AutismKB 2.0

Annotation Detail for SPAG5


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Basic Information Top
Gene Symbol:SPAG5 ( DEEPEST,MAP126,hMAP126 )
Gene Full Name: sperm associated antigen 5
Band: 17q11.2
Quick LinksEntrez ID:10615; OMIM: NA; Uniprot ID:SPAG5_HUMAN; ENSEMBL ID: ENSG00000076382; HGNC ID: 13452
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst26 / 62319417
fetus31 / 56401254
neonate7 / 31097225
infant0 / 236200 
juvenile7 / 55556125
adult116 / 193912159
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma1 / 1747557
breast (mammary gland) tumor24 / 94178254
cervical tumor5 / 34366145
chondrosarcoma5 / 8282360
colorectal tumor10 / 11424687
esophageal tumor0 / 172900 
gastrointestinal tumor10 / 11936983
germ cell tumor26 / 26384598
glioma8 / 10688374
head and neck tumor14 / 136302102
kidney tumor5 / 6895972
leukemia7 / 9584273
liver tumor6 / 9635962
lung tumor20 / 103127193
lymphoma7 / 7175597
non-neoplasia2 / 9725020
normal165 / 336030749
ovarian tumor5 / 7668265
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer6 / 10268058
retinoblastoma13 / 46356280
skin tumor30 / 124949240
soft tissue/muscle tissue tumor10 / 12519179
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites5 / 40015124
bladder0 / 297570 
blood6 / 12347848
bone8 / 71655111
bone marrow3 / 4880161
brain44 / 110098939
cervix12 / 48171249
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue45 / 215722208
esophagus0 / 202090 
eye23 / 211054108
heart1 / 8962611
intestine16 / 23447268
kidney6 / 21177728
larynx1 / 2414541
liver7 / 20774333
lung29 / 33697486
lymph5 / 44270112
lymph node1 / 9161010
mammary gland27 / 153271176
mouth10 / 67052149
muscle5 / 10771546
nerve0 / 157680 
ovary6 / 10205158
pancreas9 / 21481241
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate6 / 18934531
salivary gland2 / 2015599
skin37 / 210574175
spleen0 / 539520 
stomach2 / 9661920
testis162 / 330442490
thymus13 / 81131160
thyroid4 / 4747384
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord4 / 13680292
uterus14 / 23287860
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203145_at
Cell line Expression level Expression bar
721_B_lymphoblasts215.9
Adipocyte6.85
AdrenalCortex7.65
Adrenalgland6.05
Amygdala7.2
Appendix7.1
AtrioventricularNode5.3
BDCA4+_DentriticCells7.85
Bonemarrow9.2
BronchialEpithelialCells7.15
CD105+_Endothelial67.2
CD14+_Monocytes7.5
CD19+_BCells(neg._sel.)7.25
CD33+_Myeloid8.8
CD34+25.9
CD4+_Tcells7.4
CD56+_NKCells8
CD71+_EarlyErythroid102.1
CD8+_Tcells6.3
CardiacMyocytes11.2
Caudatenucleus6.35
Cerebellum5.8
CerebellumPeduncles8.05
CiliaryGanglion5.15
CingulateCortex7.6
Colorectaladenocarcinoma17.7
DorsalRootGanglion5.35
FetalThyroid6.95
Fetalbrain7
Fetalliver7.9
Fetallung5.85
GlobusPallidus5.3
Heart10.45
Hypothalamus7.7
Kidney6.7
Leukemia_chronicMyelogenousK-56213.65
Leukemia_promyelocytic-HL-608.85
Leukemialymphoblastic(MOLT-4)87.3
Liver10.25
Lung7.85
Lymphnode6.05
Lymphoma_burkitts(Daudi)14.45
Lymphoma_burkitts(Raji)12.7
MedullaOblongata6.45
OccipitalLobe6.4
OlfactoryBulb5.7
Ovary4.8
Pancreas5.7
PancreaticIslet7.55
ParietalLobe7.8
Pituitary8.3
Placenta7.4
Pons6.9
PrefrontalCortex8.9
Prostate8.25
Salivarygland5.75
SkeletalMuscle8.3
Skin5.35
SmoothMuscle8
Spinalcord7.6
SubthalamicNucleus6.55
SuperiorCervicalGanglion8.45
TemporalLobe6.6
Testis23.8
TestisGermCell60.2
TestisIntersitial54.6
TestisLeydigCell15.6
TestisSeminiferousTubule36.3
Thalamus7.25
Thymus7.1
Thyroid9.05
Tongue7.65
Tonsil7.05
Trachea6
TrigeminalGanglion6.9
Uterus5.8
UterusCorpus6.4
WholeBlood7.7
Wholebrain5.9
colon7.3
pineal_day8.54
pineal_night8.42
retina8.625
small_intestine7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14078_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.46 ± 0.62
Basal Forebrain4.05 ± 0.58
Basal Part of Pons4.74 ± 0.47
Cerebellar Cortex4.76 ± 0.36
Cerebellar Nuclei4.5 ± 0.42
Claustrum4.18 ± 0.82
Epithalamus3.77 ± 0.47
Frontal Lobe4.26 ± 0.67
Globus Pallidus3.56 ± 0.6
Hypothalamus4.49 ± 0.61
Insula4.46 ± 0.39
Limbic Lobe4.13 ± 0.63
Mesencephalon4.18 ± 0.73
Myelencephalon4.26 ± 0.58
Occipital Lobe4.52 ± 0.44
Parietal Lobe4.39 ± 0.58
Pontine Tegmentum4.28 ± 0.61
Striatum3.85 ± 0.63
Subthalamus4.14 ± 0.26
Temporal Lobe4.43 ± 0.44
Thalamus4.41 ± 0.52
White Matter3.39 ± 0.48
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Spag5CBCerebellum14.88
38.78
Spag5CTXCerebral cortex57.99
35.18
Spag5HIPHippocampal region8.76
9.85
Spag5HPFHippocampal formation10.28
8.95
Spag5HYHypothalamus12.89
6.02
Spag5LSXLateral septal complex6.6
5.21
Spag5MBMidbrain20.45
12.11
Spag5MYMedulla5.22
4.36
Spag5OLFOlfactory bulb17.51
9.82
Spag5PPons4.72
2.78
Spag5PALPallidum4.26
1.8
Spag5RHPRetrohippocampal region12.44
8.06
Spag5sAMYStriatum-like amygdalar nuclei11.06
5.26
Spag5STRStriatum3.05
2.15
Spag5STRdStriatum dorsal region1.72
1.5
Spag5STRvStriatum ventral region1.38
1.01
Spag5THThalamus5.36
3.76
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00010384 22 410 431 HSTSETEQLLCGRPPDLTALSR Peptide Atlas
SPAG5_HUMAN_129 20 129 148 TIVLVPSPLGQQQDMIFEAR PRIDE
SPAG5_HUMAN_230 30 230 259 EDLVPSESNAFLPSSVLWLSPSTALAADFR PRIDE
SPAG5_HUMAN_331 18 331 348 ILGSDTESWMSPLAWLEK PRIDE
SPAG5_HUMAN_349 12 349 360 GVNTSVMLENLR PRIDE
SPAG5_HUMAN_349 22 349 370 GVNTSVMLENLRQSLSLPSMLR PRIDE
SPAG5_HUMAN_361 10 361 370 QSLSLPSMLR PRIDE
SPAG5_HUMAN_371 26 371 396 DAAIGTTPFSTCSVGTWFTPSAPQEK PRIDE
SPAG5_HUMAN_397 13 397 409 STNTSQTGLVGTK PRIDE
SPAG5_HUMAN_56 20 56 75 LGLQEGSNNSSPVDFVNNKR PRIDE
SPAG5_HUMAN_89 25 89 113 WLETCQHESDEQPLDPIPQISSTPK PRIDE
SPAG5_HUMAN_920 27 920 946 TFLGSILTAVADEEPESTPVPLLGSDK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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