AutismKB 2.0

Annotation Detail for WDR4


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Basic Information Top
Gene Symbol:WDR4 ( TRM82 )
Gene Full Name: WD repeat domain 4
Band: 21q22.3
Quick LinksEntrez ID:10785; OMIM: 605924; Uniprot ID:WDR4_HUMAN; ENSEMBL ID: ENSG00000160193; HGNC ID: 12756
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus19 / 56401233
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult39 / 193912120
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma4 / 8282348
colorectal tumor5 / 11424643
esophageal tumor1 / 1729057
gastrointestinal tumor5 / 11936941
germ cell tumor26 / 26384598
glioma3 / 10688328
head and neck tumor2 / 13630214
kidney tumor2 / 6895929
leukemia3 / 9584231
liver tumor3 / 9635931
lung tumor7 / 10312767
lymphoma3 / 7175541
non-neoplasia0 / 972500 
normal82 / 336030724
ovarian tumor2 / 7668226
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer1 / 1026809
retinoblastoma1 / 4635621
skin tumor3 / 12494924
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone2 / 7165527
bone marrow2 / 4880140
brain33 / 110098929
cervix2 / 4817141
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus1 / 2020949
eye6 / 21105428
heart1 / 8962611
intestine12 / 23447251
kidney8 / 21177737
larynx1 / 2414541
liver4 / 20774319
lung16 / 33697447
lymph3 / 4427067
lymph node5 / 9161054
mammary gland2 / 15327113
mouth2 / 6705229
muscle1 / 1077159
nerve0 / 157680 
ovary3 / 10205129
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta5 / 28082517
prostate2 / 18934510
salivary gland0 / 201550 
skin5 / 21057423
spleen4 / 5395274
stomach4 / 9661941
testis4 / 33044212
thymus3 / 8113136
thyroid0 / 474730 
tonsil1 / 1699958
trachea2 / 5241338
umbilical cord0 / 136800 
uterus10 / 23287842
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221632_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.9
Adipocyte3.8
AdrenalCortex4.05
Adrenalgland3.3
Amygdala4.05
Appendix3.95
AtrioventricularNode2.9
BDCA4+_DentriticCells4.25
Bonemarrow3.9
BronchialEpithelialCells3.85
CD105+_Endothelial3.9
CD14+_Monocytes4.15
CD19+_BCells(neg._sel.)4.2
CD33+_Myeloid4.95
CD34+4.85
CD4+_Tcells4.3
CD56+_NKCells4.65
CD71+_EarlyErythroid3.6
CD8+_Tcells3.85
CardiacMyocytes4.85
Caudatenucleus3.45
Cerebellum3.1
CerebellumPeduncles4.35
CiliaryGanglion2.7
CingulateCortex3.95
Colorectaladenocarcinoma3.9
DorsalRootGanglion2.9
FetalThyroid3.8
Fetalbrain3.9
Fetalliver3.3
Fetallung3.3
GlobusPallidus2.8
Heart5
Hypothalamus4.25
Kidney3.1
Leukemia_chronicMyelogenousK-5623.5
Leukemia_promyelocytic-HL-603.4
Leukemialymphoblastic(MOLT-4)3.15
Liver5.15
Lung4.35
Lymphnode3.4
Lymphoma_burkitts(Daudi)5
Lymphoma_burkitts(Raji)5.55
MedullaOblongata3.55
OccipitalLobe3.45
OlfactoryBulb3.05
Ovary2.55
Pancreas3.1
PancreaticIslet4.15
ParietalLobe4.05
Pituitary4.55
Placenta4.1
Pons3.7
PrefrontalCortex4.85
Prostate4.6
Salivarygland3.1
SkeletalMuscle4.45
Skin3.15
SmoothMuscle4.45
Spinalcord4.35
SubthalamicNucleus3.5
SuperiorCervicalGanglion4.5
TemporalLobe3.55
Testis3.6
TestisGermCell3.25
TestisIntersitial3.25
TestisLeydigCell3.85
TestisSeminiferousTubule3.3
Thalamus3.9
Thymus3.1
Thyroid4.95
Tongue3.75
Tonsil3.75
Trachea3.2
TrigeminalGanglion3.9
Uterus3.2
UterusCorpus3.65
WholeBlood4.3
Wholebrain3.35
colon3.95
pineal_day4.78
pineal_night4.66
retina4.675
small_intestine3.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1506_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.17 ± 0.88
Basal Forebrain2.8 ± 0.42
Basal Part of Pons2.71 ± 0.28
Cerebellar Cortex3.23 ± 0.53
Cerebellar Nuclei3.21 ± 0.73
Claustrum3.63 ± 0.9
Epithalamus2.64 ± 0.76
Frontal Lobe2.86 ± 0.74
Globus Pallidus2.66 ± 0.65
Hypothalamus2.65 ± 0.78
Insula3.17 ± 0.58
Limbic Lobe3.02 ± 0.7
Mesencephalon3.19 ± 0.66
Myelencephalon3.03 ± 0.69
Occipital Lobe3.61 ± 0.6
Parietal Lobe3.12 ± 0.65
Pontine Tegmentum2.98 ± 0.72
Striatum2.91 ± 0.68
Subthalamus3.24 ± 0.34
Temporal Lobe2.88 ± 0.72
Thalamus2.93 ± 0.62
White Matter2.32 ± 0.09
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00068059 20 52 71 GEDAPLDQGSGAILASTFSK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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