AutismKB 2.0

Annotation Detail for ARPP21


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Basic Information Top
Gene Symbol:ARPP21 ( ARPP-21,FLJ32997,R3HDM3,RCS,TARPP )
Gene Full Name: cAMP-regulated phosphoprotein, 21kDa
Band: 3p22.3
Quick LinksEntrez ID:10777; OMIM: 605488; Uniprot ID:ARP21_HUMAN; ENSEMBL ID: ENSG00000172995; HGNC ID: 16968
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus55 / 56401297
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult43 / 193912122
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus19 / 56401233
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult2 / 19391211
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor20 / 26384575
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia8 / 9725082
normal266 / 336030779
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor18 / 125191143
uterine tumor0 / 902570 
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor3 / 26384511
glioma2 / 10688318
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal34 / 336030710
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain258 / 1100989234
cervix0 / 481710 
connective tissue18 / 149255120
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye2 / 2110549
heart6 / 8962666
intestine0 / 2344720 
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung3 / 3369748
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth1 / 6705214
muscle5 / 10771546
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis5 / 33044215
thymus63 / 81131776
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular1 / 5178019
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain32 / 110098929
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung1 / 3369742
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus20 / 81131246
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 220359_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.2
Adipocyte5.2
AdrenalCortex5.8
Adrenalgland4.55
Amygdala142
Appendix8.8
AtrioventricularNode4.7
BDCA4+_DentriticCells5.4
Bonemarrow5.7
BronchialEpithelialCells5.15
CD105+_Endothelial5.25
CD14+_Monocytes5.5
CD19+_BCells(neg._sel.)5.55
CD33+_Myeloid6.65
CD34+6.6
CD4+_Tcells5.5
CD56+_NKCells5.9
CD71+_EarlyErythroid5
CD8+_Tcells4.8
CardiacMyocytes7.1
Caudatenucleus3111.75
Cerebellum4.3
CerebellumPeduncles6.1
CiliaryGanglion4.05
CingulateCortex28.9
Colorectaladenocarcinoma5.25
DorsalRootGanglion4.25
FetalThyroid5.1
Fetalbrain22.75
Fetalliver4.65
Fetallung4.15
GlobusPallidus13.7
Heart7.05
Hypothalamus12.2
Kidney4.45
Leukemia_chronicMyelogenousK-5624.75
Leukemia_promyelocytic-HL-604.65
Leukemialymphoblastic(MOLT-4)4.2
Liver7.1
Lung5.75
Lymphnode4.5
Lymphoma_burkitts(Daudi)6.85
Lymphoma_burkitts(Raji)7.55
MedullaOblongata594.35
OccipitalLobe68.65
OlfactoryBulb4.15
Ovary3.55
Pancreas4.25
PancreaticIslet5.65
ParietalLobe14.25
Pituitary6.15
Placenta5.25
Pons436.5
PrefrontalCortex43.3
Prostate6.1
Salivarygland4.25
SkeletalMuscle7.15
Skin4.85
SmoothMuscle5.85
Spinalcord5.65
SubthalamicNucleus12.7
SuperiorCervicalGanglion7.7
TemporalLobe13.9
Testis4.5
TestisGermCell4.3
TestisIntersitial4.45
TestisLeydigCell5.3
TestisSeminiferousTubule4.5
Thalamus21
Thymus4.1
Thyroid6.4
Tongue5.55
Tonsil5.1
Trachea4.45
TrigeminalGanglion6.1
Uterus4.25
UterusCorpus4.95
WholeBlood5.65
Wholebrain146.4
colon5.25
pineal_day6.44
pineal_night6.32
retina6.3
small_intestine5.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P315602
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.87 ± 0.76
Basal Forebrain7.87 ± 0.5
Basal Part of Pons9.27 ± 0.38
Cerebellar Cortex8.79 ± 0.19
Cerebellar Nuclei7.81 ± 0.79
Claustrum8.07 ± 0.75
Epithalamus6.82 ± 0.82
Frontal Lobe8.38 ± 0.53
Globus Pallidus5.76 ± 0.6
Hypothalamus7.67 ± 0.77
Insula8.42 ± 0.35
Limbic Lobe8.06 ± 0.83
Mesencephalon7.54 ± 0.82
Myelencephalon7.94 ± 0.97
Occipital Lobe8.08 ± 0.64
Parietal Lobe8.09 ± 0.81
Pontine Tegmentum7.93 ± 0.58
Striatum7 ± 0.94
Subthalamus8.84 ± 0.12
Temporal Lobe8.33 ± 0.55
Thalamus7.98 ± 0.6
White Matter5.35 ± 0.54
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018