AutismKB 2.0

Annotation Detail for ME3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ME3 ( FLJ34862 )
Gene Full Name: malic enzyme 3, NADP(+)-dependent, mitochondrial
Band: 11q14.2
Quick LinksEntrez ID:10873; OMIM: 604626; Uniprot ID:MAON_HUMAN; ENSEMBL ID: ENSG00000151376; HGNC ID: 6985
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus23 / 56401240
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult75 / 193912138
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor1 / 3436629
chondrosarcoma0 / 828230 
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor10 / 26384537
glioma5 / 10688346
head and neck tumor0 / 1363020 
kidney tumor6 / 6895987
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal146 / 336030743
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer1 / 1026809
retinoblastoma1 / 4635621
skin tumor1 / 1249498
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland3 / 3319790
ascites1 / 4001524
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain49 / 110098944
cervix1 / 4817120
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye11 / 21105452
heart4 / 8962644
intestine8 / 23447234
kidney17 / 21177780
larynx0 / 241450 
liver4 / 20774319
lung16 / 33697447
lymph0 / 442700 
lymph node0 / 916100 
mammary gland8 / 15327152
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary1 / 1020519
pancreas11 / 21481251
parathyroid5 / 20539243
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta7 / 28082524
prostate5 / 18934526
salivary gland0 / 201550 
skin3 / 21057414
spleen1 / 5395218
stomach3 / 9661931
testis10 / 33044230
thymus1 / 8113112
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204663_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.8
Adipocyte11.15
AdrenalCortex16.4
Adrenalgland9.6
Amygdala33.75
Appendix12
AtrioventricularNode8.35
BDCA4+_DentriticCells7.65
Bonemarrow10.95
BronchialEpithelialCells9.5
CD105+_Endothelial15.55
CD14+_Monocytes10.85
CD19+_BCells(neg._sel.)9.35
CD33+_Myeloid13.05
CD34+74.55
CD4+_Tcells11.05
CD56+_NKCells12.15
CD71+_EarlyErythroid10.35
CD8+_Tcells5.55
CardiacMyocytes14.4
Caudatenucleus54
Cerebellum9.6
CerebellumPeduncles12.8
CiliaryGanglion7.9
CingulateCortex15.75
Colorectaladenocarcinoma12.85
DorsalRootGanglion8.75
FetalThyroid11.1
Fetalbrain21
Fetalliver8.8
Fetallung12.3
GlobusPallidus11.7
Heart54.7
Hypothalamus22.1
Kidney9.05
Leukemia_chronicMyelogenousK-56210.2
Leukemia_promyelocytic-HL-608.8
Leukemialymphoblastic(MOLT-4)8.65
Liver13.4
Lung12.55
Lymphnode9.9
Lymphoma_burkitts(Daudi)13.25
Lymphoma_burkitts(Raji)15.2
MedullaOblongata17.6
OccipitalLobe18.35
OlfactoryBulb9
Ovary7.45
Pancreas10.8
PancreaticIslet21.25
ParietalLobe14
Pituitary29.3
Placenta10.2
Pons17.8
PrefrontalCortex25.3
Prostate13.5
Salivarygland9.05
SkeletalMuscle13.45
Skin8.55
SmoothMuscle11
Spinalcord12.1
SubthalamicNucleus20.45
SuperiorCervicalGanglion12.6
TemporalLobe12.65
Testis12
TestisGermCell25.35
TestisIntersitial9.65
TestisLeydigCell10.65
TestisSeminiferousTubule10.9
Thalamus35.65
Thymus8.95
Thyroid14.3
Tongue11.05
Tonsil11
Trachea9.4
TrigeminalGanglion10.9
Uterus9.8
UterusCorpus16.75
WholeBlood8.6
Wholebrain24.05
colon11.75
pineal_day25.52
pineal_night39.2
retina13.7
small_intestine10.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P105227
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.46 ± 0.42
Basal Forebrain6.08 ± 0.52
Basal Part of Pons6.84 ± 0.25
Cerebellar Cortex6.17 ± 0.23
Cerebellar Nuclei5.96 ± 0.47
Claustrum6.58 ± 0.37
Epithalamus5.47 ± 0.65
Frontal Lobe6.12 ± 0.31
Globus Pallidus5.78 ± 0.2
Hypothalamus5.89 ± 0.28
Insula6.36 ± 0.29
Limbic Lobe6.52 ± 0.4
Mesencephalon6.18 ± 0.46
Myelencephalon6.25 ± 0.47
Occipital Lobe6.73 ± 0.61
Parietal Lobe6.29 ± 0.34
Pontine Tegmentum6.15 ± 0.4
Striatum7.28 ± 0.45
Subthalamus6.11 ± 0.13
Temporal Lobe6.25 ± 0.27
Thalamus6.37 ± 0.4
White Matter4.63 ± 0.13
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Me3CBCerebellum11.38
13.82
Me3CTXCerebral cortex22.28
14.02
Me3HIPHippocampal region14.72
12.55
Me3HPFHippocampal formation15.37
12.03
Me3HYHypothalamus2.97
2.33
Me3LSXLateral septal complex2.02
1.17
Me3MBMidbrain3.55
3.41
Me3MYMedulla8.02
7.9
Me3OLFOlfactory bulb30.28
20.2
Me3PPons4.75
4.5
Me3PALPallidum6.16
4.72
Me3RHPRetrohippocampal region16
10.95
Me3sAMYStriatum-like amygdalar nuclei13.25
8.42
Me3STRStriatum11.3
6.98
Me3STRdStriatum dorsal region12.52
7.89
Me3STRvStriatum ventral region8.72
4.85
Me3THThalamus4.84
4
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00010481 18 191 208 ILGLGDLGCYGMGIPVGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved