AutismKB 2.0

Annotation Detail for MAPRE2


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Basic Information Top
Gene Symbol:MAPRE2 ( EB1,EB2,RP1 )
Gene Full Name: microtubule-associated protein, RP/EB family, member 2
Band: 18q12.1-q12.2
Quick LinksEntrez ID:10982; OMIM: 605789; Uniprot ID:MARE2_HUMAN; ENSEMBL ID: ENSG00000166974; HGNC ID: 6891
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst1 / 6231916
fetus149 / 564012264
neonate5 / 31097160
infant2 / 2362084
juvenile5 / 5555689
adult159 / 193912181
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor4 / 9417842
cervical tumor4 / 34366116
chondrosarcoma6 / 8282372
colorectal tumor5 / 11424643
esophageal tumor1 / 1729057
gastrointestinal tumor6 / 11936950
germ cell tumor28 / 263845106
glioma8 / 10688374
head and neck tumor18 / 136302132
kidney tumor14 / 68959203
leukemia6 / 9584262
liver tumor4 / 9635941
lung tumor4 / 10312738
lymphoma4 / 7175555
non-neoplasia9 / 9725092
normal759 / 3360307225
ovarian tumor1 / 7668213
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer1 / 1026809
retinoblastoma2 / 4635643
skin tumor7 / 12494956
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland6 / 33197180
ascites0 / 400150 
bladder2 / 2975767
blood10 / 12347880
bone4 / 7165555
bone marrow3 / 4880161
brain577 / 1100989524
cervix5 / 48171103
connective tissue12 / 14925580
ear0 / 162120 
embryonic tissue14 / 21572264
esophagus1 / 2020949
eye18 / 21105485
heart7 / 8962678
intestine11 / 23447246
kidney24 / 211777113
larynx1 / 2414541
liver10 / 20774348
lung21 / 33697462
lymph4 / 4427090
lymph node12 / 91610130
mammary gland13 / 15327184
mouth12 / 67052178
muscle3 / 10771527
nerve3 / 15768190
ovary1 / 1020519
pancreas24 / 214812111
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland5 / 16585301
placenta16 / 28082556
prostate3 / 18934515
salivary gland0 / 201550 
skin14 / 21057466
spleen12 / 53952222
stomach11 / 96619113
testis23 / 33044269
thymus38 / 81131468
thyroid8 / 47473168
tonsil1 / 1699958
trachea2 / 5241338
umbilical cord2 / 13680146
uterus6 / 23287825
vascular13 / 51780251
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213489_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.75
Adipocyte5
AdrenalCortex13
Adrenalgland5.7
Amygdala86.3
Appendix4.1
AtrioventricularNode3.8
BDCA4+_DentriticCells9.05
Bonemarrow5.25
BronchialEpithelialCells3.6
CD105+_Endothelial5.7
CD14+_Monocytes4.1
CD19+_BCells(neg._sel.)6.8
CD33+_Myeloid7.15
CD34+12.6
CD4+_Tcells8.1
CD56+_NKCells24.3
CD71+_EarlyErythroid5.05
CD8+_Tcells9.25
CardiacMyocytes6.9
Caudatenucleus34.65
Cerebellum69.05
CerebellumPeduncles172.05
CiliaryGanglion4.45
CingulateCortex114.5
Colorectaladenocarcinoma3.65
DorsalRootGanglion4.55
FetalThyroid4.4
Fetalbrain51.85
Fetalliver5.15
Fetallung4.4
GlobusPallidus67.9
Heart7.65
Hypothalamus145
Kidney3.65
Leukemia_chronicMyelogenousK-5623.5
Leukemia_promyelocytic-HL-604.55
Leukemialymphoblastic(MOLT-4)3.75
Liver7.1
Lung6.2
Lymphnode5.1
Lymphoma_burkitts(Daudi)7.2
Lymphoma_burkitts(Raji)7.55
MedullaOblongata131.2
OccipitalLobe168.8
OlfactoryBulb17.1
Ovary2.5
Pancreas3.05
PancreaticIslet7.45
ParietalLobe142.05
Pituitary6.9
Placenta5.85
Pons34.4
PrefrontalCortex145.95
Prostate6.5
Salivarygland3
SkeletalMuscle5.95
Skin4.15
SmoothMuscle5.8
Spinalcord25.5
SubthalamicNucleus70.3
SuperiorCervicalGanglion4.3
TemporalLobe48.85
Testis3.9
TestisGermCell3.8
TestisIntersitial4.55
TestisLeydigCell3.7
TestisSeminiferousTubule3.65
Thalamus85.65
Thymus10.65
Thyroid5.6
Tongue4.4
Tonsil5.2
Trachea4.75
TrigeminalGanglion5.95
Uterus4.35
UterusCorpus3.45
WholeBlood5.85
Wholebrain107.15
colon5.7
pineal_day242.5
pineal_night237.86
retina52.95
small_intestine7.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P193911
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.01 ± 0.31
Basal Forebrain7.68 ± 0.33
Basal Part of Pons8.03 ± 0.3
Cerebellar Cortex7.74 ± 0.28
Cerebellar Nuclei7.82 ± 0.28
Claustrum7.79 ± 0.42
Epithalamus7.25 ± 0.6
Frontal Lobe8 ± 0.34
Globus Pallidus7.73 ± 0.22
Hypothalamus7.73 ± 0.25
Insula8.08 ± 0.36
Limbic Lobe8.06 ± 0.39
Mesencephalon7.85 ± 0.4
Myelencephalon7.88 ± 0.4
Occipital Lobe7.86 ± 0.31
Parietal Lobe7.88 ± 0.4
Pontine Tegmentum8.02 ± 0.32
Striatum7.7 ± 0.35
Subthalamus7.85 ± 0.49
Temporal Lobe7.96 ± 0.32
Thalamus8.13 ± 0.24
White Matter9.19 ± 0.23
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mapre2CBCerebellum100
100
Mapre2CTXCerebral cortex100
100
Mapre2HIPHippocampal region97.74
100
Mapre2HPFHippocampal formation100
100
Mapre2HYHypothalamus100
100
Mapre2LSXLateral septal complex100
95.16
Mapre2MBMidbrain100
100
Mapre2MYMedulla100
100
Mapre2OLFOlfactory bulb100
100
Mapre2PPons100
100
Mapre2PALPallidum99.99
97.05
Mapre2RHPRetrohippocampal region100
100
Mapre2sAMYStriatum-like amygdalar nuclei100
100
Mapre2STRStriatum100
100
Mapre2STRdStriatum dorsal region100
100
Mapre2STRvStriatum ventral region100
100
Mapre2THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MARE2_HUMAN_127 11 127 137 MNVDKVIPVEK PRIDE
MARE2_HUMAN_143 12 143 154 FQDNLDFIQWFK PRIDE
MARE2_HUMAN_143 13 143 155 FQDNLDFIQWFKK PRIDE
MARE2_HUMAN_155 18 155 172 KFYDANYDGKEYDPVEAR PRIDE
MARE2_HUMAN_156 17 156 172 FYDANYDGKEYDPVEAR PRIDE
MARE2_HUMAN_2 29 2 30 PGPTQTLSPNGENNNDIIQDNNGTIIPFR PRIDE
MARE2_HUMAN_226 29 226 254 ASSSGSASKSDKDLETQVIQLNEQVHSLK PRIDE
MARE2_HUMAN_235 20 235 254 SDKDLETQVIQLNEQVHSLK PRIDE
MARE2_HUMAN_255 10 255 264 LALEGVEKER PRIDE
MARE2_HUMAN_273 19 273 291 EIELLCQEHGQENDDLVQR PRIDE
PAp00066207 19 274 292 EIELLCQEHGQENDDLVQR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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