AutismKB 2.0

Annotation Detail for TXNIP


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Basic Information Top
Gene Symbol:TXNIP ( EST01027,HHCPA78,THIF,VDUP1 )
Gene Full Name: thioredoxin interacting protein
Band: 1q21.1
Quick LinksEntrez ID:10628; OMIM: 606599; Uniprot ID:TXNIP_HUMAN; ENSEMBL ID: ENSG00000117289; HGNC ID: 16952
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body24 / 70761339
blastocyst5 / 6231980
fetus297 / 564012526
neonate10 / 31097321
infant5 / 23620211
juvenile11 / 55556197
adult1069 / 1939121551
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma9 / 17475515
breast (mammary gland) tumor55 / 94178584
cervical tumor33 / 34366960
chondrosarcoma49 / 82823591
colorectal tumor65 / 114246568
esophageal tumor17 / 17290983
gastrointestinal tumor60 / 119369502
germ cell tumor120 / 263845454
glioma34 / 106883318
head and neck tumor71 / 136302520
kidney tumor30 / 68959435
leukemia51 / 95842532
liver tumor37 / 96359383
lung tumor11 / 103127106
lymphoma17 / 71755236
non-neoplasia150 / 972501542
normal2596 / 3360307772
ovarian tumor22 / 76682286
pancreatic tumor49 / 104616468
primitive neuroectodermal tumor of the CNS35 / 125680278
prostate cancer18 / 102680175
retinoblastoma2 / 4635643
skin tumor8 / 12494964
soft tissue/muscle tissue tumor42 / 125191335
uterine tumor60 / 90257664
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue27 / 131062060
adrenal gland39 / 331971174
ascites20 / 40015499
bladder23 / 29757772
blood244 / 1234781976
bone30 / 71655418
bone marrow38 / 48801778
brain441 / 1100989400
cervix42 / 48171871
connective tissue231 / 1492551547
ear28 / 162121727
embryonic tissue60 / 215722278
esophagus23 / 202091138
eye56 / 211054265
heart116 / 896261294
intestine293 / 2344721249
kidney152 / 211777717
larynx9 / 24145372
liver62 / 207743298
lung246 / 336974730
lymph3 / 4427067
lymph node29 / 91610316
mammary gland93 / 153271606
mouth68 / 670521014
muscle104 / 107715965
nerve27 / 157681712
ovary27 / 102051264
pancreas122 / 214812567
parathyroid26 / 205391265
pharynx27 / 41328653
pituitary gland22 / 165851326
placenta169 / 280825601
prostate111 / 189345586
salivary gland3 / 20155148
skin55 / 210574261
spleen176 / 539523262
stomach96 / 96619993
testis188 / 330442568
thymus315 / 811313882
thyroid34 / 47473716
tonsil1 / 1699958
trachea97 / 524131850
umbilical cord3 / 13680219
uterus376 / 2328781614
vascular16 / 51780308
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201009_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts205.6
Adipocyte558.85
AdrenalCortex274.3
Adrenalgland1259.05
Amygdala49.35
Appendix1598.8
AtrioventricularNode664.55
BDCA4+_DentriticCells1739.9
Bonemarrow2143.8
BronchialEpithelialCells11.15
CD105+_Endothelial269.7
CD14+_Monocytes3290.5
CD19+_BCells(neg._sel.)3748.95
CD33+_Myeloid1685.85
CD34+588.4
CD4+_Tcells4382.6
CD56+_NKCells5070.05
CD71+_EarlyErythroid679.2
CD8+_Tcells3980.5
CardiacMyocytes300
Caudatenucleus47.95
Cerebellum82.4
CerebellumPeduncles126
CiliaryGanglion457.6
CingulateCortex49.4
Colorectaladenocarcinoma180.1
DorsalRootGanglion845.15
FetalThyroid2802.65
Fetalbrain126.95
Fetalliver85.1
Fetallung1598.5
GlobusPallidus8.65
Heart602.6
Hypothalamus163.15
Kidney1059.35
Leukemia_chronicMyelogenousK-562662.35
Leukemia_promyelocytic-HL-6082.85
Leukemialymphoblastic(MOLT-4)181.25
Liver545.9
Lung3218.35
Lymphnode1393.75
Lymphoma_burkitts(Daudi)88.85
Lymphoma_burkitts(Raji)293.3
MedullaOblongata103.15
OccipitalLobe96
OlfactoryBulb1394.35
Ovary1333.85
Pancreas658.35
PancreaticIslet439.7
ParietalLobe81.75
Pituitary562.9
Placenta1128.85
Pons118.4
PrefrontalCortex879.6
Prostate877.35
Salivarygland946.15
SkeletalMuscle1234.1
Skin653.75
SmoothMuscle139.4
Spinalcord299.3
SubthalamicNucleus61.45
SuperiorCervicalGanglion394.75
TemporalLobe36.95
Testis271.6
TestisGermCell285.9
TestisIntersitial156.5
TestisLeydigCell208.45
TestisSeminiferousTubule199.9
Thalamus91.7
Thymus1881.55
Thyroid1329.65
Tongue833.7
Tonsil823.15
Trachea1231.6
TrigeminalGanglion691.9
Uterus1203.75
UterusCorpus948.15
WholeBlood3069.55
Wholebrain137.25
colon1365.25
pineal_day159.94
pineal_night160.68
retina778.1
small_intestine1661.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P97798
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.74 ± 1.19
Basal Forebrain2.57 ± 0.56
Basal Part of Pons2.44 ± 0.79
Cerebellar Cortex2.41 ± 0.71
Cerebellar Nuclei2.89 ± 0.75
Claustrum3.05 ± 0.71
Epithalamus3.26 ± 0.72
Frontal Lobe2.41 ± 1
Globus Pallidus3.9 ± 0.5
Hypothalamus2.52 ± 1.17
Insula1.87 ± 0.62
Limbic Lobe2.38 ± 0.88
Mesencephalon2.75 ± 0.82
Myelencephalon2.61 ± 0.94
Occipital Lobe2.39 ± 0.61
Parietal Lobe2.42 ± 0.72
Pontine Tegmentum2.42 ± 0.74
Striatum2.85 ± 0.88
Subthalamus2.44 ± 0.66
Temporal Lobe2.36 ± 0.87
Thalamus2.55 ± 0.77
White Matter4.68 ± 0.4
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
TxnipCBCerebellum2.07
3.63
TxnipCTXCerebral cortex1.42
1.79
TxnipHIPHippocampal region2.55
4.16
TxnipHPFHippocampal formation2.52
3.74
TxnipHYHypothalamus3.77
2.81
TxnipLSXLateral septal complex3.97
4.65
TxnipMBMidbrain2.14
3.22
TxnipMYMedulla3.51
6.06
TxnipOLFOlfactory bulb4.36
4.03
TxnipPPons5.54
8.95
TxnipPALPallidum1.7
1.93
TxnipRHPRetrohippocampal region2.12
2.52
TxnipsAMYStriatum-like amygdalar nuclei3.41
5.25
TxnipSTRStriatum2.65
3.13
TxnipSTRdStriatum dorsal region1.79
2.09
TxnipSTRvStriatum ventral region2.65
2.47
TxnipTHThalamus3.66
4.03
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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