AutismKB 2.0

Annotation Detail for YWHAQ


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Basic Information Top
Gene Symbol:YWHAQ ( 14-3-3,1C5,HS1 )
Gene Full Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
Band: 2p25.1
Quick LinksEntrez ID:10971; OMIM: 609009; Uniprot ID:1433T_HUMAN; ENSEMBL ID: ENSG00000134308; HGNC ID: 12854
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body37 / 70761522
blastocyst28 / 62319449
fetus142 / 564012251
neonate9 / 31097289
infant2 / 2362084
juvenile16 / 55556287
adult501 / 1939121258
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor12 / 12794937
bladder carcinoma7 / 17475400
breast (mammary gland) tumor28 / 94178297
cervical tumor17 / 34366494
chondrosarcoma31 / 82823374
colorectal tumor28 / 114246245
esophageal tumor3 / 17290173
gastrointestinal tumor35 / 119369293
germ cell tumor103 / 263845390
glioma36 / 106883336
head and neck tumor39 / 136302286
kidney tumor23 / 68959333
leukemia35 / 95842365
liver tumor31 / 96359321
lung tumor27 / 103127261
lymphoma26 / 71755362
non-neoplasia12 / 97250123
normal778 / 3360307231
ovarian tumor21 / 76682273
pancreatic tumor59 / 104616563
primitive neuroectodermal tumor of the CNS48 / 125680381
prostate cancer44 / 102680428
retinoblastoma26 / 46356560
skin tumor45 / 124949360
soft tissue/muscle tissue tumor70 / 125191559
uterine tumor27 / 90257299
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland15 / 33197451
ascites6 / 40015149
bladder13 / 29757436
blood71 / 123478575
bone31 / 71655432
bone marrow20 / 48801409
brain315 / 1100989286
cervix17 / 48171352
connective tissue45 / 149255301
ear1 / 1621261
embryonic tissue110 / 215722509
esophagus3 / 20209148
eye65 / 211054307
heart16 / 89626178
intestine55 / 234472234
kidney43 / 211777203
larynx9 / 24145372
liver39 / 207743187
lung71 / 336974210
lymph12 / 44270271
lymph node54 / 91610589
mammary gland49 / 153271319
mouth9 / 67052134
muscle15 / 107715139
nerve3 / 15768190
ovary22 / 102051215
pancreas102 / 214812474
parathyroid3 / 20539146
pharynx4 / 4132896
pituitary gland6 / 16585361
placenta72 / 280825256
prostate58 / 189345306
salivary gland5 / 20155248
skin82 / 210574389
spleen0 / 539520 
stomach36 / 96619372
testis123 / 330442372
thymus4 / 8113149
thyroid20 / 47473421
tonsil2 / 16999117
trachea1 / 5241319
umbilical cord9 / 13680657
uterus77 / 232878330
vascular16 / 51780308
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200693_at
Cell line Expression level Expression bar
721_B_lymphoblasts1244.35
Adipocyte708.9
AdrenalCortex129.35
Adrenalgland281.45
Amygdala2185.1
Appendix194.4
AtrioventricularNode145.05
BDCA4+_DentriticCells592.9
Bonemarrow279.8
BronchialEpithelialCells1825.6
CD105+_Endothelial1181.2
CD14+_Monocytes423.8
CD19+_BCells(neg._sel.)1015.55
CD33+_Myeloid455.45
CD34+1291.75
CD4+_Tcells806.15
CD56+_NKCells1099.2
CD71+_EarlyErythroid968.05
CD8+_Tcells750.7
CardiacMyocytes1110.9
Caudatenucleus675.85
Cerebellum766.45
CerebellumPeduncles1198.85
CiliaryGanglion160.1
CingulateCortex484.25
Colorectaladenocarcinoma1359.75
DorsalRootGanglion271.75
FetalThyroid543.1
Fetalbrain1576.5
Fetalliver393.25
Fetallung688.5
GlobusPallidus410.85
Heart177.7
Hypothalamus1525.05
Kidney267.55
Leukemia_chronicMyelogenousK-562554.05
Leukemia_promyelocytic-HL-60668.45
Leukemialymphoblastic(MOLT-4)1106.1
Liver216.2
Lung746
Lymphnode294.25
Lymphoma_burkitts(Daudi)1094.25
Lymphoma_burkitts(Raji)599.5
MedullaOblongata694.65
OccipitalLobe1344.2
OlfactoryBulb406.4
Ovary206.4
Pancreas402.05
PancreaticIslet1002.9
ParietalLobe990.3
Pituitary718.3
Placenta465
Pons427.45
PrefrontalCortex865.85
Prostate1204.55
Salivarygland342.25
SkeletalMuscle9.25
Skin131.15
SmoothMuscle1475.85
Spinalcord723.4
SubthalamicNucleus478.15
SuperiorCervicalGanglion53.3
TemporalLobe371.95
Testis708.8
TestisGermCell930.75
TestisIntersitial846.35
TestisLeydigCell689.4
TestisSeminiferousTubule469.7
Thalamus1094
Thymus566.35
Thyroid1069.35
Tongue286.8
Tonsil441.75
Trachea321.9
TrigeminalGanglion109.5
Uterus855.25
UterusCorpus397.2
WholeBlood523.95
Wholebrain1343.8
colon799.35
pineal_day1324.46
pineal_night1761.5
retina989.2
small_intestine696.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P131723
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.94 ± 0.36
Basal Forebrain11.16 ± 0.25
Basal Part of Pons11.45 ± 0.28
Cerebellar Cortex11.51 ± 0.14
Cerebellar Nuclei11.59 ± 0.16
Claustrum10.97 ± 0.43
Epithalamus11.28 ± 0.32
Frontal Lobe11.35 ± 0.33
Globus Pallidus11.25 ± 0.21
Hypothalamus11.6 ± 0.14
Insula11.26 ± 0.23
Limbic Lobe10.99 ± 0.46
Mesencephalon11.14 ± 0.36
Myelencephalon11.17 ± 0.4
Occipital Lobe10.67 ± 0.43
Parietal Lobe11.11 ± 0.28
Pontine Tegmentum11.2 ± 0.36
Striatum10.53 ± 0.28
Subthalamus11.53 ± 0.42
Temporal Lobe11.28 ± 0.29
Thalamus11.25 ± 0.3
White Matter12.27 ± 0.36
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
YwhaqCBCerebellum52.65
90.28
YwhaqCTXCerebral cortex81.87
83.02
YwhaqHIPHippocampal region84.58
100
YwhaqHPFHippocampal formation84.74
100
YwhaqHYHypothalamus61.34
64.82
YwhaqLSXLateral septal complex72.49
71.59
YwhaqMBMidbrain59.27
70.92
YwhaqMYMedulla75.12
93.94
YwhaqOLFOlfactory bulb91.92
87.17
YwhaqPPons76.72
95.37
YwhaqPALPallidum59.93
78.63
YwhaqRHPRetrohippocampal region85.98
93.68
YwhaqsAMYStriatum-like amygdalar nuclei46.91
48.59
YwhaqSTRStriatum32.48
34.25
YwhaqSTRdStriatum dorsal region25.41
28.75
YwhaqSTRvStriatum ventral region35.46
32.17
YwhaqTHThalamus79.83
97.14
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
1433T_HUMAN_0 0 0 0 AVTEQGAELSNEER PRIDE
1433T_HUMAN_0 0 0 0 DSTLIMQLLR PRIDE
1433T_HUMAN_0 0 0 0 SICTTVLELLDK PRIDE
1433T_HUMAN_0 0 0 0 TAFDEAIAELDTLNEDSYK PRIDE
1433T_HUMAN_0 0 0 0 YLAEVACGDDRK PRIDE
1433T_HUMAN_1 18 1 18 MEKTELIQKAKLAEQAER PRIDE
1433T_HUMAN_103 12 103 114 YLIANATNPESK PRIDE
1433T_HUMAN_11 16 11 26 LAEQAERYDDMATCMK PRIDE
1433T_HUMAN_127 11 127 137 YLAEVACGDDR PRIDE
1433T_HUMAN_127 12 127 138 YLAEVACGDDRK PRIDE
1433T_HUMAN_138 20 138 157 KQTIDNSQGAYQEAFDISKK PRIDE
1433T_HUMAN_139 19 139 157 QTIDNSQGAYQEAFDISKK PRIDE
1433T_HUMAN_158 9 158 166 EMQPTHPIR PRIDE
1433T_HUMAN_159 9 159 167 EMQPTHPIR PRIDE
1433T_HUMAN_193 19 193 211 TAFDEAIAELDTLNEDSYK PRIDE
1433T_HUMAN_193 29 193 221 TAFDEAIAELDTLNEDSYKDSTLIMQLLR PRIDE
1433T_HUMAN_212 10 212 221 DSTLIMQLLR PRIDE
1433T_HUMAN_213 10 213 222 DSTLIMQLLR PRIDE
1433T_HUMAN_27 14 27 40 AVTEQGAELSNEER PRIDE
1433T_HUMAN_27 22 27 48 AVTEQGAELSNEERNLLSVAYK PRIDE
1433T_HUMAN_4 8 4 11 TELIQKAK PRIDE
1433T_HUMAN_41 14 41 54 NLLSVAYKNVVGGR PRIDE
1433T_HUMAN_41 8 41 48 NLLSVAYK PRIDE
1433T_HUMAN_42 8 42 49 NLLSVAYK PRIDE
1433T_HUMAN_43 13 43 55 LLSVAYKNVVGGR PRIDE
1433T_HUMAN_60 14 60 73 VISSIEQKTDTSDK PRIDE
1433T_HUMAN_60 8 60 67 VISSIEQK PRIDE
1433T_HUMAN_84 8 84 91 EKVESELR PRIDE
1433T_HUMAN_91 12 91 102 SICTTVLELLDK PRIDE
1433T_HUMAN_91 24 91 114 SICTTVLELLDKYLIANATNPESK PRIDE
1433T_HUMAN_92 12 92 103 SICTTVLELLDK PRIDE
PAp00000475 18 10 27 AKLAEQAERYDDMATCMK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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