AutismKB 2.0

Annotation Detail for KIF2C


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Basic Information Top
Gene Symbol:KIF2C ( KNSL6,MCAK )
Gene Full Name: kinesin family member 2C
Band: 1p34.1
Quick LinksEntrez ID:11004; OMIM: 604538; Uniprot ID:KIF2C_HUMAN; ENSEMBL ID: ENSG00000142945; HGNC ID: 6393
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst12 / 62319192
fetus31 / 56401254
neonate7 / 31097225
infant1 / 2362042
juvenile11 / 55556197
adult123 / 193912163
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma8 / 8282396
colorectal tumor9 / 11424678
esophageal tumor4 / 17290231
gastrointestinal tumor14 / 119369117
germ cell tumor64 / 263845242
glioma7 / 10688365
head and neck tumor4 / 13630229
kidney tumor3 / 6895943
leukemia15 / 95842156
liver tumor16 / 96359166
lung tumor11 / 103127106
lymphoma12 / 71755167
non-neoplasia1 / 9725010
normal175 / 336030752
ovarian tumor4 / 7668252
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS22 / 125680175
prostate cancer1 / 1026809
retinoblastoma2 / 4635643
skin tumor1 / 1249498
soft tissue/muscle tissue tumor19 / 125191151
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites7 / 40015174
bladder2 / 2975767
blood6 / 12347848
bone6 / 7165583
bone marrow11 / 48801225
brain36 / 110098932
cervix6 / 48171124
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue25 / 215722115
esophagus4 / 20209197
eye2 / 2110549
heart1 / 8962611
intestine20 / 23447285
kidney9 / 21177742
larynx1 / 2414541
liver24 / 207743115
lung17 / 33697450
lymph11 / 44270248
lymph node6 / 9161065
mammary gland4 / 15327126
mouth4 / 6705259
muscle16 / 107715148
nerve0 / 157680 
ovary5 / 10205148
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta14 / 28082549
prostate1 / 1893455
salivary gland0 / 201550 
skin9 / 21057442
spleen0 / 539520 
stomach3 / 9661931
testis137 / 330442414
thymus23 / 81131283
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus8 / 23287834
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209408_at
Cell line Expression level Expression bar
721_B_lymphoblasts362.9
Adipocyte3.2
AdrenalCortex3.45
Adrenalgland2.7
Amygdala3.4
Appendix6.05
AtrioventricularNode2.45
BDCA4+_DentriticCells8.65
Bonemarrow10.8
BronchialEpithelialCells5.8
CD105+_Endothelial151.9
CD14+_Monocytes3.45
CD19+_BCells(neg._sel.)3.5
CD33+_Myeloid8.8
CD34+75.05
CD4+_Tcells3.5
CD56+_NKCells4.3
CD71+_EarlyErythroid164.85
CD8+_Tcells3.15
CardiacMyocytes49.05
Caudatenucleus2.85
Cerebellum2.6
CerebellumPeduncles3.65
CiliaryGanglion2.3
CingulateCortex3.35
Colorectaladenocarcinoma55.3
DorsalRootGanglion2.45
FetalThyroid3.15
Fetalbrain3.25
Fetalliver4.45
Fetallung2.95
GlobusPallidus2.35
Heart4.1
Hypothalamus3.55
Kidney2.6
Leukemia_chronicMyelogenousK-562176
Leukemia_promyelocytic-HL-6062
Leukemialymphoblastic(MOLT-4)229.05
Liver4.35
Lung3.6
Lymphnode2.8
Lymphoma_burkitts(Daudi)183.45
Lymphoma_burkitts(Raji)8.05
MedullaOblongata2.95
OccipitalLobe2.9
OlfactoryBulb2.6
Ovary2.1
Pancreas2.65
PancreaticIslet3.7
ParietalLobe3.35
Pituitary3.8
Placenta3.35
Pons3.05
PrefrontalCortex4
Prostate3.8
Salivarygland2.6
SkeletalMuscle3.75
Skin2.45
SmoothMuscle3.8
Spinalcord3.45
SubthalamicNucleus2.9
SuperiorCervicalGanglion3.75
TemporalLobe2.95
Testis106.4
TestisGermCell51.25
TestisIntersitial37
TestisLeydigCell12.1
TestisSeminiferousTubule19.65
Thalamus3.25
Thymus34.65
Thyroid4.1
Tongue3.15
Tonsil3.5
Trachea2.7
TrigeminalGanglion3.2
Uterus2.65
UterusCorpus3.3
WholeBlood3.55
Wholebrain2.75
colon3.3
pineal_day4.06
pineal_night3.96
retina3.9
small_intestine3.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12077_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.84 ± 0.98
Basal Forebrain2.15 ± 0.28
Basal Part of Pons1.96 ± 0.62
Cerebellar Cortex2.64 ± 0.67
Cerebellar Nuclei2.57 ± 0.71
Claustrum3.06 ± 0.89
Epithalamus2.15 ± 1.01
Frontal Lobe2.05 ± 0.7
Globus Pallidus2.76 ± 0.53
Hypothalamus2.31 ± 0.61
Insula2.32 ± 0.64
Limbic Lobe2.25 ± 0.68
Mesencephalon2.5 ± 0.82
Myelencephalon2.36 ± 0.73
Occipital Lobe2.53 ± 0.75
Parietal Lobe2.27 ± 0.87
Pontine Tegmentum2.3 ± 0.69
Striatum2.23 ± 0.71
Subthalamus2.36 ± 0.67
Temporal Lobe2.17 ± 0.71
Thalamus2.2 ± 0.72
White Matter2.75 ± 0.65
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Kif2cCBCerebellum0
0
Kif2cCTXCerebral cortex0
0
Kif2cHIPHippocampal region0
0
Kif2cHPFHippocampal formation0
0
Kif2cHYHypothalamus0
0
Kif2cLSXLateral septal complex0
0
Kif2cMBMidbrain0
0
Kif2cMYMedulla0
0
Kif2cOLFOlfactory bulb0
0
Kif2cPPons0
0
Kif2cPALPallidum0
0
Kif2cRHPRetrohippocampal region0
0
Kif2csAMYStriatum-like amygdalar nuclei0
0
Kif2cSTRStriatum0
0
Kif2cSTRdStriatum dorsal region0
0
Kif2cSTRvStriatum ventral region0
0
Kif2cTHThalamus0
0
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
KIF2C_HUMAN_2 9 2 10 AMDSSLQAR PRIDE
PAp00040073 23 55 77 EIDFDDVAAINPELLQLLPLHPK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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