10 / 95842104
liver tumor3 / 9635931
lung tumor12 / 103127116
lymphoma3 / 7175541
non-neoplasia6 / 9725061
normal262 / 336030777
ovarian tumor6 / 7668278
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer21 / 102680204
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland0 / 331970 
ascites7 / 40015174
bladder0 / 297570 
blood4 / 12347832
bone14 / 71655195
bone marrow3 / 4880161
brain76 / 110098969
cervix1 / 4817120
connective tissue9 / 14925560
ear0 / 162120 
embryonic tissue15 / 21572269
esophagus0 / 202090 
eye26 / 211054123
heart9 / 89626100
intestine10 / 23447242
kidney22 / 211777103
larynx0 / 241450 
liver5 / 20774324
lung57 / 336974169
lymph3 / 4427067
lymph node14 / 91610152
mammary gland8 / 15327152
mouth0 / 670520 
muscle1 / 1077159
nerve6 / 15768380
ovary6 / 10205158
pancreas18 / 21481283
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta3 / 28082510
prostate30 / 189345158
salivary gland1 / 2015549
skin12 / 21057456
spleen5 / 5395292
stomach1 / 9661910
testis20 / 33044260
thymus8 / 8113198
thyroid6 / 47473126
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord1 / 1368073
uterus19 / 23287881
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210778_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.75
Adipocyte15
AdrenalCortex10.35
Adrenalgland7.9
Amygdala7.25
Appendix7.2
AtrioventricularNode5.3
BDCA4+_DentriticCells21.2
Bonemarrow7.05
BronchialEpithelialCells6.1
CD105+_Endothelial7.4
CD14+_Monocytes18.05
CD19+_BCells(neg._sel.)12.25
CD33+_Myeloid10.15
CD34+10.3
CD4+_Tcells18.6
CD56+_NKCells35.95
CD71+_EarlyErythroid11.3
CD8+_Tcells13.3
CardiacMyocytes8.6
Caudatenucleus6.55
Cerebellum12.6
CerebellumPeduncles21.9
CiliaryGanglion4.95
CingulateCortex10.3
Colorectaladenocarcinoma5.55
DorsalRootGanglion5.4
FetalThyroid7.05
Fetalbrain7.45
Fetalliver5.35
Fetallung6.2
GlobusPallidus5.3
Heart9.2
Hypothalamus8.05
Kidney5.75
Leukemia_chronicMyelogenousK-5625.9
Leukemia_promyelocytic-HL-605.95
Leukemialymphoblastic(MOLT-4)5.15
Liver9.6
Lung15.15
Lymphnode6.25
Lymphoma_burkitts(Daudi)8.45
Lymphoma_burkitts(Raji)8.15
MedullaOblongata7.3
OccipitalLobe6.7
OlfactoryBulb7.25
Ovary4.7
Pancreas5.85
PancreaticIslet7.25
ParietalLobe7.5
Pituitary13
Placenta9.2
Pons9.75
PrefrontalCortex12.4
Prostate8.7
Salivarygland5.65
SkeletalMuscle8.45
Skin5.4
SmoothMuscle9.3
Spinalcord7.85
SubthalamicNucleus6.55
SuperiorCervicalGanglion8.3
TemporalLobe6.55
Testis5.15
TestisGermCell5.75
TestisIntersitial5.95
TestisLeydigCell6.55
TestisSeminiferousTubule6.6
Thalamus7.45
Thymus30.5
Thyroid10
Tongue6.95
Tonsil7.05
Trachea5.7
TrigeminalGanglion7
Uterus8.8
UterusCorpus6.65
WholeBlood7.5
Wholebrain14.55
colon6.75
pineal_day12.36
pineal_night9.42
retina9.725
small_intestine6.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P259490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.23 ± 0.42
Basal Forebrain5.3 ± 0.6
Basal Part of Pons5.55 ± 0.34
Cerebellar Cortex5.76 ± 0.44
Cerebellar Nuclei5.09 ± 0.3
Claustrum5.08 ± 0.68
Epithalamus5.17 ± 0.46
Frontal Lobe5.42 ± 0.5
Globus Pallidus5.33 ± 0.2
Hypothalamus5.54 ± 0.56
Insula5.5 ± 0.44
Limbic Lobe5.27 ± 0.51
Mesencephalon5.26 ± 0.54
Myelencephalon5.39 ± 0.49
Occipital Lobe5.12 ± 0.46
Parietal Lobe5.32 ± 0.45
Pontine Tegmentum5.26 ± 0.39
Striatum5.04 ± 0.35
Subthalamus4.72 ± 0.28
Temporal Lobe5.48 ± 0.39
Thalamus5.44 ± 0.43
White Matter4.93 ± 0.25
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mxd4CBCerebellum46.29
57.14
Mxd4CTXCerebral cortex80.65
63.76
Mxd4HIPHippocampal region70.94
70.98
Mxd4HPFHippocampal formation75.91
68.69
Mxd4HYHypothalamus56.36
52.1
Mxd4LSXLateral septal complex56.33
52.4
Mxd4MBMidbrain53.46
51.74
Mxd4MYMedulla58.38
55.37
Mxd4OLFOlfactory bulb91.15
72.72
Mxd4PPons49.77
52.24
Mxd4PALPallidum49.77
51.83
Mxd4RHPRetrohippocampal region83.96
65.84
Mxd4sAMYStriatum-like amygdalar nuclei71.14
57.8
Mxd4STRStriatum66.6
55.94
Mxd4STRdStriatum dorsal region70.09
57.3
Mxd4STRvStriatum ventral region59.76
53.24
Mxd4THThalamus60.35
54.08
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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