AutismKB 2.0

Annotation Detail for CES1


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Basic Information Top
Gene Symbol:CES1 ( ACAT,CEH,CES2,HMSE,HMSE1,MGC117365,PCE-1,SES1,TGH )
Gene Full Name: carboxylesterase 1
Band: 16q12.2
Quick LinksEntrez ID:1066; OMIM: 114835; Uniprot ID:EST1_HUMAN; ENSEMBL ID: ENSG00000198848; HGNC ID: 1863
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus3 / 5640125
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult170 / 193912187
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma6 / 8282372
colorectal tumor0 / 1142460 
esophageal tumor18 / 172901041
gastrointestinal tumor1 / 1193698
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor63 / 136302462
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor47 / 96359487
lung tumor28 / 103127271
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal139 / 336030741
ovarian tumor0 / 766820 
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone4 / 7165555
bone marrow0 / 488010 
brain3 / 11009892
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus18 / 20209890
eye5 / 21105423
heart3 / 8962633
intestine3 / 23447212
kidney1 / 2117774
larynx59 / 241452443
liver92 / 207743442
lung57 / 336974169
lymph0 / 442700 
lymph node0 / 916100 
mammary gland23 / 153271150
mouth3 / 6705244
muscle1 / 1077159
nerve0 / 157680 
ovary1 / 1020519
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx9 / 41328217
pituitary gland0 / 165850 
placenta4 / 28082514
prostate8 / 18934542
salivary gland0 / 201550 
skin0 / 2105740 
spleen3 / 5395255
stomach1 / 9661910
testis3 / 3304429
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea7 / 52413133
umbilical cord0 / 136800 
uterus9 / 23287838
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209616_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts13.9
Adipocyte53.75
AdrenalCortex20.1
Adrenalgland33.3
Amygdala17.45
Appendix28.1
AtrioventricularNode22
BDCA4+_DentriticCells28.35
Bonemarrow30.8
BronchialEpithelialCells13.2
CD105+_Endothelial16.9
CD14+_Monocytes72.3
CD19+_BCells(neg._sel.)17.45
CD33+_Myeloid323.65
CD34+17.1
CD4+_Tcells13.3
CD56+_NKCells14.65
CD71+_EarlyErythroid13.25
CD8+_Tcells11.25
CardiacMyocytes16.55
Caudatenucleus13.5
Cerebellum12.75
CerebellumPeduncles24.5
CiliaryGanglion17.4
CingulateCortex16.6
Colorectaladenocarcinoma14.05
DorsalRootGanglion31.6
FetalThyroid14.65
Fetalbrain17.55
Fetalliver16.1
Fetallung61.1
GlobusPallidus12.5
Heart65.4
Hypothalamus18.6
Kidney18.1
Leukemia_chronicMyelogenousK-56211.55
Leukemia_promyelocytic-HL-6015
Leukemialymphoblastic(MOLT-4)16.35
Liver3961.5
Lung347.45
Lymphnode23.25
Lymphoma_burkitts(Daudi)23.25
Lymphoma_burkitts(Raji)24.75
MedullaOblongata18.15
OccipitalLobe12.9
OlfactoryBulb18.6
Ovary15.45
Pancreas21.5
PancreaticIslet32.2
ParietalLobe18.45
Pituitary29.2
Placenta18.5
Pons18.1
PrefrontalCortex16.6
Prostate28.2
Salivarygland55.15
SkeletalMuscle39.1
Skin14.7
SmoothMuscle16.65
Spinalcord18.85
SubthalamicNucleus17.3
SuperiorCervicalGanglion26.6
TemporalLobe17.1
Testis23.95
TestisGermCell18.2
TestisIntersitial27
TestisLeydigCell28.2
TestisSeminiferousTubule28.15
Thalamus15.7
Thymus11.4
Thyroid23.3
Tongue35.75
Tonsil18.75
Trachea162.7
TrigeminalGanglion39.5
Uterus25
UterusCorpus19.05
WholeBlood38.1
Wholebrain11.35
colon15.2
pineal_day12.68
pineal_night13.5
retina27.525
small_intestine20.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9393_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.09 ± 0.96
Basal Forebrain1.6 ± 0.19
Basal Part of Pons1.29 ± 0.35
Cerebellar Cortex1.45 ± 0.7
Cerebellar Nuclei1.91 ± 0.75
Claustrum2.42 ± 0.82
Epithalamus1.58 ± 0.82
Frontal Lobe1.47 ± 0.6
Globus Pallidus2.16 ± 0.42
Hypothalamus1.63 ± 0.65
Insula1.44 ± 0.45
Limbic Lobe1.58 ± 0.58
Mesencephalon1.82 ± 0.68
Myelencephalon1.66 ± 0.61
Occipital Lobe1.8 ± 0.65
Parietal Lobe1.62 ± 0.62
Pontine Tegmentum1.66 ± 0.62
Striatum1.89 ± 0.57
Subthalamus1.79 ± 0.64
Temporal Lobe1.54 ± 0.63
Thalamus1.58 ± 0.57
White Matter2.05 ± 0.34
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ces1CBCerebellum62.78
90.08
Ces1CTXCerebral cortex100
79.9
Ces1HIPHippocampal region44.84
48.4
Ces1HPFHippocampal formation63.11
62.7
Ces1HYHypothalamus80.13
65.23
Ces1LSXLateral septal complex100
95.31
Ces1MBMidbrain67.08
61.15
Ces1MYMedulla64.19
69.71
Ces1OLFOlfactory bulb100
100
Ces1PPons57.02
57.82
Ces1PALPallidum59.1
52.32
Ces1RHPRetrohippocampal region99.95
88.68
Ces1sAMYStriatum-like amygdalar nuclei46.47
31.83
Ces1STRStriatum61.85
45.2
Ces1STRdStriatum dorsal region57.14
41.87
Ces1STRvStriatum ventral region70.88
48.8
Ces1THThalamus78.65
68.63
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
EST1_HUMAN_186 13 186 198 GNWGHLDQVAALR PRIDE
EST1_HUMAN_287 13 287 299 QKTEEELLETTLK PRIDE
EST1_HUMAN_302 11 302 312 FLSLDLQGDPR PRIDE
EST1_HUMAN_313 17 313 329 ESQPLLGTVIDGMLLLK PRIDE
EST1_HUMAN_36 28 36 63 FVSLEGFAQPVAIFLGIPFAKPPLGPLR PRIDE
EST1_HUMAN_462 20 462 481 TVIGDHGDELFSVFGAPFLK PRIDE
EST1_HUMAN_523 15 523 537 EGYLQIGANTQAAQK PRIDE
EST1_HUMAN_92 13 92 104 AGQLLSELFTNRK PRIDE
EST1_HUMAN_93 12 93 104 AGQLLSELFTNR PRIDE
PAp00002169 24 107 130 ENIPLKLSEDCLYLNIYTPADLTK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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