AutismKB 2.0

Annotation Detail for EXOC5


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Basic Information Top
Gene Symbol:EXOC5 ( DKFZp666H126,HSEC10,PRO1912,SEC10,SEC10L1,SEC10P )
Gene Full Name: exocyst complex component 5
Band: 14q22.3
Quick LinksEntrez ID:10640; OMIM: 604469; Uniprot ID:EXOC5_HUMAN; ENSEMBL ID: ENSG00000070367; HGNC ID: 10696
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body11 / 70761155
blastocyst6 / 6231996
fetus44 / 56401278
neonate2 / 3109764
infant0 / 236200 
juvenile4 / 5555671
adult140 / 193912172
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma3 / 17475171
breast (mammary gland) tumor7 / 9417874
cervical tumor0 / 343660 
chondrosarcoma7 / 8282384
colorectal tumor4 / 11424635
esophageal tumor2 / 17290115
gastrointestinal tumor7 / 11936958
germ cell tumor20 / 26384575
glioma4 / 10688337
head and neck tumor11 / 13630280
kidney tumor3 / 6895943
leukemia23 / 95842239
liver tumor8 / 9635983
lung tumor7 / 10312767
lymphoma4 / 7175555
non-neoplasia10 / 97250102
normal256 / 336030776
ovarian tumor2 / 7668226
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer5 / 10268048
retinoblastoma2 / 4635643
skin tumor9 / 12494972
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland4 / 33197120
ascites4 / 4001599
bladder4 / 29757134
blood10 / 12347880
bone9 / 71655125
bone marrow13 / 48801266
brain92 / 110098983
cervix0 / 481710 
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue24 / 215722111
esophagus2 / 2020998
eye15 / 21105471
heart4 / 8962644
intestine8 / 23447234
kidney9 / 21177742
larynx2 / 2414582
liver11 / 20774352
lung17 / 33697450
lymph0 / 442700 
lymph node13 / 91610141
mammary gland9 / 15327158
mouth11 / 67052164
muscle6 / 10771555
nerve1 / 1576863
ovary4 / 10205139
pancreas6 / 21481227
parathyroid2 / 2053997
pharynx1 / 4132824
pituitary gland3 / 16585180
placenta31 / 280825110
prostate10 / 18934552
salivary gland3 / 20155148
skin11 / 21057452
spleen0 / 539520 
stomach2 / 9661920
testis103 / 330442311
thymus5 / 8113161
thyroid2 / 4747342
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus20 / 23287885
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218748_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts22.7
Adipocyte6.55
AdrenalCortex6.8
Adrenalgland5.25
Amygdala6.8
Appendix6.95
AtrioventricularNode5.6
BDCA4+_DentriticCells34.35
Bonemarrow6.2
BronchialEpithelialCells6.05
CD105+_Endothelial7
CD14+_Monocytes6.6
CD19+_BCells(neg._sel.)6.4
CD33+_Myeloid7.7
CD34+7.4
CD4+_Tcells6.55
CD56+_NKCells11.6
CD71+_EarlyErythroid5.95
CD8+_Tcells8.9
CardiacMyocytes9.75
Caudatenucleus5.55
Cerebellum5
CerebellumPeduncles7.3
CiliaryGanglion5.5
CingulateCortex6.4
Colorectaladenocarcinoma6.15
DorsalRootGanglion5.25
FetalThyroid6
Fetalbrain6.3
Fetalliver5.45
Fetallung5.05
GlobusPallidus4.8
Heart8.85
Hypothalamus6.7
Kidney5.25
Leukemia_chronicMyelogenousK-5625.55
Leukemia_promyelocytic-HL-605.5
Leukemialymphoblastic(MOLT-4)5.45
Liver8.35
Lung6.7
Lymphnode5.25
Lymphoma_burkitts(Daudi)8
Lymphoma_burkitts(Raji)9
MedullaOblongata5.6
OccipitalLobe5.55
OlfactoryBulb4.85
Ovary4.75
Pancreas5
PancreaticIslet7.1
ParietalLobe7
Pituitary7.25
Placenta6.3
Pons6
PrefrontalCortex7.75
Prostate7.1
Salivarygland4.95
SkeletalMuscle8.55
Skin5.2
SmoothMuscle7.6
Spinalcord6.4
SubthalamicNucleus5.85
SuperiorCervicalGanglion8.1
TemporalLobe5.75
Testis5.3
TestisGermCell12.7
TestisIntersitial26.35
TestisLeydigCell34.3
TestisSeminiferousTubule6.9
Thalamus6.3
Thymus4.7
Thyroid7.6
Tongue6.25
Tonsil7.4
Trachea5.2
TrigeminalGanglion6.9
Uterus4.7
UterusCorpus5.95
WholeBlood6.8
Wholebrain5.1
colon6.2
pineal_day8.58
pineal_night8.6
retina7.225
small_intestine5.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P224219
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.32 ± 0.37
Basal Forebrain7.43 ± 0.18
Basal Part of Pons7.25 ± 0.25
Cerebellar Cortex7.12 ± 0.19
Cerebellar Nuclei7.43 ± 0.21
Claustrum7.28 ± 0.43
Epithalamus8.08 ± 0.32
Frontal Lobe7.42 ± 0.35
Globus Pallidus7.88 ± 0.24
Hypothalamus7.61 ± 0.27
Insula7.32 ± 0.19
Limbic Lobe7.37 ± 0.37
Mesencephalon7.44 ± 0.26
Myelencephalon7.38 ± 0.35
Occipital Lobe7.26 ± 0.24
Parietal Lobe7.32 ± 0.29
Pontine Tegmentum7.43 ± 0.34
Striatum7.44 ± 0.24
Subthalamus7.47 ± 0.15
Temporal Lobe7.4 ± 0.28
Thalamus7.32 ± 0.26
White Matter8.19 ± 0.12
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Exoc5CBCerebellum9.4
10.94
Exoc5CTXCerebral cortex14.35
10.63
Exoc5HIPHippocampal region18.14
18.3
Exoc5HPFHippocampal formation15.43
14.17
Exoc5HYHypothalamus2.76
1.89
Exoc5LSXLateral septal complex7.44
5.73
Exoc5MBMidbrain5.24
5.71
Exoc5MYMedulla9.45
10.84
Exoc5OLFOlfactory bulb12.98
9.86
Exoc5PPons8.11
8.42
Exoc5PALPallidum1.34
1.16
Exoc5RHPRetrohippocampal region11.18
8.63
Exoc5sAMYStriatum-like amygdalar nuclei2.71
1.9
Exoc5STRStriatum2.65
1.99
Exoc5STRdStriatum dorsal region2.07
1.51
Exoc5STRvStriatum ventral region3.05
2.43
Exoc5THThalamus4.39
3.42
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
EXOC5_HUMAN_2 19 2 20 ATTAELFEEPFVADEYIER PRIDE
EXOC5_HUMAN_378 13 378 390 SIGTGGIQDLKER PRIDE
PAp00028775 17 189 205 YHDLECQLIQEFTSAQR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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