AutismKB 2.0

Annotation Detail for PLK4


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Basic Information Top
Gene Symbol:PLK4 ( SAK,STK18 )
Gene Full Name: polo-like kinase 4
Band: 4q28.1
Quick LinksEntrez ID:10733; OMIM: 605031; Uniprot ID:PLK4_HUMAN; ENSEMBL ID: ENSG00000142731; HGNC ID: 11397
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst8 / 62319128
fetus17 / 56401230
neonate2 / 3109764
infant0 / 236200 
juvenile1 / 5555617
adult26 / 193912113
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor1 / 1729057
gastrointestinal tumor2 / 11936916
germ cell tumor5 / 26384518
glioma1 / 1068839
head and neck tumor1 / 1363027
kidney tumor1 / 6895914
leukemia6 / 9584262
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal67 / 336030719
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma1 / 4635621
skin tumor1 / 1249498
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder1 / 2975733
blood1 / 1234788
bone2 / 7165527
bone marrow4 / 4880181
brain9 / 11009898
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue13 / 21572260
esophagus1 / 2020949
eye2 / 2110549
heart0 / 896260 
intestine3 / 23447212
kidney6 / 21177728
larynx0 / 241450 
liver0 / 2077430 
lung1 / 3369742
lymph1 / 4427022
lymph node4 / 9161043
mammary gland3 / 15327119
mouth1 / 6705214
muscle3 / 10771527
nerve0 / 157680 
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta5 / 28082517
prostate2 / 18934510
salivary gland0 / 201550 
skin3 / 21057414
spleen0 / 539520 
stomach1 / 9661910
testis39 / 330442118
thymus4 / 8113149
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211088_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.45
Adipocyte6.15
AdrenalCortex7.65
Adrenalgland6.15
Amygdala6.25
Appendix13.25
AtrioventricularNode6.85
BDCA4+_DentriticCells6.25
Bonemarrow6.85
BronchialEpithelialCells5.95
CD105+_Endothelial6.8
CD14+_Monocytes6.75
CD19+_BCells(neg._sel.)6.45
CD33+_Myeloid8.55
CD34+7.45
CD4+_Tcells6.3
CD56+_NKCells6.95
CD71+_EarlyErythroid11.95
CD8+_Tcells5.55
CardiacMyocytes9.9
Caudatenucleus5.8
Cerebellum5.05
CerebellumPeduncles9.35
CiliaryGanglion9.35
CingulateCortex7.4
Colorectaladenocarcinoma6.25
DorsalRootGanglion6.4
FetalThyroid6.75
Fetalbrain6.05
Fetalliver6.6
Fetallung4.75
GlobusPallidus6.2
Heart11.7
Hypothalamus6.55
Kidney6.55
Leukemia_chronicMyelogenousK-5625.7
Leukemia_promyelocytic-HL-605.5
Leukemialymphoblastic(MOLT-4)4.75
Liver11.4
Lung6.7
Lymphnode5.1
Lymphoma_burkitts(Daudi)8.3
Lymphoma_burkitts(Raji)9.4
MedullaOblongata5.6
OccipitalLobe5.55
OlfactoryBulb4.9
Ovary4.45
Pancreas5.45
PancreaticIslet6.8
ParietalLobe8
Pituitary7.35
Placenta6.2
Pons7
PrefrontalCortex7.65
Prostate7.2
Salivarygland5.85
SkeletalMuscle16.8
Skin8.15
SmoothMuscle7.05
Spinalcord6.65
SubthalamicNucleus7.6
SuperiorCervicalGanglion32.15
TemporalLobe6.9
Testis5.3
TestisGermCell5
TestisIntersitial11.9
TestisLeydigCell8
TestisSeminiferousTubule6.7
Thalamus6.55
Thymus4.7
Thyroid7.45
Tongue6.95
Tonsil6.35
Trachea5.2
TrigeminalGanglion9.85
Uterus4.95
UterusCorpus22.4
WholeBlood6.75
Wholebrain5.1
colon6.3
pineal_day7.58
pineal_night7.46
retina7.5
small_intestine6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P912925
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.57 ± 1.24
Basal Forebrain1.9 ± 0.25
Basal Part of Pons1.71 ± 0.42
Cerebellar Cortex1.66 ± 0.68
Cerebellar Nuclei2.22 ± 0.82
Claustrum2.73 ± 0.73
Epithalamus1.72 ± 0.82
Frontal Lobe1.88 ± 0.72
Globus Pallidus2.44 ± 0.42
Hypothalamus2.26 ± 0.82
Insula2.31 ± 1.19
Limbic Lobe2 ± 0.73
Mesencephalon2.09 ± 0.66
Myelencephalon1.98 ± 0.7
Occipital Lobe2.05 ± 0.72
Parietal Lobe1.98 ± 0.81
Pontine Tegmentum2.18 ± 0.96
Striatum2.14 ± 0.67
Subthalamus2.79 ± 2.01
Temporal Lobe1.96 ± 0.74
Thalamus1.86 ± 0.69
White Matter2.51 ± 0.54
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Plk4CBCerebellum2.26
2.38
Plk4CTXCerebral cortex5.87
2.1
Plk4HIPHippocampal region1.56
1.17
Plk4HPFHippocampal formation2.5
1.34
Plk4HYHypothalamus1.06
0.64
Plk4LSXLateral septal complex0.92
0.78
Plk4MBMidbrain2.21
1.36
Plk4MYMedulla4.6
2.73
Plk4OLFOlfactory bulb8.09
3.35
Plk4PPons3.97
2.63
Plk4PALPallidum1.28
0.74
Plk4RHPRetrohippocampal region4.19
1.57
Plk4sAMYStriatum-like amygdalar nuclei2.51
1.33
Plk4STRStriatum1.75
1.01
Plk4STRdStriatum dorsal region1.51
0.96
Plk4STRvStriatum ventral region2.36
1.11
Plk4THThalamus1.93
1.02
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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