AutismKB 2.0

Annotation Detail for NCKAP1


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Basic Information Top
Gene Symbol:NCKAP1 ( FLJ11291,HEM2,KIAA0587,MGC8981,NAP1,NAP125 )
Gene Full Name: NCK-associated protein 1
Band: 2q32.1
Quick LinksEntrez ID:10787; OMIM: 604891; Uniprot ID:NCKP1_HUMAN; ENSEMBL ID: ENSG00000061676; HGNC ID: 7666
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body18 / 70761254
blastocyst12 / 62319192
fetus71 / 564012125
neonate4 / 31097128
infant1 / 2362042
juvenile2 / 5555635
adult243 / 1939121125
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma6 / 17475343
breast (mammary gland) tumor10 / 94178106
cervical tumor4 / 34366116
chondrosarcoma12 / 82823144
colorectal tumor18 / 114246157
esophageal tumor2 / 17290115
gastrointestinal tumor19 / 119369159
germ cell tumor51 / 263845193
glioma14 / 106883130
head and neck tumor23 / 136302168
kidney tumor9 / 68959130
leukemia5 / 9584252
liver tumor9 / 9635993
lung tumor5 / 10312748
lymphoma0 / 717550 
non-neoplasia16 / 97250164
normal392 / 3360307116
ovarian tumor8 / 76682104
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer3 / 10268029
retinoblastoma2 / 4635643
skin tumor19 / 124949152
soft tissue/muscle tissue tumor19 / 125191151
uterine tumor17 / 90257188
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites8 / 40015199
bladder8 / 29757268
blood2 / 12347816
bone8 / 71655111
bone marrow4 / 4880181
brain206 / 1100989187
cervix4 / 4817183
connective tissue25 / 149255167
ear4 / 16212246
embryonic tissue39 / 215722180
esophagus2 / 2020998
eye14 / 21105466
heart8 / 8962689
intestine33 / 234472140
kidney28 / 211777132
larynx2 / 2414582
liver12 / 20774357
lung38 / 336974112
lymph0 / 442700 
lymph node0 / 916100 
mammary gland23 / 153271150
mouth19 / 67052283
muscle5 / 10771546
nerve0 / 157680 
ovary6 / 10205158
pancreas19 / 21481288
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland5 / 16585301
placenta28 / 28082599
prostate9 / 18934547
salivary gland1 / 2015549
skin31 / 210574147
spleen0 / 539520 
stomach12 / 96619124
testis63 / 330442190
thymus4 / 8113149
thyroid4 / 4747384
tonsil0 / 169990 
trachea17 / 52413324
umbilical cord0 / 136800 
uterus47 / 232878201
vascular11 / 51780212
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207738_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts17.3
Adipocyte354.7
AdrenalCortex246.55
Adrenalgland188.95
Amygdala1772.4
Appendix349.4
AtrioventricularNode140.6
BDCA4+_DentriticCells8.35
Bonemarrow91.05
BronchialEpithelialCells632.9
CD105+_Endothelial36.55
CD14+_Monocytes8.85
CD19+_BCells(neg._sel.)11.05
CD33+_Myeloid13.6
CD34+16.45
CD4+_Tcells8.25
CD56+_NKCells40.6
CD71+_EarlyErythroid7.9
CD8+_Tcells10.15
CardiacMyocytes622.25
Caudatenucleus342
Cerebellum168.5
CerebellumPeduncles342.7
CiliaryGanglion213.55
CingulateCortex512.9
Colorectaladenocarcinoma560.5
DorsalRootGanglion228.15
FetalThyroid503.65
Fetalbrain1022
Fetalliver190.75
Fetallung259.7
GlobusPallidus334.55
Heart48.45
Hypothalamus386.9
Kidney169.9
Leukemia_chronicMyelogenousK-562186.35
Leukemia_promyelocytic-HL-60147.5
Leukemialymphoblastic(MOLT-4)49.45
Liver110.85
Lung106.4
Lymphnode142.85
Lymphoma_burkitts(Daudi)89.2
Lymphoma_burkitts(Raji)121.75
MedullaOblongata364.15
OccipitalLobe656.9
OlfactoryBulb287.6
Ovary232.15
Pancreas280.8
PancreaticIslet415.15
ParietalLobe319.1
Pituitary546.6
Placenta329.05
Pons345.3
PrefrontalCortex909.85
Prostate488.25
Salivarygland267.05
SkeletalMuscle187.8
Skin246.9
SmoothMuscle563.6
Spinalcord361.15
SubthalamicNucleus565
SuperiorCervicalGanglion221.4
TemporalLobe428.85
Testis124.5
TestisGermCell348.9
TestisIntersitial237.95
TestisLeydigCell245.4
TestisSeminiferousTubule192.7
Thalamus307.8
Thymus86.35
Thyroid1153.55
Tongue345.85
Tonsil189.15
Trachea284.4
TrigeminalGanglion173.45
Uterus863.15
UterusCorpus201.4
WholeBlood67.55
Wholebrain490.85
colon724.45
pineal_day399.28
pineal_night413.48
retina313.3
small_intestine511.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P73239
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.95 ± 0.64
Basal Forebrain8.91 ± 0.19
Basal Part of Pons9.26 ± 0.25
Cerebellar Cortex8.97 ± 0.15
Cerebellar Nuclei9.04 ± 0.41
Claustrum8.98 ± 0.47
Epithalamus8.79 ± 0.22
Frontal Lobe9.39 ± 0.37
Globus Pallidus8.27 ± 0.26
Hypothalamus9.1 ± 0.21
Insula9.44 ± 0.27
Limbic Lobe9.36 ± 0.59
Mesencephalon9.06 ± 0.5
Myelencephalon9.07 ± 0.45
Occipital Lobe8.8 ± 0.58
Parietal Lobe9.24 ± 0.36
Pontine Tegmentum9.14 ± 0.37
Striatum8.89 ± 0.56
Subthalamus9.54 ± 0.21
Temporal Lobe9.33 ± 0.3
Thalamus8.99 ± 0.33
White Matter7.64 ± 0.31
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nckap1CBCerebellum97.72
100
Nckap1CTXCerebral cortex100
100
Nckap1HIPHippocampal region100
100
Nckap1HPFHippocampal formation100
100
Nckap1HYHypothalamus100
100
Nckap1LSXLateral septal complex100
100
Nckap1MBMidbrain100
100
Nckap1MYMedulla100
100
Nckap1OLFOlfactory bulb100
100
Nckap1PPons100
100
Nckap1PALPallidum100
100
Nckap1RHPRetrohippocampal region100
100
Nckap1sAMYStriatum-like amygdalar nuclei100
100
Nckap1STRStriatum100
100
Nckap1STRdStriatum dorsal region100
100
Nckap1STRvStriatum ventral region100
100
Nckap1THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
NCKP1_HUMAN_202 15 202 216 SLSDALISLQMVYPR PRIDE
NCKP1_HUMAN_329 12 329 340 EAAVSHAGSMHR PRIDE
NCKP1_HUMAN_658 9 658 666 EKPGVESMR PRIDE
NCKP1_HUMAN_882 14 882 895 TSFDKPDQMAALFK PRIDE
PAp00041777 13 558 570 MFQQCLELPSQSR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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