AutismKB 2.0

Annotation Detail for TLK2


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Basic Information Top
Gene Symbol:TLK2 ( MGC44450,PKU-ALPHA )
Gene Full Name: tousled-like kinase 2
Band: 17q23
Quick LinksEntrez ID:11011; OMIM: 608439; Uniprot ID:TLK2_HUMAN; ENSEMBL ID: ENSG00000146872; HGNC ID: 11842
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst0 / 623190 
fetus51 / 56401290
neonate2 / 3109764
infant0 / 236200 
juvenile0 / 555560 
adult83 / 193912142
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor9 / 9417895
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor18 / 26384568
glioma2 / 10688318
head and neck tumor6 / 13630244
kidney tumor4 / 6895958
leukemia2 / 9584220
liver tumor1 / 9635910
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal165 / 336030749
ovarian tumor4 / 7668252
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer5 / 10268048
retinoblastoma4 / 4635686
skin tumor6 / 12494948
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites2 / 4001549
bladder0 / 297570 
blood5 / 12347840
bone4 / 7165555
bone marrow3 / 4880161
brain26 / 110098923
cervix0 / 481710 
connective tissue2 / 14925513
ear1 / 1621261
embryonic tissue19 / 21572288
esophagus0 / 202090 
eye10 / 21105447
heart1 / 8962611
intestine8 / 23447234
kidney10 / 21177747
larynx1 / 2414541
liver4 / 20774319
lung12 / 33697435
lymph0 / 442700 
lymph node3 / 9161032
mammary gland12 / 15327178
mouth3 / 6705244
muscle1 / 1077159
nerve1 / 1576863
ovary4 / 10205139
pancreas7 / 21481232
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta6 / 28082521
prostate5 / 18934526
salivary gland1 / 2015549
skin14 / 21057466
spleen1 / 5395218
stomach2 / 9661920
testis35 / 330442105
thymus3 / 8113136
thyroid2 / 4747342
tonsil2 / 16999117
trachea0 / 524130 
umbilical cord1 / 1368073
uterus12 / 23287851
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212986_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts46.05
Adipocyte13.35
AdrenalCortex13.75
Adrenalgland10.45
Amygdala14.5
Appendix14.6
AtrioventricularNode9.95
BDCA4+_DentriticCells23.15
Bonemarrow12.8
BronchialEpithelialCells13.5
CD105+_Endothelial13.3
CD14+_Monocytes14.55
CD19+_BCells(neg._sel.)38.7
CD33+_Myeloid26.45
CD34+20.9
CD4+_Tcells19.15
CD56+_NKCells22.85
CD71+_EarlyErythroid13.15
CD8+_Tcells20.2
CardiacMyocytes17.25
Caudatenucleus12.25
Cerebellum11.2
CerebellumPeduncles15.35
CiliaryGanglion9.25
CingulateCortex13.6
Colorectaladenocarcinoma13.55
DorsalRootGanglion10.1
FetalThyroid13.2
Fetalbrain13.85
Fetalliver11.65
Fetallung13.3
GlobusPallidus9.85
Heart17.05
Hypothalamus15.2
Kidney9.75
Leukemia_chronicMyelogenousK-56212.25
Leukemia_promyelocytic-HL-6011.95
Leukemialymphoblastic(MOLT-4)21.5
Liver17.75
Lung14.85
Lymphnode18.45
Lymphoma_burkitts(Daudi)27.2
Lymphoma_burkitts(Raji)19
MedullaOblongata12.55
OccipitalLobe12.45
OlfactoryBulb10.5
Ovary8.8
Pancreas10.8
PancreaticIslet14.4
ParietalLobe14.3
Pituitary19.65
Placenta14.05
Pons12.95
PrefrontalCortex16.75
Prostate15.85
Salivarygland10.9
SkeletalMuscle14.75
Skin10.1
SmoothMuscle15.8
Spinalcord14.1
SubthalamicNucleus12.55
SuperiorCervicalGanglion15.05
TemporalLobe12.35
Testis15.6
TestisGermCell28.55
TestisIntersitial40.6
TestisLeydigCell31.65
TestisSeminiferousTubule16.35
Thalamus13.65
Thymus12.5
Thyroid16.75
Tongue13
Tonsil13.6
Trachea11.4
TrigeminalGanglion13.75
Uterus11.5
UterusCorpus16.9
WholeBlood14.85
Wholebrain12.05
colon13.85
pineal_day17.32
pineal_night21.02
retina16.65
small_intestine12.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_3287_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.03 ± 0.25
Basal Forebrain9.11 ± 0.13
Basal Part of Pons8.83 ± 0.19
Cerebellar Cortex9.22 ± 0.13
Cerebellar Nuclei9.06 ± 0.28
Claustrum9.18 ± 0.31
Epithalamus9.27 ± 0.25
Frontal Lobe8.85 ± 0.26
Globus Pallidus9.3 ± 0.26
Hypothalamus8.79 ± 0.17
Insula8.86 ± 0.13
Limbic Lobe9.01 ± 0.32
Mesencephalon9 ± 0.28
Myelencephalon9 ± 0.26
Occipital Lobe9.28 ± 0.31
Parietal Lobe8.98 ± 0.23
Pontine Tegmentum8.96 ± 0.31
Striatum9.02 ± 0.3
Subthalamus8.86 ± 0.1
Temporal Lobe8.93 ± 0.21
Thalamus8.93 ± 0.2
White Matter10.06 ± 0.13
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tlk2CBCerebellum11.97
13.94
Tlk2CTXCerebral cortex22.03
15.73
Tlk2HIPHippocampal region19.82
18.89
Tlk2HPFHippocampal formation16.94
15.08
Tlk2HYHypothalamus3.92
3.51
Tlk2LSXLateral septal complex7.69
5.33
Tlk2MBMidbrain10.04
9.14
Tlk2MYMedulla16.53
17.68
Tlk2OLFOlfactory bulb17.29
12.78
Tlk2PPons8.43
9.44
Tlk2PALPallidum6.49
6.3
Tlk2RHPRetrohippocampal region11.99
9.78
Tlk2sAMYStriatum-like amygdalar nuclei3.3
2.32
Tlk2STRStriatum6.26
4.74
Tlk2STRdStriatum dorsal region6.35
5.04
Tlk2STRvStriatum ventral region6.99
4.44
Tlk2THThalamus11.82
10.13
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00071950 20 657 676 KPFGHNQSQQDILQENTILK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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