AutismKB 2.0

Annotation Detail for PRSS21


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Basic Information Top
Gene Symbol:PRSS21 ( ESP-1,ESP1,TEST1,TESTISIN )
Gene Full Name: protease, serine, 21 (testisin)
Band: 16p13.3
Quick LinksEntrez ID:10942; OMIM: 608159; Uniprot ID:TEST_HUMAN; ENSEMBL ID: ENSG00000007038; HGNC ID: 9485
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus1 / 5640121
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult18 / 19391219
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor6 / 34366174
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor1 / 2638453
glioma5 / 10688346
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal19 / 33603075
ovarian tumor3 / 7668239
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain7 / 11009896
cervix8 / 48171166
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine1 / 2344724
kidney0 / 2117770 
larynx1 / 2414541
liver2 / 2077439
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary3 / 10205129
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis23 / 33044269
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 220051_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.65
Adipocyte4.65
AdrenalCortex4.35
Adrenalgland4.05
Amygdala4.85
Appendix4.9
AtrioventricularNode3.65
BDCA4+_DentriticCells4.95
Bonemarrow8.05
BronchialEpithelialCells4.6
CD105+_Endothelial4.7
CD14+_Monocytes4.95
CD19+_BCells(neg._sel.)6.45
CD33+_Myeloid5.9
CD34+5.95
CD4+_Tcells6.2
CD56+_NKCells6.45
CD71+_EarlyErythroid4.45
CD8+_Tcells4.4
CardiacMyocytes6.5
Caudatenucleus4.2
Cerebellum3.85
CerebellumPeduncles5.35
CiliaryGanglion3.1
CingulateCortex4.85
Colorectaladenocarcinoma4.8
DorsalRootGanglion3.55
FetalThyroid4.6
Fetalbrain4.35
Fetalliver4.15
Fetallung3.75
GlobusPallidus3.45
Heart6.4
Hypothalamus5.2
Kidney3.95
Leukemia_chronicMyelogenousK-56276.25
Leukemia_promyelocytic-HL-603.85
Leukemialymphoblastic(MOLT-4)3.75
Liver6.45
Lung31.65
Lymphnode3.95
Lymphoma_burkitts(Daudi)6.15
Lymphoma_burkitts(Raji)6.75
MedullaOblongata4.25
OccipitalLobe4.2
OlfactoryBulb3.55
Ovary3.2
Pancreas3.8
PancreaticIslet5.1
ParietalLobe5.1
Pituitary5.55
Placenta4.85
Pons5
PrefrontalCortex5.5
Prostate6.3
Salivarygland5.9
SkeletalMuscle19.75
Skin3.75
SmoothMuscle5.3
Spinalcord5.15
SubthalamicNucleus4.6
SuperiorCervicalGanglion5.9
TemporalLobe4.35
Testis237.45
TestisGermCell65.1
TestisIntersitial70.85
TestisLeydigCell79.6
TestisSeminiferousTubule86
Thalamus4.85
Thymus3.65
Thyroid5.8
Tongue4.8
Tonsil4.6
Trachea4.85
TrigeminalGanglion4.9
Uterus3.8
UterusCorpus4.35
WholeBlood5.1
Wholebrain3.9
colon5.1
pineal_day8.9
pineal_night5.62
retina5.7
small_intestine4.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_4879_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.22 ± 0.81
Basal Forebrain3.04 ± 1
Basal Part of Pons2.75 ± 0.61
Cerebellar Cortex2.96 ± 0.69
Cerebellar Nuclei2.99 ± 0.81
Claustrum3.75 ± 0.87
Epithalamus2.46 ± 0.52
Frontal Lobe2.67 ± 0.67
Globus Pallidus3.27 ± 0.59
Hypothalamus2.57 ± 0.58
Insula2.84 ± 0.69
Limbic Lobe2.97 ± 0.66
Mesencephalon2.82 ± 0.71
Myelencephalon2.96 ± 0.74
Occipital Lobe3.03 ± 0.61
Parietal Lobe2.97 ± 0.89
Pontine Tegmentum2.91 ± 0.72
Striatum2.86 ± 0.65
Subthalamus2.47 ± 0.46
Temporal Lobe2.78 ± 0.71
Thalamus2.89 ± 0.7
White Matter4.09 ± 0.27
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Prss21CBCerebellum1.39
1.89
Prss21CTXCerebral cortex0.83
1.05
Prss21HIPHippocampal region0.76
1
Prss21HPFHippocampal formation0.66
0.82
Prss21HYHypothalamus0.26
0.24
Prss21LSXLateral septal complex0.47
0.84
Prss21MBMidbrain1.11
1.49
Prss21MYMedulla2.25
2.22
Prss21OLFOlfactory bulb2.44
3.96
Prss21PPons0.57
0.53
Prss21PALPallidum0.38
0.55
Prss21RHPRetrohippocampal region0.45
0.49
Prss21sAMYStriatum-like amygdalar nuclei1.95
2.07
Prss21STRStriatum0.71
0.85
Prss21STRdStriatum dorsal region0.45
0.55
Prss21STRvStriatum ventral region1.18
1.38
Prss21THThalamus0.96
1.08
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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