AutismKB 2.0

Annotation Detail for TOB2


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Basic Information Top
Gene Symbol:TOB2 ( TOB4,TOBL,TROB2 )
Gene Full Name: transducer of ERBB2, 2
Band: 22q13.2
Quick LinksEntrez ID:10766; OMIM: 607396; Uniprot ID:TOB2_HUMAN; ENSEMBL ID: ENSG00000183864; HGNC ID: 11980
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body10 / 70761141
blastocyst1 / 6231916
fetus26 / 56401246
neonate1 / 3109732
infant0 / 236200 
juvenile3 / 5555653
adult112 / 193912157
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor3 / 3436687
chondrosarcoma9 / 82823108
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor9 / 26384534
glioma11 / 106883102
head and neck tumor4 / 13630229
kidney tumor1 / 6895914
leukemia5 / 9584252
liver tumor4 / 9635941
lung tumor2 / 10312719
lymphoma10 / 71755139
non-neoplasia3 / 9725030
normal147 / 336030743
ovarian tumor1 / 7668213
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer9 / 10268087
retinoblastoma7 / 46356151
skin tumor13 / 124949104
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland1 / 3319730
ascites1 / 4001524
bladder2 / 2975767
blood3 / 12347824
bone7 / 7165597
bone marrow0 / 488010 
brain43 / 110098939
cervix9 / 48171186
connective tissue8 / 14925553
ear1 / 1621261
embryonic tissue15 / 21572269
esophagus0 / 202090 
eye22 / 211054104
heart4 / 8962644
intestine9 / 23447238
kidney9 / 21177742
larynx0 / 241450 
liver5 / 20774324
lung14 / 33697441
lymph1 / 4427022
lymph node10 / 91610109
mammary gland4 / 15327126
mouth1 / 6705214
muscle5 / 10771546
nerve2 / 15768126
ovary4 / 10205139
pancreas3 / 21481213
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta10 / 28082535
prostate17 / 18934589
salivary gland0 / 201550 
skin15 / 21057471
spleen1 / 5395218
stomach4 / 9661941
testis5 / 33044215
thymus3 / 8113136
thyroid3 / 4747363
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus10 / 23287842
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221496_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.35
Adipocyte4.9
AdrenalCortex35.25
Adrenalgland6.6
Amygdala4.95
Appendix4.8
AtrioventricularNode3.85
BDCA4+_DentriticCells5.45
Bonemarrow4.95
BronchialEpithelialCells4.7
CD105+_Endothelial5
CD14+_Monocytes5.2
CD19+_BCells(neg._sel.)7.2
CD33+_Myeloid6.45
CD34+7.2
CD4+_Tcells5.45
CD56+_NKCells6
CD71+_EarlyErythroid4.7
CD8+_Tcells4.65
CardiacMyocytes6.1
Caudatenucleus4.4
Cerebellum24.55
CerebellumPeduncles10.6
CiliaryGanglion3.4
CingulateCortex5.05
Colorectaladenocarcinoma4.9
DorsalRootGanglion4.05
FetalThyroid5.55
Fetalbrain4.9
Fetalliver4.4
Fetallung3.95
GlobusPallidus3.7
Heart25
Hypothalamus5.8
Kidney4.65
Leukemia_chronicMyelogenousK-5624.35
Leukemia_promyelocytic-HL-604.25
Leukemialymphoblastic(MOLT-4)3.9
Liver32.25
Lung40.7
Lymphnode4.3
Lymphoma_burkitts(Daudi)6.3
Lymphoma_burkitts(Raji)7.05
MedullaOblongata4.45
OccipitalLobe4.25
OlfactoryBulb8.45
Ovary3.3
Pancreas4.05
PancreaticIslet5.2
ParietalLobe5.35
Pituitary5.85
Placenta5.1
Pons4.7
PrefrontalCortex24.4
Prostate41.05
Salivarygland4
SkeletalMuscle12.25
Skin3.9
SmoothMuscle5.5
Spinalcord5.3
SubthalamicNucleus4.5
SuperiorCervicalGanglion5.7
TemporalLobe4.6
Testis4.7
TestisGermCell4.15
TestisIntersitial4.1
TestisLeydigCell4.8
TestisSeminiferousTubule4.3
Thalamus5
Thymus19.4
Thyroid11.45
Tongue8.2
Tonsil4.85
Trachea4.2
TrigeminalGanglion5.05
Uterus6.1
UterusCorpus4.5
WholeBlood5.4
Wholebrain4.7
colon5
pineal_day51.94
pineal_night17.3
retina15.225
small_intestine4.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P335813
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.48 ± 0.35
Basal Forebrain5.68 ± 0.39
Basal Part of Pons5.82 ± 0.4
Cerebellar Cortex6.21 ± 0.34
Cerebellar Nuclei5.27 ± 0.37
Claustrum5.04 ± 0.8
Epithalamus6.57 ± 0.62
Frontal Lobe5.61 ± 0.61
Globus Pallidus6.06 ± 0.55
Hypothalamus5.54 ± 0.57
Insula5.5 ± 0.42
Limbic Lobe5.57 ± 0.57
Mesencephalon5.67 ± 0.63
Myelencephalon5.71 ± 0.54
Occipital Lobe5.6 ± 0.46
Parietal Lobe5.57 ± 0.62
Pontine Tegmentum5.45 ± 0.61
Striatum5.67 ± 0.6
Subthalamus5.02 ± 0.34
Temporal Lobe5.6 ± 0.43
Thalamus5.82 ± 0.54
White Matter7.18 ± 0.49
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tob2CBCerebellum13.84
14.17
Tob2CTXCerebral cortex5.99
4.21
Tob2HIPHippocampal region5.69
6.2
Tob2HPFHippocampal formation4.37
4.45
Tob2HYHypothalamus2.95
2.5
Tob2LSXLateral septal complex1.72
1.5
Tob2MBMidbrain3.55
3.04
Tob2MYMedulla5.76
5.74
Tob2OLFOlfactory bulb15.19
12.85
Tob2PPons6.07
6.29
Tob2PALPallidum2.68
2.04
Tob2RHPRetrohippocampal region1.77
1.35
Tob2sAMYStriatum-like amygdalar nuclei0.68
0.43
Tob2STRStriatum3.79
3.47
Tob2STRdStriatum dorsal region3.38
3.83
Tob2STRvStriatum ventral region7.98
5.01
Tob2THThalamus5.48
4.34
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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