AutismKB 2.0

Annotation Detail for METAP2


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Basic Information Top
Gene Symbol:METAP2 ( MAP2,MNPEP,p67,p67eIF2 )
Gene Full Name: methionyl aminopeptidase 2
Band: 12q22
Quick LinksEntrez ID:10988; OMIM: 601870; Uniprot ID:AMPM2_HUMAN; ENSEMBL ID: ENSG00000111142; HGNC ID: 16672
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body11 / 70761155
blastocyst7 / 62319112
fetus50 / 56401288
neonate5 / 31097160
infant9 / 23620381
juvenile12 / 55556215
adult198 / 1939121102
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma1 / 1747557
breast (mammary gland) tumor8 / 9417884
cervical tumor3 / 3436687
chondrosarcoma14 / 82823169
colorectal tumor13 / 114246113
esophageal tumor6 / 17290347
gastrointestinal tumor14 / 119369117
germ cell tumor36 / 263845136
glioma6 / 10688356
head and neck tumor6 / 13630244
kidney tumor1 / 6895914
leukemia12 / 95842125
liver tumor20 / 96359207
lung tumor5 / 10312748
lymphoma15 / 71755209
non-neoplasia14 / 97250143
normal307 / 336030791
ovarian tumor4 / 7668252
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS26 / 125680206
prostate cancer17 / 102680165
retinoblastoma6 / 46356129
skin tumor5 / 12494940
soft tissue/muscle tissue tumor12 / 12519195
uterine tumor13 / 90257144
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland3 / 3319790
ascites3 / 4001574
bladder3 / 29757100
blood11 / 12347889
bone11 / 71655153
bone marrow8 / 48801163
brain70 / 110098963
cervix4 / 4817183
connective tissue23 / 149255154
ear6 / 16212370
embryonic tissue35 / 215722162
esophagus6 / 20209296
eye15 / 21105471
heart12 / 89626133
intestine25 / 234472106
kidney16 / 21177775
larynx2 / 2414582
liver36 / 207743173
lung24 / 33697471
lymph4 / 4427090
lymph node13 / 91610141
mammary gland16 / 153271104
mouth2 / 6705229
muscle9 / 10771583
nerve0 / 157680 
ovary4 / 10205139
pancreas5 / 21481223
parathyroid1 / 2053948
pharynx3 / 4132872
pituitary gland3 / 16585180
placenta26 / 28082592
prostate24 / 189345126
salivary gland0 / 201550 
skin13 / 21057461
spleen2 / 5395237
stomach9 / 9661993
testis42 / 330442127
thymus6 / 8113173
thyroid5 / 47473105
tonsil1 / 1699958
trachea4 / 5241376
umbilical cord5 / 13680365
uterus26 / 232878111
vascular14 / 51780270
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209861_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts474
Adipocyte70.8
AdrenalCortex36.45
Adrenalgland29.75
Amygdala61.95
Appendix38.4
AtrioventricularNode33.15
BDCA4+_DentriticCells129.1
Bonemarrow34
BronchialEpithelialCells179
CD105+_Endothelial772.15
CD14+_Monocytes87.4
CD19+_BCells(neg._sel.)76.05
CD33+_Myeloid135.55
CD34+215.5
CD4+_Tcells196.1
CD56+_NKCells104.6
CD71+_EarlyErythroid675.35
CD8+_Tcells111
CardiacMyocytes89.95
Caudatenucleus32.05
Cerebellum25.85
CerebellumPeduncles34.65
CiliaryGanglion25.85
CingulateCortex32.8
Colorectaladenocarcinoma60.15
DorsalRootGanglion27.25
FetalThyroid36.5
Fetalbrain59.3
Fetalliver154.1
Fetallung51.35
GlobusPallidus26.25
Heart35.2
Hypothalamus49.95
Kidney27.1
Leukemia_chronicMyelogenousK-562208.45
Leukemia_promyelocytic-HL-60344.05
Leukemialymphoblastic(MOLT-4)105.55
Liver26.7
Lung19.25
Lymphnode31.3
Lymphoma_burkitts(Daudi)358.3
Lymphoma_burkitts(Raji)94.8
MedullaOblongata32.55
OccipitalLobe57.3
OlfactoryBulb50.45
Ovary29.65
Pancreas60.55
PancreaticIslet79.45
ParietalLobe42.75
Pituitary96
Placenta32.55
Pons32.65
PrefrontalCortex89.25
Prostate37.5
Salivarygland44.3
SkeletalMuscle44.25
Skin34.75
SmoothMuscle189.95
Spinalcord51.15
SubthalamicNucleus53.9
SuperiorCervicalGanglion40.85
TemporalLobe30.9
Testis27.65
TestisGermCell113.25
TestisIntersitial90
TestisLeydigCell82.95
TestisSeminiferousTubule61.6
Thalamus48.3
Thymus21.8
Thyroid120.65
Tongue41.75
Tonsil143.05
Trachea30.55
TrigeminalGanglion37.75
Uterus91.25
UterusCorpus31
WholeBlood62.9
Wholebrain21.4
colon93.25
pineal_day143.4
pineal_night146.44
retina62.425
small_intestine45.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P141736
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.92 ± 0.71
Basal Forebrain3.52 ± 0.52
Basal Part of Pons3.82 ± 0.6
Cerebellar Cortex4.33 ± 0.28
Cerebellar Nuclei3.8 ± 0.67
Claustrum3.4 ± 0.75
Epithalamus3.99 ± 0.33
Frontal Lobe3.94 ± 0.53
Globus Pallidus3.37 ± 0.48
Hypothalamus4.35 ± 0.86
Insula4.04 ± 0.76
Limbic Lobe3.57 ± 0.63
Mesencephalon3.9 ± 0.61
Myelencephalon3.78 ± 0.61
Occipital Lobe3.51 ± 0.68
Parietal Lobe3.81 ± 0.66
Pontine Tegmentum3.77 ± 0.58
Striatum3.4 ± 0.62
Subthalamus3.86 ± 0.6
Temporal Lobe3.81 ± 0.5
Thalamus3.64 ± 0.57
White Matter2.98 ± 0.39
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Metap2CBCerebellum100
100
Metap2CTXCerebral cortex100
100
Metap2HIPHippocampal region100
100
Metap2HPFHippocampal formation100
100
Metap2HYHypothalamus69.84
94.74
Metap2LSXLateral septal complex84.41
86.83
Metap2MBMidbrain63.27
85.82
Metap2MYMedulla55.07
100
Metap2OLFOlfactory bulb100
100
Metap2PPons56.94
93.06
Metap2PALPallidum69.23
91.58
Metap2RHPRetrohippocampal region100
100
Metap2sAMYStriatum-like amygdalar nuclei100
100
Metap2STRStriatum90.94
100
Metap2STRdStriatum dorsal region81.56
86.9
Metap2STRvStriatum ventral region97.33
100
Metap2THThalamus71.37
86.87
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
AMPM2_HUMAN_44 25 44 68 SKGPSAAGEQEPDKESGASVDEVAR PRIDE
AMPM2_HUMAN_46 23 46 68 GPSAAGEQEPDKESGASVDEVAR PRIDE
AMPM2_HUMAN_73 25 73 97 SALEDKERDEDDEDGDGDGDGATGK PRIDE
PAp00003124 18 452 469 GSYTAQFEHTILLRPTCK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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