AutismKB 2.0

Annotation Detail for TBR1


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Basic Information Top
Gene Symbol:TBR1 ( MGC141978,TES-56 )
Gene Full Name: T-box, brain, 1
Band: 2q24.2
Quick LinksEntrez ID:10716; OMIM: 604616; Uniprot ID:TBR1_HUMAN; ENSEMBL ID: ENSG00000136535; HGNC ID: 11590
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus116 / 564012205
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult11 / 19391215
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma3 / 10688328
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal165 / 336030749
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain163 / 1100989148
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 220025_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.65
Adipocyte3.6
AdrenalCortex3.9
Adrenalgland3.2
Amygdala6.8
Appendix4
AtrioventricularNode2.9
BDCA4+_DentriticCells4
Bonemarrow3.6
BronchialEpithelialCells3.55
CD105+_Endothelial3.7
CD14+_Monocytes3.85
CD19+_BCells(neg._sel.)4
CD33+_Myeloid4.7
CD34+4.6
CD4+_Tcells4.05
CD56+_NKCells4.45
CD71+_EarlyErythroid3.45
CD8+_Tcells3.55
CardiacMyocytes5
Caudatenucleus3.3
Cerebellum3
CerebellumPeduncles4.2
CiliaryGanglion2.55
CingulateCortex9.65
Colorectaladenocarcinoma3.65
DorsalRootGanglion2.8
FetalThyroid3.55
Fetalbrain4.9
Fetalliver3.25
Fetallung2.95
GlobusPallidus10
Heart4.9
Hypothalamus4
Kidney3.1
Leukemia_chronicMyelogenousK-5623.3
Leukemia_promyelocytic-HL-603.2
Leukemialymphoblastic(MOLT-4)2.95
Liver4.8
Lung4.05
Lymphnode3.15
Lymphoma_burkitts(Daudi)4.65
Lymphoma_burkitts(Raji)5.15
MedullaOblongata5.45
OccipitalLobe3.7
OlfactoryBulb2.85
Ovary2.4
Pancreas2.9
PancreaticIslet3.85
ParietalLobe5.1
Pituitary4.3
Placenta3.75
Pons4.15
PrefrontalCortex8.15
Prostate4.25
Salivarygland3
SkeletalMuscle4.7
Skin2.9
SmoothMuscle4.1
Spinalcord3.95
SubthalamicNucleus3.4
SuperiorCervicalGanglion4.9
TemporalLobe4.35
Testis3.15
TestisGermCell3.1
TestisIntersitial3.1
TestisLeydigCell3.65
TestisSeminiferousTubule3.1
Thalamus3.7
Thymus2.85
Thyroid4.55
Tongue3.75
Tonsil3.6
Trachea3.1
TrigeminalGanglion3.9
Uterus3
UterusCorpus3.4
WholeBlood4
Wholebrain10.45
colon3.7
pineal_day4.58
pineal_night4.46
retina4.475
small_intestine3.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_4783_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.21 ± 0.97
Basal Forebrain3.84 ± 0.25
Basal Part of Pons4.32 ± 0.47
Cerebellar Cortex4.18 ± 0.52
Cerebellar Nuclei4.14 ± 0.51
Claustrum7.24 ± 0.51
Epithalamus4.03 ± 0.86
Frontal Lobe4.94 ± 1.04
Globus Pallidus3.41 ± 1.44
Hypothalamus4.06 ± 0.58
Insula5.15 ± 0.67
Limbic Lobe5.82 ± 0.89
Mesencephalon4.81 ± 0.98
Myelencephalon4.84 ± 0.82
Occipital Lobe6.43 ± 0.99
Parietal Lobe5.6 ± 0.91
Pontine Tegmentum5.06 ± 1.04
Striatum2.8 ± 1.79
Subthalamus4.73 ± 0.56
Temporal Lobe5.36 ± 0.63
Thalamus4.01 ± 0.84
White Matter3.04 ± 2
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tbr1CBCerebellum0.82
1.13
Tbr1CTXCerebral cortex20.98
15.77
Tbr1HIPHippocampal region8.12
5
Tbr1HPFHippocampal formation9.37
6.58
Tbr1HYHypothalamus0.69
0.7
Tbr1LSXLateral septal complex1.31
0.96
Tbr1MBMidbrain1.77
1.39
Tbr1MYMedulla0.92
0.87
Tbr1OLFOlfactory bulb9.88
6.77
Tbr1PPons1.08
1
Tbr1PALPallidum0.8
0.6
Tbr1RHPRetrohippocampal region11.98
8.88
Tbr1sAMYStriatum-like amygdalar nuclei0.28
0.19
Tbr1STRStriatum2.52
2.08
Tbr1STRdStriatum dorsal region3.36
2.9
Tbr1STRvStriatum ventral region1.03
0.66
Tbr1THThalamus1.56
1.22
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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