AutismKB 2.0

Annotation Detail for TRAF3IP2


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Basic Information Top
Gene Symbol:TRAF3IP2 ( ACT1,C6orf2,C6orf4,C6orf5,C6orf6,CIKS,DKFZp586G0522,MGC3581 )
Gene Full Name: TRAF3 interacting protein 2
Band: 6q21
Quick LinksEntrez ID:10758; OMIM: 607043; Uniprot ID:CIKS_HUMAN; ENSEMBL ID: ENSG00000056972; HGNC ID: 1343
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus39 / 56401269
neonate3 / 3109796
infant1 / 2362042
juvenile1 / 5555617
adult124 / 193912163
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor6 / 9417863
cervical tumor6 / 34366174
chondrosarcoma3 / 8282336
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor28 / 263845106
glioma6 / 10688356
head and neck tumor8 / 13630258
kidney tumor4 / 6895958
leukemia3 / 9584231
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma8 / 71755111
non-neoplasia15 / 97250154
normal189 / 336030756
ovarian tumor4 / 7668252
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor19 / 124949152
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor12 / 90257132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland4 / 33197120
ascites3 / 4001574
bladder1 / 2975733
blood8 / 12347864
bone3 / 7165541
bone marrow1 / 4880120
brain44 / 110098939
cervix6 / 48171124
connective tissue14 / 14925593
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye8 / 21105437
heart9 / 89626100
intestine7 / 23447229
kidney18 / 21177784
larynx5 / 24145207
liver2 / 2077439
lung34 / 336974100
lymph6 / 44270135
lymph node1 / 9161010
mammary gland8 / 15327152
mouth3 / 6705244
muscle3 / 10771527
nerve0 / 157680 
ovary4 / 10205139
pancreas15 / 21481269
parathyroid3 / 20539146
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta19 / 28082567
prostate7 / 18934536
salivary gland0 / 201550 
skin27 / 210574128
spleen4 / 5395274
stomach10 / 96619103
testis11 / 33044233
thymus13 / 81131160
thyroid0 / 474730 
tonsil1 / 1699958
trachea5 / 5241395
umbilical cord0 / 136800 
uterus27 / 232878115
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 215411_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts29.6
Adipocyte16.6
AdrenalCortex8.8
Adrenalgland7.4
Amygdala9.6
Appendix8.95
AtrioventricularNode6.45
BDCA4+_DentriticCells9.35
Bonemarrow8.45
BronchialEpithelialCells82.3
CD105+_Endothelial8.8
CD14+_Monocytes9.3
CD19+_BCells(neg._sel.)29.3
CD33+_Myeloid10.55
CD34+16.7
CD4+_Tcells13.95
CD56+_NKCells10.3
CD71+_EarlyErythroid6.15
CD8+_Tcells8.7
CardiacMyocytes10.75
Caudatenucleus7.55
Cerebellum6.9
CerebellumPeduncles9.5
CiliaryGanglion5.95
CingulateCortex7.45
Colorectaladenocarcinoma8.5
DorsalRootGanglion6.45
FetalThyroid10.25
Fetalbrain8.25
Fetalliver7.6
Fetallung10.05
GlobusPallidus5.75
Heart10.8
Hypothalamus9.9
Kidney7
Leukemia_chronicMyelogenousK-5629.9
Leukemia_promyelocytic-HL-606.9
Leukemialymphoblastic(MOLT-4)8.55
Liver16.75
Lung12.15
Lymphnode7.4
Lymphoma_burkitts(Daudi)10.9
Lymphoma_burkitts(Raji)11.2
MedullaOblongata7.5
OccipitalLobe7.4
OlfactoryBulb6.7
Ovary5.9
Pancreas7.05
PancreaticIslet18.1
ParietalLobe8.7
Pituitary13.6
Placenta24.2
Pons8.15
PrefrontalCortex10.5
Prostate22.4
Salivarygland7.3
SkeletalMuscle9.35
Skin6.95
SmoothMuscle23.55
Spinalcord9.1
SubthalamicNucleus7.1
SuperiorCervicalGanglion9.5
TemporalLobe7.6
Testis7.15
TestisGermCell7.05
TestisIntersitial7.25
TestisLeydigCell8.5
TestisSeminiferousTubule7.25
Thalamus8.25
Thymus8.45
Thyroid15.65
Tongue8.5
Tonsil8.85
Trachea8.8
TrigeminalGanglion8.6
Uterus12.25
UterusCorpus7.75
WholeBlood9.25
Wholebrain7.2
colon11.25
pineal_day10.48
pineal_night10.04
retina11.25
small_intestine8.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_6774_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.7 ± 0.91
Basal Forebrain2.82 ± 0.4
Basal Part of Pons1.89 ± 0.45
Cerebellar Cortex1.97 ± 0.61
Cerebellar Nuclei2.45 ± 0.88
Claustrum2.66 ± 0.64
Epithalamus2.86 ± 0.78
Frontal Lobe2.2 ± 0.78
Globus Pallidus4.03 ± 0.46
Hypothalamus2.38 ± 0.96
Insula1.82 ± 0.66
Limbic Lobe2.37 ± 0.76
Mesencephalon2.55 ± 0.73
Myelencephalon2.49 ± 0.68
Occipital Lobe2.52 ± 0.77
Parietal Lobe2.35 ± 0.64
Pontine Tegmentum2.57 ± 0.86
Striatum3.12 ± 0.58
Subthalamus2.15 ± 0.88
Temporal Lobe2.28 ± 0.73
Thalamus2.47 ± 0.62
White Matter2.26 ± 0.3
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Traf3ip2CBCerebellum0.68
1.13
Traf3ip2CTXCerebral cortex0.46
0.34
Traf3ip2HIPHippocampal region0.31
0.58
Traf3ip2HPFHippocampal formation0.48
0.63
Traf3ip2HYHypothalamus0.04
0
Traf3ip2LSXLateral septal complex0
0
Traf3ip2MBMidbrain0.34
0.34
Traf3ip2MYMedulla0.43
0.49
Traf3ip2OLFOlfactory bulb0.65
0.76
Traf3ip2PPons0.2
0.24
Traf3ip2PALPallidum0.6
0.47
Traf3ip2RHPRetrohippocampal region0.79
0.73
Traf3ip2sAMYStriatum-like amygdalar nuclei0.97
0.69
Traf3ip2STRStriatum0.54
0.33
Traf3ip2STRdStriatum dorsal region0.54
0.32
Traf3ip2STRvStriatum ventral region0.27
0.15
Traf3ip2THThalamus0.2
0.21
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00080092 15 412 426 VFITYSMDTAMEVVK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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