AutismKB 2.0

Annotation Detail for SIX2


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Basic Information Top
Gene Symbol:SIX2 ( - )
Gene Full Name: SIX homeobox 2
Band: 2p21
Quick LinksEntrez ID:10736; OMIM: 604994; Uniprot ID:SIX2_HUMAN; ENSEMBL ID: ENSG00000170577; HGNC ID: 10888
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus0 / 5640120 
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult14 / 19391217
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor2 / 3436658
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma1 / 1068839
head and neck tumor0 / 1363020 
kidney tumor3 / 6895943
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal1 / 33603070 
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain2 / 11009891
cervix12 / 48171249
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine0 / 2344720 
kidney3 / 21177714
larynx0 / 241450 
liver0 / 2077430 
lung9 / 33697426
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206511_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.6
Adipocyte7.15
AdrenalCortex8.7
Adrenalgland6.45
Amygdala7.4
Appendix9.2
AtrioventricularNode7.55
BDCA4+_DentriticCells6.4
Bonemarrow8.1
BronchialEpithelialCells6.8
CD105+_Endothelial7.05
CD14+_Monocytes7.55
CD19+_BCells(neg._sel.)7.4
CD33+_Myeloid8.15
CD34+6.7
CD4+_Tcells6.4
CD56+_NKCells5.6
CD71+_EarlyErythroid5.7
CD8+_Tcells6.5
CardiacMyocytes12.1
Caudatenucleus6.55
Cerebellum6.1
CerebellumPeduncles9.2
CiliaryGanglion5.45
CingulateCortex9.25
Colorectaladenocarcinoma8.1
DorsalRootGanglion6.2
FetalThyroid7.15
Fetalbrain7.2
Fetalliver6.95
Fetallung5.95
GlobusPallidus5.9
Heart11.65
Hypothalamus7.8
Kidney6.75
Leukemia_chronicMyelogenousK-5627.1
Leukemia_promyelocytic-HL-606.45
Leukemialymphoblastic(MOLT-4)6.4
Liver10.6
Lung7.9
Lymphnode6.45
Lymphoma_burkitts(Daudi)9.75
Lymphoma_burkitts(Raji)10.7
MedullaOblongata6.6
OccipitalLobe7.55
OlfactoryBulb5.7
Ovary6.3
Pancreas6.05
PancreaticIslet7.95
ParietalLobe8.45
Pituitary16.3
Placenta7.4
Pons7.75
PrefrontalCortex8.65
Prostate9.45
Salivarygland5.85
SkeletalMuscle11.45
Skin6.6
SmoothMuscle8.15
Spinalcord7.75
SubthalamicNucleus7
SuperiorCervicalGanglion10.75
TemporalLobe6.95
Testis6.35
TestisGermCell6
TestisIntersitial6.2
TestisLeydigCell7.75
TestisSeminiferousTubule6.2
Thalamus7.55
Thymus6.3
Thyroid8.9
Tongue8.4
Tonsil7.35
Trachea6.65
TrigeminalGanglion9.15
Uterus6
UterusCorpus7.45
WholeBlood7.8
Wholebrain6.15
colon7.25
pineal_day7.7
pineal_night8.84
retina9.075
small_intestine6.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9582_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.21 ± 0.96
Basal Forebrain1.7 ± 0.2
Basal Part of Pons1.57 ± 0.38
Cerebellar Cortex1.59 ± 0.68
Cerebellar Nuclei2.08 ± 0.89
Claustrum2.71 ± 0.92
Epithalamus1.58 ± 0.75
Frontal Lobe1.62 ± 0.59
Globus Pallidus2.38 ± 0.32
Hypothalamus1.8 ± 0.72
Insula1.79 ± 0.36
Limbic Lobe1.91 ± 0.8
Mesencephalon1.91 ± 0.78
Myelencephalon1.84 ± 0.64
Occipital Lobe1.88 ± 0.64
Parietal Lobe1.91 ± 0.78
Pontine Tegmentum1.92 ± 0.72
Striatum2.02 ± 0.6
Subthalamus1.9 ± 0.62
Temporal Lobe1.69 ± 0.64
Thalamus1.81 ± 0.66
White Matter2.38 ± 0.39
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Six2HYHypothalamus100
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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