AutismKB 2.0

Annotation Detail for ADCY3


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Basic Information Top
Gene Symbol:ADCY3 ( AC3,KIAA0511 )
Gene Full Name: adenylate cyclase 3
Band: 2p23.3
Quick LinksEntrez ID:109; OMIM: 600291; Uniprot ID:ADCY3_HUMAN; ENSEMBL ID: ENSG00000138031; HGNC ID: 234
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst1 / 6231916
fetus9 / 56401215
neonate1 / 3109732
infant1 / 2362042
juvenile2 / 5555635
adult68 / 193912135
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor3 / 3436687
chondrosarcoma6 / 8282372
colorectal tumor4 / 11424635
esophageal tumor1 / 1729057
gastrointestinal tumor12 / 119369100
germ cell tumor6 / 26384522
glioma11 / 106883102
head and neck tumor2 / 13630214
kidney tumor3 / 6895943
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma2 / 7175527
non-neoplasia5 / 9725051
normal106 / 336030731
ovarian tumor9 / 76682117
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer2 / 10268019
retinoblastoma1 / 4635621
skin tumor3 / 12494924
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites3 / 4001574
bladder0 / 297570 
blood1 / 1234788
bone4 / 7165555
bone marrow2 / 4880140
brain42 / 110098938
cervix4 / 4817183
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus1 / 2020949
eye3 / 21105414
heart1 / 8962611
intestine15 / 23447263
kidney6 / 21177728
larynx1 / 2414541
liver2 / 2077439
lung5 / 33697414
lymph1 / 4427022
lymph node6 / 9161065
mammary gland4 / 15327126
mouth1 / 6705214
muscle4 / 10771537
nerve1 / 1576863
ovary9 / 10205188
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta17 / 28082560
prostate2 / 18934510
salivary gland0 / 201550 
skin5 / 21057423
spleen1 / 5395218
stomach8 / 9661982
testis9 / 33044227
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord0 / 136800 
uterus12 / 23287851
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209321_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts43.05
Adipocyte32.45
AdrenalCortex19
Adrenalgland10.35
Amygdala24.95
Appendix22.05
AtrioventricularNode26.45
BDCA4+_DentriticCells25.45
Bonemarrow16.55
BronchialEpithelialCells13.95
CD105+_Endothelial14.6
CD14+_Monocytes10.1
CD19+_BCells(neg._sel.)13
CD33+_Myeloid18
CD34+23
CD4+_Tcells15
CD56+_NKCells12.85
CD71+_EarlyErythroid10.75
CD8+_Tcells10.9
CardiacMyocytes30.65
Caudatenucleus48.8
Cerebellum15.05
CerebellumPeduncles32.2
CiliaryGanglion13.8
CingulateCortex15.75
Colorectaladenocarcinoma57.05
DorsalRootGanglion17.65
FetalThyroid15.7
Fetalbrain22.5
Fetalliver13.4
Fetallung18.55
GlobusPallidus15.9
Heart23.05
Hypothalamus21.6
Kidney8.75
Leukemia_chronicMyelogenousK-56217.95
Leukemia_promyelocytic-HL-6033.35
Leukemialymphoblastic(MOLT-4)17.05
Liver21
Lung29.75
Lymphnode14.65
Lymphoma_burkitts(Daudi)16.85
Lymphoma_burkitts(Raji)25.75
MedullaOblongata19.15
OccipitalLobe15.7
OlfactoryBulb19.4
Ovary17.75
Pancreas12.25
PancreaticIslet16.1
ParietalLobe21.65
Pituitary26.45
Placenta132.65
Pons18.5
PrefrontalCortex30.15
Prostate9.85
Salivarygland11.25
SkeletalMuscle22.6
Skin13.9
SmoothMuscle12.35
Spinalcord19
SubthalamicNucleus12.9
SuperiorCervicalGanglion35.1
TemporalLobe15.75
Testis12.7
TestisGermCell10.55
TestisIntersitial16.45
TestisLeydigCell17
TestisSeminiferousTubule15.5
Thalamus19.9
Thymus11
Thyroid12.65
Tongue16.85
Tonsil13.45
Trachea12.2
TrigeminalGanglion28.25
Uterus29.85
UterusCorpus36.5
WholeBlood12.4
Wholebrain33.55
colon12.4
pineal_day14.56
pineal_night12.8
retina29.525
small_intestine25.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10952_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.66 ± 0.47
Basal Forebrain4.3 ± 0.56
Basal Part of Pons4.58 ± 0.54
Cerebellar Cortex4.46 ± 0.29
Cerebellar Nuclei4.15 ± 0.43
Claustrum4.84 ± 0.62
Epithalamus3.72 ± 0.78
Frontal Lobe4.44 ± 0.57
Globus Pallidus4.07 ± 0.54
Hypothalamus4.34 ± 0.5
Insula4.41 ± 0.49
Limbic Lobe4.62 ± 0.44
Mesencephalon4.49 ± 0.63
Myelencephalon4.6 ± 0.6
Occipital Lobe4.82 ± 0.43
Parietal Lobe4.56 ± 0.51
Pontine Tegmentum4.59 ± 0.64
Striatum5.8 ± 0.4
Subthalamus3.73 ± 0.81
Temporal Lobe4.51 ± 0.52
Thalamus4.81 ± 0.44
White Matter4.59 ± 0.28
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Adcy3CBCerebellum4.76
4.51
Adcy3CTXCerebral cortex14.25
9.11
Adcy3HIPHippocampal region39.86
25.16
Adcy3HPFHippocampal formation36.61
23.72
Adcy3HYHypothalamus17.52
10.74
Adcy3LSXLateral septal complex2.56
1.47
Adcy3MBMidbrain11.14
8
Adcy3MYMedulla19.25
15.63
Adcy3OLFOlfactory bulb19.94
11.77
Adcy3PPons16.19
12.62
Adcy3PALPallidum13.85
9.42
Adcy3RHPRetrohippocampal region32.46
21.59
Adcy3sAMYStriatum-like amygdalar nuclei17.22
11.05
Adcy3STRStriatum13.88
7.73
Adcy3STRdStriatum dorsal region13.44
7.43
Adcy3STRvStriatum ventral region19.88
9.92
Adcy3THThalamus5.47
3.34
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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