AutismKB 2.0

Annotation Detail for GNB5


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Basic Information Top
Gene Symbol:GNB5 ( FLJ37457,FLJ43714,GB5 )
Gene Full Name: guanine nucleotide binding protein (G protein), beta 5
Band: 15q21.2
Quick LinksEntrez ID:10681; OMIM: 604447; Uniprot ID:GBB5_HUMAN; ENSEMBL ID: ENSG00000069966; HGNC ID: 4401
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus25 / 56401244
neonate0 / 310970 
infant0 / 236200 
juvenile7 / 55556125
adult83 / 193912142
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor2 / 3436658
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor2 / 17290115
gastrointestinal tumor0 / 1193690 
germ cell tumor12 / 26384545
glioma6 / 10688356
head and neck tumor7 / 13630251
kidney tumor10 / 68959145
leukemia5 / 9584252
liver tumor4 / 9635941
lung tumor9 / 10312787
lymphoma5 / 7175569
non-neoplasia3 / 9725030
normal202 / 336030760
ovarian tumor2 / 7668226
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer2 / 10268019
retinoblastoma1 / 4635621
skin tumor1 / 1249498
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder2 / 2975767
blood5 / 12347840
bone1 / 7165513
bone marrow1 / 4880120
brain99 / 110098989
cervix6 / 48171124
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus3 / 20209148
eye22 / 211054104
heart1 / 8962611
intestine1 / 2344724
kidney26 / 211777122
larynx1 / 2414541
liver5 / 20774324
lung25 / 33697474
lymph4 / 4427090
lymph node1 / 9161010
mammary gland2 / 15327113
mouth5 / 6705274
muscle1 / 1077159
nerve1 / 1576863
ovary5 / 10205148
pancreas15 / 21481269
parathyroid3 / 20539146
pharynx0 / 413280 
pituitary gland4 / 16585241
placenta5 / 28082517
prostate3 / 18934515
salivary gland3 / 20155148
skin7 / 21057433
spleen4 / 5395274
stomach0 / 966190 
testis9 / 33044227
thymus3 / 8113136
thyroid0 / 474730 
tonsil2 / 16999117
trachea1 / 5241319
umbilical cord0 / 136800 
uterus6 / 23287825
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211871_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.05
Adipocyte2.6
AdrenalCortex2.65
Adrenalgland2.2
Amygdala2.8
Appendix2.65
AtrioventricularNode1.95
BDCA4+_DentriticCells4.05
Bonemarrow2.55
BronchialEpithelialCells2.65
CD105+_Endothelial2.7
CD14+_Monocytes2.85
CD19+_BCells(neg._sel.)8.1
CD33+_Myeloid3.4
CD34+3.45
CD4+_Tcells2.95
CD56+_NKCells3.25
CD71+_EarlyErythroid2.45
CD8+_Tcells2.8
CardiacMyocytes3.25
Caudatenucleus2.4
Cerebellum2.15
CerebellumPeduncles6.6
CiliaryGanglion1.8
CingulateCortex2.65
Colorectaladenocarcinoma2.65
DorsalRootGanglion2
FetalThyroid2.55
Fetalbrain2.65
Fetalliver2.3
Fetallung2.2
GlobusPallidus1.95
Heart3.3
Hypothalamus2.9
Kidney2.1
Leukemia_chronicMyelogenousK-5622.4
Leukemia_promyelocytic-HL-602.35
Leukemialymphoblastic(MOLT-4)2.15
Liver3.45
Lung3
Lymphnode2.3
Lymphoma_burkitts(Daudi)3.35
Lymphoma_burkitts(Raji)3.6
MedullaOblongata2.4
OccipitalLobe2.4
OlfactoryBulb2.05
Ovary1.75
Pancreas2.1
PancreaticIslet2.8
ParietalLobe2.75
Pituitary3.3
Placenta2.75
Pons2.5
PrefrontalCortex3.4
Prostate3.15
Salivarygland2.1
SkeletalMuscle2.9
Skin1.95
SmoothMuscle3.05
Spinalcord2.8
SubthalamicNucleus2.35
SuperiorCervicalGanglion2.9
TemporalLobe2.7
Testis2.3
TestisGermCell2.25
TestisIntersitial2.25
TestisLeydigCell2.6
TestisSeminiferousTubule2.3
Thalamus2.7
Thymus2.15
Thyroid3.35
Tongue2.55
Tonsil2.6
Trachea2.2
TrigeminalGanglion2.55
Uterus2.2
UterusCorpus2.35
WholeBlood2.9
Wholebrain6.7
colon2.7
pineal_day10.52
pineal_night10.38
retina3.25
small_intestine2.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7284_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.96 ± 0.34
Basal Forebrain7.14 ± 0.19
Basal Part of Pons7.75 ± 0.22
Cerebellar Cortex7.49 ± 0.16
Cerebellar Nuclei7.53 ± 0.43
Claustrum6.73 ± 0.53
Epithalamus6.7 ± 0.36
Frontal Lobe7.21 ± 0.46
Globus Pallidus5.73 ± 0.41
Hypothalamus7.41 ± 0.26
Insula7.22 ± 0.24
Limbic Lobe6.94 ± 0.58
Mesencephalon6.9 ± 0.56
Myelencephalon7.06 ± 0.63
Occipital Lobe6.88 ± 0.63
Parietal Lobe7.25 ± 0.47
Pontine Tegmentum7.08 ± 0.53
Striatum7.03 ± 0.55
Subthalamus7.05 ± 0.43
Temporal Lobe7.37 ± 0.38
Thalamus7.19 ± 0.38
White Matter4.69 ± 0.29
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Gnb5CBCerebellum39.52
32.71
Gnb5CTXCerebral cortex53.47
43.03
Gnb5HIPHippocampal region47.74
40.8
Gnb5HPFHippocampal formation42.92
35.93
Gnb5HYHypothalamus10.72
7.13
Gnb5LSXLateral septal complex9.53
6.21
Gnb5MBMidbrain11.62
9.16
Gnb5MYMedulla22.98
19.32
Gnb5OLFOlfactory bulb68.82
43.16
Gnb5PPons18.55
14.69
Gnb5PALPallidum24.48
19.91
Gnb5RHPRetrohippocampal region36.4
28.37
Gnb5sAMYStriatum-like amygdalar nuclei27.66
18.19
Gnb5STRStriatum100
100
Gnb5STRdStriatum dorsal region100
100
Gnb5STRvStriatum ventral region100
98.28
Gnb5THThalamus26.02
19.85
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00077418 19 270 288 SGQCVQAFETHESDINSVR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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