Annotation Detail for MAP3K2
Basic Information Top
| Gene Symbol: | MAP3K2 ( MEKK2,MEKK2B ) |
|---|---|
| Gene Full Name: | mitogen-activated protein kinase kinase kinase 2 |
| Band: | 2q14.3 |
| Quick Links | Entrez ID:10746; OMIM: 609487; Uniprot ID:M3K2_HUMAN; ENSEMBL ID: ENSG00000169967; HGNC ID: 6854 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.145605
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 2 / 70761 | 28 |  |
| blastocyst | 1 / 62319 | 16 | |
| fetus | 31 / 564012 | 54 |  |
| neonate | 0 / 31097 | 0 | |
| infant | 2 / 23620 | 84 | |
| juvenile | 2 / 55556 | 35 | |
| adult | 49 / 1939121 | 25 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 1 / 17475 | 57 | |
| breast (mammary gland) tumor | 1 / 94178 | 10 |  |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 7 / 82823 | 84 | |
| colorectal tumor | 4 / 114246 | 35 | |
| esophageal tumor | 1 / 17290 | 57 | |
| gastrointestinal tumor | 4 / 119369 | 33 | |
| germ cell tumor | 13 / 263845 | 49 | |
| glioma | 3 / 106883 | 28 | |
| head and neck tumor | 1 / 136302 | 7 | |
| kidney tumor | 0 / 68959 | 0 | |
| leukemia | 4 / 95842 | 41 | |
| liver tumor | 2 / 96359 | 20 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 1 / 97250 | 10 | |
| normal | 92 / 3360307 | 27 | |
| ovarian tumor | 2 / 76682 | 26 | |
| pancreatic tumor | 3 / 104616 | 28 | |
| primitive neuroectodermal tumor of the CNS | 1 / 125680 | 7 | |
| prostate cancer | 4 / 102680 | 38 | |
| retinoblastoma | 1 / 46356 | 21 | |
| skin tumor | 3 / 124949 | 24 | |
| soft tissue/muscle tissue tumor | 4 / 125191 | 31 | |
| uterine tumor | 0 / 90257 | 0 |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 1 / 13106 | 76 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 3 / 123478 | 24 | |
| bone | 1 / 71655 | 13 | |
| bone marrow | 1 / 48801 | 20 | |
| brain | 11 / 1100989 | 9 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 8 / 149255 | 53 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 5 / 215722 | 23 | |
| esophagus | 1 / 20209 | 49 | |
| eye | 7 / 211054 | 33 | |
| heart | 2 / 89626 | 22 | |
| intestine | 5 / 234472 | 21 | |
| kidney | 5 / 211777 | 23 | |
| larynx | 0 / 24145 | 0 | |
| liver | 13 / 207743 | 62 | |
| lung | 9 / 336974 | 26 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 6 / 91610 | 65 | |
| mammary gland | 1 / 153271 | 6 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 5 / 107715 | 46 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 3 / 102051 | 29 | |
| pancreas | 14 / 214812 | 65 | |
| parathyroid | 2 / 20539 | 97 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 5 / 280825 | 17 | |
| prostate | 5 / 189345 | 26 | |
| salivary gland | 1 / 20155 | 49 | |
| skin | 6 / 210574 | 28 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 3 / 96619 | 31 | |
| testis | 12 / 330442 | 36 | |
| thymus | 2 / 81131 | 24 | |
| thyroid | 1 / 47473 | 21 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 1 / 52413 | 19 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 2 / 232878 | 8 | |
| vascular | 0 / 51780 | 0 |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 221695_s_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 6.15 | |
| Adipocyte | 5.25 | |
| AdrenalCortex | 6 | |
| Adrenalgland | 4.75 | |
| Amygdala | 5.4 | |
| Appendix | 6.2 | |
| AtrioventricularNode | 4.7 | |
| BDCA4+_DentriticCells | 8.25 | |
| Bonemarrow | 5.35 | |
| BronchialEpithelialCells | 5.1 | |
| CD105+_Endothelial | 5.25 | |
| CD14+_Monocytes | 5.65 | |
| CD19+_BCells(neg._sel.) | 5.65 | |
| CD33+_Myeloid | 7.3 | |
| CD34+ | 6.75 | |
| CD4+_Tcells | 5.75 | |
| CD56+_NKCells | 7.55 | |
| CD71+_EarlyErythroid | 5 | |
| CD8+_Tcells | 5 | |
| CardiacMyocytes | 7.65 | |
| Caudatenucleus | 4.8 | |
| Cerebellum | 4.6 | |
| CerebellumPeduncles | 6.4 | |
| CiliaryGanglion | 4.15 | |
| CingulateCortex | 6 | |
| Colorectaladenocarcinoma | 5.25 | |
| DorsalRootGanglion | 4.25 | |
| FetalThyroid | 5.2 | |
| Fetalbrain | 5.4 | |
| Fetalliver | 6.25 | |
| Fetallung | 4.2 | |
| GlobusPallidus | 4.3 | |
| Heart | 7.5 | |
| Hypothalamus | 5.6 | |
| Kidney | 4.65 | |
| Leukemia_chronicMyelogenousK-562 | 4.75 | |
| Leukemia_promyelocytic-HL-60 | 4.8 | |
| Leukemialymphoblastic(MOLT-4) | 4.1 | |
| Liver | 7.55 | |
| Lung | 5.85 | |
| Lymphnode | 4.7 | |
| Lymphoma_burkitts(Daudi) | 7.1 | |
| Lymphoma_burkitts(Raji) | 7.95 | |
| MedullaOblongata | 6 | |
| OccipitalLobe | 4.75 | |
| OlfactoryBulb | 4.15 | |
| Ovary | 3.85 | |
| Pancreas | 4.55 | |
| PancreaticIslet | 7.4 | |
| ParietalLobe | 6 | |
| Pituitary | 6.95 | |
| Placenta | 5.35 | |
| Pons | 5.3 | |
| PrefrontalCortex | 6.6 | |
| Prostate | 6.05 | |
| Salivarygland | 4.8 | |
| SkeletalMuscle | 7.6 | |
| Skin | 4.5 | |
| SmoothMuscle | 6.75 | |
| Spinalcord | 5.65 | |
| SubthalamicNucleus | 5.1 | |
| SuperiorCervicalGanglion | 14.25 | |
| TemporalLobe | 5.05 | |
| Testis | 4.6 | |
| TestisGermCell | 4.55 | |
| TestisIntersitial | 4.6 | |
| TestisLeydigCell | 5.45 | |
| TestisSeminiferousTubule | 4.55 | |
| Thalamus | 5.6 | |
| Thymus | 4.1 | |
| Thyroid | 6.5 | |
| Tongue | 5.55 | |
| Tonsil | 5.6 | |
| Trachea | 4.45 | |
| TrigeminalGanglion | 5.7 | |
| Uterus | 4.3 | |
| UterusCorpus | 5.15 | |
| WholeBlood | 15.2 | |
| Wholebrain | 4.3 | |
| colon | 6.05 | |
| pineal_day | 6.64 | |
| pineal_night | 6.5 | |
| retina | 6.7 | |
| small_intestine | 5.05 | |
- Probe name: A_23_P313645
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 6.6 ± 0.32 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 6.74 ± 0.17 | |
| Basal Part of Pons | 6.36 ± 0.23 | |
| Cerebellar Cortex | 6.66 ± 0.18 | |
| Cerebellar Nuclei | 6.44 ± 0.21 | |
| Claustrum | 6.78 ± 0.25 | |
| Epithalamus | 6.76 ± 0.26 | |
| Frontal Lobe | 6.48 ± 0.22 | |
| Globus Pallidus | 6.9 ± 0.28 | |
| Hypothalamus | 6.56 ± 0.2 | |
| Insula | 6.46 ± 0.28 | |
| Limbic Lobe | 6.63 ± 0.33 | |
| Mesencephalon | 6.61 ± 0.29 | |
| Myelencephalon | 6.6 ± 0.27 | |
| Occipital Lobe | 6.89 ± 0.3 | |
| Parietal Lobe | 6.57 ± 0.27 | |
| Pontine Tegmentum | 6.6 ± 0.28 | |
| Striatum | 6.72 ± 0.23 | |
| Subthalamus | 6.49 ± 0.05 | |
| Temporal Lobe | 6.56 ± 0.27 | |
| Thalamus | 6.57 ± 0.23 | |
| White Matter | 7.27 ± 0.15 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Map3k2 | CB | Cerebellum | 14.57 | |
| 13.8 | | |||
| Map3k2 | CTX | Cerebral cortex | 31.29 | |
| 21.8 | | |||
| Map3k2 | HIP | Hippocampal region | 31.39 | |
| 43.64 | | |||
| Map3k2 | HPF | Hippocampal formation | 29.06 | |
| 32.35 | | |||
| Map3k2 | HY | Hypothalamus | 7.49 | |
| 5.56 | | |||
| Map3k2 | LSX | Lateral septal complex | 5.94 | |
| 3.99 | | |||
| Map3k2 | MB | Midbrain | 14.5 | |
| 12.23 | | |||
| Map3k2 | MY | Medulla | 10.45 | |
| 9.42 | | |||
| Map3k2 | OLF | Olfactory bulb | 25.85 | |
| 18.42 | | |||
| Map3k2 | P | Pons | 10.95 | |
| 10.61 | | |||
| Map3k2 | PAL | Pallidum | 8.22 | |
| 6.28 | | |||
| Map3k2 | RHP | Retrohippocampal region | 26.4 | |
| 19.9 | | |||
| Map3k2 | sAMY | Striatum-like amygdalar nuclei | 8.81 | |
| 5.52 | | |||
| Map3k2 | STR | Striatum | 13.43 | |
| 9.04 | | |||
| Map3k2 | STRd | Striatum dorsal region | 12.4 | |
| 8.42 | | |||
| Map3k2 | STRv | Striatum ventral region | 23.3 | |
| 14.95 | | |||
| Map3k2 | TH | Thalamus | 10.65 | |
| 8.36 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| M3K2_HUMAN_23 | 9 | 23 | 31 | PALSLQETR | PRIDE |
| M3K2_HUMAN_62 | 8 | 62 | 69 | PVKLEDLR | PRIDE |