AutismKB 2.0

Annotation Detail for IQGAP2


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Basic Information Top
Gene Symbol:IQGAP2 ( - )
Gene Full Name: IQ motif containing GTPase activating protein 2
Band: 5q13.3
Quick LinksEntrez ID:10788; OMIM: 605401; Uniprot ID:IQGA2_HUMAN; ENSEMBL ID: ENSG00000145703; HGNC ID: 6111
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst5 / 6231980
fetus25 / 56401244
neonate1 / 3109732
infant0 / 236200 
juvenile7 / 55556125
adult70 / 193912136
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor4 / 11424635
esophageal tumor1 / 1729057
gastrointestinal tumor4 / 11936933
germ cell tumor7 / 26384526
glioma1 / 1068839
head and neck tumor6 / 13630244
kidney tumor1 / 6895914
leukemia4 / 9584241
liver tumor8 / 9635983
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal132 / 336030739
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer5 / 10268048
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites2 / 4001549
bladder0 / 297570 
blood3 / 12347824
bone0 / 716550 
bone marrow2 / 4880140
brain13 / 110098911
cervix0 / 481710 
connective tissue5 / 14925533
ear3 / 16212185
embryonic tissue9 / 21572241
esophagus1 / 2020949
eye5 / 21105423
heart0 / 896260 
intestine10 / 23447242
kidney14 / 21177766
larynx2 / 2414582
liver16 / 20774377
lung4 / 33697411
lymph0 / 442700 
lymph node1 / 9161010
mammary gland0 / 1532710 
mouth1 / 6705214
muscle4 / 10771537
nerve0 / 157680 
ovary1 / 1020519
pancreas5 / 21481223
parathyroid3 / 20539146
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta21 / 28082574
prostate6 / 18934531
salivary gland3 / 20155148
skin1 / 2105744
spleen2 / 5395237
stomach4 / 9661941
testis101 / 330442305
thymus0 / 811310 
thyroid4 / 4747384
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord0 / 136800 
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203474_at
Cell line Expression level Expression bar
721_B_lymphoblasts53.9
Adipocyte6.7
AdrenalCortex22.45
Adrenalgland7.85
Amygdala6.15
Appendix18.35
AtrioventricularNode11.6
BDCA4+_DentriticCells195.45
Bonemarrow9.4
BronchialEpithelialCells6
CD105+_Endothelial37.4
CD14+_Monocytes155.25
CD19+_BCells(neg._sel.)14.15
CD33+_Myeloid220.6
CD34+228.4
CD4+_Tcells84.05
CD56+_NKCells256.25
CD71+_EarlyErythroid55.85
CD8+_Tcells83.2
CardiacMyocytes11.05
Caudatenucleus5.8
Cerebellum6.2
CerebellumPeduncles9.95
CiliaryGanglion9.1
CingulateCortex8.45
Colorectaladenocarcinoma47.1
DorsalRootGanglion9.3
FetalThyroid12.8
Fetalbrain9.5
Fetalliver73.15
Fetallung17.4
GlobusPallidus7.95
Heart10
Hypothalamus6.75
Kidney7.85
Leukemia_chronicMyelogenousK-56216.55
Leukemia_promyelocytic-HL-605.9
Leukemialymphoblastic(MOLT-4)10.95
Liver14.1
Lung8.1
Lymphnode20.45
Lymphoma_burkitts(Daudi)9.7
Lymphoma_burkitts(Raji)11.1
MedullaOblongata7.5
OccipitalLobe6.45
OlfactoryBulb12.7
Ovary7.25
Pancreas12.7
PancreaticIslet17.05
ParietalLobe9.2
Pituitary10.15
Placenta33.95
Pons8.45
PrefrontalCortex7.2
Prostate20
Salivarygland37.2
SkeletalMuscle11.6
Skin9.3
SmoothMuscle9.05
Spinalcord7.4
SubthalamicNucleus8.25
SuperiorCervicalGanglion25.85
TemporalLobe7.2
Testis5.9
TestisGermCell6.6
TestisIntersitial8.9
TestisLeydigCell9
TestisSeminiferousTubule7.35
Thalamus7.45
Thymus5.25
Thyroid43.55
Tongue8.9
Tonsil8.65
Trachea7.6
TrigeminalGanglion9.05
Uterus5.7
UterusCorpus7.45
WholeBlood121.55
Wholebrain5
colon43.2
pineal_day10.18
pineal_night9.56
retina10.325
small_intestine44.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1557_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.11 ± 0.87
Basal Forebrain2.62 ± 0.33
Basal Part of Pons2.25 ± 0.53
Cerebellar Cortex2.43 ± 0.74
Cerebellar Nuclei2.91 ± 0.71
Claustrum3.03 ± 0.87
Epithalamus5.39 ± 0.99
Frontal Lobe2.65 ± 0.99
Globus Pallidus3.72 ± 0.72
Hypothalamus2.75 ± 0.99
Insula3.04 ± 0.75
Limbic Lobe2.82 ± 0.74
Mesencephalon2.87 ± 0.74
Myelencephalon2.82 ± 0.88
Occipital Lobe2.34 ± 0.84
Parietal Lobe2.54 ± 0.88
Pontine Tegmentum2.78 ± 1.01
Striatum3.41 ± 1.03
Subthalamus2.64 ± 0.8
Temporal Lobe2.84 ± 0.79
Thalamus2.48 ± 0.7
White Matter2.45 ± 0.82
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
IQGA2_HUMAN_0 0 0 0 LIFQMPQNK PRIDE
IQGA2_HUMAN_0 0 0 0 TLVGSENPPLTVIR PRIDE
IQGA2_HUMAN_1057 17 1057 1073 VLNSIISSLDLLPYGLR PRIDE
IQGA2_HUMAN_1098 9 1098 1106 IVGNLLYYR PRIDE
IQGA2_HUMAN_1466 10 1466 1475 GKGEPKGAKR PRIDE
IQGA2_HUMAN_1489 15 1489 1503 GVLLDIDDLQTNQFK PRIDE
IQGA2_HUMAN_158 13 158 170 LGIAPQIQDLLGK PRIDE
IQGA2_HUMAN_198 29 198 226 IGGILANELSVDEAALHAAVIAINEAVEK PRIDE
IQGA2_HUMAN_227 11 227 237 GIAEQTVVTLR PRIDE
IQGA2_HUMAN_395 11 395 405 SPAIGLNNLDK PRIDE
IQGA2_HUMAN_471 31 471 501 TLETLLLPTANISDVDPAHAQHYQDVLYHAK PRIDE
IQGA2_HUMAN_514 22 514 535 VLWLDEIQQAVDEANVDEDRAK PRIDE
IQGA2_HUMAN_553 9 553 561 SSDILSVLK PRIDE
IQGA2_HUMAN_562 23 562 584 SSTSNANDIIPECADKYYDALVK PRIDE
IQGA2_HUMAN_607 11 607 617 KYDYYYNTDSK PRIDE
IQGA2_HUMAN_653 13 653 665 ENIWSASEELLLR PRIDE
IQGA2_HUMAN_666 11 666 676 FQATSSGPILR PRIDE
IQGA2_HUMAN_743 13 743 755 LQYFRDHNNEIVK PRIDE
IQGA2_HUMAN_771 14 771 784 TLVGSENPPLTVIR PRIDE
IQGA2_HUMAN_816 15 816 830 ANQQLEKDLNLMDIK PRIDE
IQGA2_HUMAN_901 9 901 909 LIFQMPQNK PRIDE
IQGA2_HUMAN_950 16 950 965 VDQVQDIVTGNPTVIK PRIDE
IQGA2_HUMAN_966 7 966 972 MVVSFNR PRIDE
IQGA2_HUMAN_996 13 996 1008 SLIINTNPVEVYK PRIDE
PAp00007464 23 563 585 SSTSNANDIIPECADKYYDALVK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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