AutismKB 2.0

Annotation Detail for ADCY2


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Basic Information Top
Gene Symbol:ADCY2 ( AC2,FLJ16822,FLJ45092,HBAC2,KIAA1060,MGC133314 )
Gene Full Name: adenylate cyclase 2 (brain)
Band: 5p15.31
Quick LinksEntrez ID:108; OMIM: 103071; Uniprot ID:ADCY2_HUMAN; ENSEMBL ID: ENSG00000078295; HGNC ID: 233
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus23 / 56401240
neonate0 / 310970 
infant2 / 2362084
juvenile2 / 5555635
adult53 / 193912127
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor12 / 26384545
glioma4 / 10688337
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia6 / 9725061
normal131 / 336030738
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain91 / 110098982
cervix0 / 481710 
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye1 / 2110544
heart4 / 8962644
intestine1 / 2344724
kidney1 / 2117774
larynx1 / 2414541
liver1 / 2077434
lung7 / 33697420
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth1 / 6705214
muscle6 / 10771555
nerve2 / 15768126
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta0 / 2808250 
prostate4 / 18934521
salivary gland0 / 201550 
skin3 / 21057414
spleen0 / 539520 
stomach1 / 9661910
testis20 / 33044260
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213217_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.3
Adipocyte4.5
AdrenalCortex4.7
Adrenalgland3.6
Amygdala196.85
Appendix5.85
AtrioventricularNode4.4
BDCA4+_DentriticCells4.15
Bonemarrow4.55
BronchialEpithelialCells5.1
CD105+_Endothelial4.1
CD14+_Monocytes4.6
CD19+_BCells(neg._sel.)4.2
CD33+_Myeloid5.95
CD34+5.2
CD4+_Tcells5.75
CD56+_NKCells4.8
CD71+_EarlyErythroid3.95
CD8+_Tcells4.2
CardiacMyocytes6.45
Caudatenucleus78.55
Cerebellum52.85
CerebellumPeduncles25.95
CiliaryGanglion2.95
CingulateCortex82.05
Colorectaladenocarcinoma4.95
DorsalRootGanglion5.75
FetalThyroid4.5
Fetalbrain48.75
Fetalliver3.7
Fetallung3.5
GlobusPallidus41.2
Heart6.4
Hypothalamus114.95
Kidney3.5
Leukemia_chronicMyelogenousK-5623.65
Leukemia_promyelocytic-HL-603.9
Leukemialymphoblastic(MOLT-4)3.9
Liver6.65
Lung5.75
Lymphnode5.1
Lymphoma_burkitts(Daudi)6.45
Lymphoma_burkitts(Raji)7.1
MedullaOblongata56.45
OccipitalLobe80.7
OlfactoryBulb36.45
Ovary3.1
Pancreas4.25
PancreaticIslet5.65
ParietalLobe65.05
Pituitary15.75
Placenta5.35
Pons50.85
PrefrontalCortex289.3
Prostate31.1
Salivarygland3.8
SkeletalMuscle41.4
Skin3.85
SmoothMuscle5.25
Spinalcord205.75
SubthalamicNucleus45.85
SuperiorCervicalGanglion10.7
TemporalLobe74.1
Testis7.75
TestisGermCell11.95
TestisIntersitial5.1
TestisLeydigCell5.35
TestisSeminiferousTubule8.1
Thalamus46.2
Thymus3.4
Thyroid9.15
Tongue10.05
Tonsil4.15
Trachea5.8
TrigeminalGanglion11.8
Uterus8.15
UterusCorpus10.35
WholeBlood4.6
Wholebrain214.05
colon11.3
pineal_day639.26
pineal_night469.2
retina90
small_intestine4.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P405973
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.27 ± 0.65
Basal Forebrain4.8 ± 1.01
Basal Part of Pons4.32 ± 0.65
Cerebellar Cortex4.05 ± 0.6
Cerebellar Nuclei4.27 ± 0.54
Claustrum6.24 ± 0.53
Epithalamus3.76 ± 0.99
Frontal Lobe5.34 ± 0.64
Globus Pallidus3.21 ± 1.41
Hypothalamus4.09 ± 0.52
Insula5.51 ± 0.4
Limbic Lobe5.36 ± 0.87
Mesencephalon4.62 ± 0.8
Myelencephalon4.7 ± 0.84
Occipital Lobe4.01 ± 1.02
Parietal Lobe4.83 ± 0.81
Pontine Tegmentum4.73 ± 0.89
Striatum2.97 ± 1.69
Subthalamus4.49 ± 0.83
Temporal Lobe5.18 ± 0.57
Thalamus4.02 ± 0.88
White Matter2.97 ± 1.91
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Adcy2CBCerebellum17.28
23.31
Adcy2CTXCerebral cortex100
100
Adcy2HIPHippocampal region100
100
Adcy2HPFHippocampal formation100
100
Adcy2HYHypothalamus62.28
66.8
Adcy2LSXLateral septal complex73.93
92
Adcy2MBMidbrain63.47
78.84
Adcy2MYMedulla40.75
57.05
Adcy2OLFOlfactory bulb100
100
Adcy2PPons24.1
30.71
Adcy2PALPallidum59.67
84.87
Adcy2RHPRetrohippocampal region100
100
Adcy2sAMYStriatum-like amygdalar nuclei74.27
82.79
Adcy2STRStriatum31.59
42.12
Adcy2STRdStriatum dorsal region21.3
31.17
Adcy2STRvStriatum ventral region33.81
44.44
Adcy2THThalamus29.64
41.7
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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