AutismKB 2.0

Annotation Detail for ADAM28


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Basic Information Top
Gene Symbol:ADAM28 ( ADAM 28,ADAM23,MDC-L,MDC-Lm,MDC-Ls,MDCL,eMDC II,eMDCII )
Gene Full Name: ADAM metallopeptidase domain 28
Band: 8p21.2
Quick LinksEntrez ID:10863; OMIM: 606188; Uniprot ID:ADA28_HUMAN; ENSEMBL ID: ENSG00000042980; HGNC ID: 206
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus2 / 5640123
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult27 / 193912113
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor2 / 2638457
glioma0 / 1068830 
head and neck tumor5 / 13630236
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma2 / 7175527
non-neoplasia1 / 9725010
normal29 / 33603078
ovarian tumor9 / 76682117
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain6 / 11009895
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine3 / 23447212
kidney3 / 21177714
larynx2 / 2414582
liver0 / 2077430 
lung4 / 33697411
lymph2 / 4427045
lymph node5 / 9161054
mammary gland2 / 15327113
mouth1 / 6705214
muscle1 / 1077159
nerve0 / 157680 
ovary9 / 10205188
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen2 / 5395237
stomach1 / 9661910
testis3 / 3304429
thymus2 / 8113124
thyroid2 / 4747342
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208269_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.9
Adipocyte7.65
AdrenalCortex9.2
Adrenalgland6.7
Amygdala6.8
Appendix8.7
AtrioventricularNode32.2
BDCA4+_DentriticCells8.75
Bonemarrow12.65
BronchialEpithelialCells7.65
CD105+_Endothelial8.45
CD14+_Monocytes8.25
CD19+_BCells(neg._sel.)32.9
CD33+_Myeloid9.65
CD34+11.15
CD4+_Tcells7.2
CD56+_NKCells9.05
CD71+_EarlyErythroid7.1
CD8+_Tcells6.2
CardiacMyocytes17.55
Caudatenucleus6.95
Cerebellum6.4
CerebellumPeduncles8.8
CiliaryGanglion6.4
CingulateCortex8.25
Colorectaladenocarcinoma7.75
DorsalRootGanglion6.65
FetalThyroid9.1
Fetalbrain8
Fetalliver7.05
Fetallung5.7
GlobusPallidus8.5
Heart9.7
Hypothalamus8.1
Kidney10.2
Leukemia_chronicMyelogenousK-5627.65
Leukemia_promyelocytic-HL-609.1
Leukemialymphoblastic(MOLT-4)6.25
Liver10.05
Lung8.3
Lymphnode6.75
Lymphoma_burkitts(Daudi)11.4
Lymphoma_burkitts(Raji)11.1
MedullaOblongata7.1
OccipitalLobe6.9
OlfactoryBulb5.8
Ovary5.55
Pancreas6.2
PancreaticIslet8.35
ParietalLobe8.25
Pituitary28.05
Placenta8.05
Pons7.35
PrefrontalCortex7.85
Prostate8.95
Salivarygland9.6
SkeletalMuscle10.35
Skin6.6
SmoothMuscle8.1
Spinalcord9.55
SubthalamicNucleus7.5
SuperiorCervicalGanglion12.75
TemporalLobe7.7
Testis6.65
TestisGermCell6.35
TestisIntersitial6.25
TestisLeydigCell15.3
TestisSeminiferousTubule6.7
Thalamus7.95
Thymus5.35
Thyroid8.1
Tongue8.65
Tonsil15.3
Trachea7.1
TrigeminalGanglion8.1
Uterus5.65
UterusCorpus7.15
WholeBlood8.2
Wholebrain5.6
colon7.65
pineal_day8.84
pineal_night8.46
retina9.975
small_intestine7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9842_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.03 ± 0.87
Basal Forebrain3.82 ± 0.73
Basal Part of Pons4.9 ± 0.45
Cerebellar Cortex3.24 ± 0.55
Cerebellar Nuclei5.41 ± 0.5
Claustrum4.01 ± 1.04
Epithalamus4.79 ± 0.72
Frontal Lobe3.8 ± 0.79
Globus Pallidus5.63 ± 0.44
Hypothalamus3.72 ± 1.27
Insula3.97 ± 0.54
Limbic Lobe3.77 ± 0.77
Mesencephalon3.95 ± 0.81
Myelencephalon3.9 ± 0.81
Occipital Lobe3.58 ± 0.78
Parietal Lobe3.89 ± 0.82
Pontine Tegmentum3.73 ± 0.76
Striatum4.6 ± 0.57
Subthalamus4.58 ± 0.35
Temporal Lobe3.96 ± 0.76
Thalamus3.91 ± 0.69
White Matter5.88 ± 0.61
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Adam28CBCerebellum0.55
0.83
Adam28CTXCerebral cortex1.48
1.58
Adam28HIPHippocampal region0.64
0.91
Adam28HPFHippocampal formation0.62
0.75
Adam28HYHypothalamus1.39
1.3
Adam28LSXLateral septal complex0.44
0.27
Adam28MBMidbrain1.08
1.33
Adam28MYMedulla1.52
1.76
Adam28OLFOlfactory bulb1.36
1.01
Adam28PPons1.54
1.88
Adam28PALPallidum0.6
0.57
Adam28RHPRetrohippocampal region0.5
0.41
Adam28sAMYStriatum-like amygdalar nuclei0.47
0.46
Adam28STRStriatum0.28
0.24
Adam28STRdStriatum dorsal region0.11
0.11
Adam28STRvStriatum ventral region0.62
0.52
Adam28THThalamus1.14
0.98
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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